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Phenotypic Abnormality (PA): Abnormal digit morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of skeletal morphology [HP:0011842] <17>(86|89) (90|52|33)
+ + + 3:   Abnormality of the skeletal system [HP:0000924] <7>(88|98) (93|55|34)
+ + + 3:   Abnormality of limbs [HP:0040064] <8>(58|66) (63|33|25)
+ + 2:   Abnormality of limb bone [HP:0040068] <1>(29|32) (33|18|20)
+ + 2:   Abnormal appendicular skeleton morphology [HP:0011844] <4>(35|43) (39|23|23)
+ 1:   Abnormality of limb bone morphology [HP:0002813] <13>(29|32) (32|18|20)
0:   Abnormal digit morphology [HP:0011297] <10>(16|21) (18|14|16)
- 1:   Abnormality of toe [HP:0001780] <27>(6|7) (8|4|2)
- 1:   Abnormality of finger [HP:0001167] <24>(12|16) (13|9|10)
- 1:   Polydactyly [HP:0010442] <6>(2|2) (3|2|0)
- 1:   Broad phalanx [HP:0006009] <3>(0|0) (0|0|0)
- 1:   Short digit [HP:0011927] <3>(3|4) (4|4|4)
- 1:   Syndactyly [HP:0001159] <3>(1|2) (1|0|0)
- 1:   Clinodactyly [HP:0030084] <2>(0|3) (2|0|0)
- 1:   Clubbing [HP:0001217] <2>(0|1) (0|0|1)
- 1:   Macrodactyly [HP:0004099] <2>(0|0) (0|0|0)
- 1:   Oligodactyly [HP:0012165] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TB module/8-cys domain0Direct
RuvA domain 2-like0Direct
Hect, E3 ligase catalytic domain0.0007798Direct
WD40 repeat-like0.0263Inherited
Insulin-like0.02959Inherited
Restriction endonuclease-like0.02959Inherited
ARID-like0.03378Inherited
GroEL equatorial domain-like0.07448Inherited
Multidrug efflux transporter AcrB transmembrane domain0.07448Inherited
HLH, helix-loop-helix DNA-binding domain0.09947Inherited
HMG-box0.1779Inherited
Cystine-knot cytokines0.3461Inherited
vWA-like0.6673Inherited
Immunoglobulin0.6821Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.707Inherited
Class II aaRS and biotin synthetases0.9231Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
TB module/8-cys domain0Direct
Exostosin0Direct
Proteasome subunits0Direct
XPF/Rad1/Mus81 nuclease0Direct
Hect, E3 ligase catalytic domain0.0003809Direct
Erythroid transcription factor GATA-10.0007066Direct
VWC domain0.00893Inherited
Classic zinc finger, C2H20.01278Inherited
Insulin-like0.02007Inherited
ZZ domain0.02007Inherited
ARID domain0.02303Inherited
HLH, helix-loop-helix DNA-binding domain0.07265Inherited
HMG-box0.1394Inherited
RecA protein-like (ATPase-domain)0.1732Inherited
I set domains0.2943Inherited
Tetratricopeptide repeat (TPR)0.3224Inherited
Transforming growth factor (TGF)-beta0.3546Inherited
Homeodomain0.4284Inherited
Integrin A (or I) domain0.4287Inherited
Actin/HSP700.4702Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.8195Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
RuvA domain 2-like0Direct
TB module/8-cys domain0Direct
Hect, E3 ligase catalytic domain0.0004058Direct
WD40 repeat-like0.01826Inherited
Insulin-like0.02075Inherited
Restriction endonuclease-like0.02075Inherited
ARID-like0.02396Inherited
GroEL equatorial domain-like0.05703Inherited
Multidrug efflux transporter AcrB transmembrane domain0.05703Inherited
HLH, helix-loop-helix DNA-binding domain0.07811Inherited
HMG-box0.1469Inherited
Cystine-knot cytokines0.3045Inherited
Cysteine proteinases0.3634Inherited
vWA-like0.6272Inherited
TPR-like0.6417Inherited
Immunoglobulin0.6426Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.6681Inherited
Class II aaRS and biotin synthetases0.8955Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0005123Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.02075Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.02396Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.05703Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1177Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2616Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.37Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.4501Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.6681Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.02075Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08569Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1531Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.4094Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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