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Phenotypic Abnormality (PA): Generalized abnormality of skin

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the integument [HP:0001574] <4>(48|69) (59|37|15)
+ + 2:   Abnormality of the skin [HP:0000951] <4>(34|55) (45|36|12)
+ 1:   Abnormality of skin morphology [HP:0011121] <22>(29|49) (40|31|11)
0:   Generalized abnormality of skin [HP:0011354] <12>(8|12) (12|4|1)
- 1:   Vascular skin abnormality [HP:0011276] <10>(6|10) (9|2|1)
- 1:   Abnormality of subcutaneous fat tissue [HP:0001001] <6>(0|0) (0|0|0)
- 1:   Cutaneous photosensitivity [HP:0000992] <5>(0|0) (0|0|0)
- 1:   Dermatological manifestations of systemic disorders [HP:0001005] <4>(1|0) (2|1|0)
- 1:   Ectodermal dysplasia [HP:0000968] <4>(0|0) (0|0|0)
- 1:   Prematurely aged appearance [HP:0007495] <4>(0|0) (0|0|0)
- 1:   Flushing [HP:0031284] <1>(0|0) (0|0|0)
- 1:   Fragile skin [HP:0001030] <1>(0|0) (0|0|0)
- 1:   Desquamation of skin soon after birth [HP:0007549](0|0) (0|0|0)
- 1:   Generalized papillary lesions [HP:0007482](0|0) (0|0|0)
- 1:   Poor wound healing [HP:0001058](1|1) (1|1|1)
- 1:   Subcutaneous calcification [HP:0007618](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Complement control module/SCR domain0.002158Inherited
DEATH domain0.002375Inherited
Integrin domains0.045Inherited
(Trans)glycosidases0.1664Inherited
ARID-like0.1753Inherited
DNA/RNA polymerases0.2504Inherited
ABC transporter transmembrane region0.3617Inherited
HMG-box0.4503Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin reductase FAD-binding domain-like0Direct
Complement control module/SCR domain0.001628Inherited
DEATH domain, DD0.01279Inherited
Integrin domains0.03501Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.09112Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1494Inherited
ARID domain0.1494Inherited
VWC domain0.1494Inherited
Intermediate filament protein, coiled coil region0.1639Inherited
DnaQ-like 3'-5' exonuclease0.3189Inherited
HMG-box0.4199Inherited
Ngr ectodomain-like0.4284Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Complement control module/SCR domain0.001218Inherited
DEATH domain0.00135Inherited
Integrin domains0.03278Inherited
FnI-like domain0.05069Inherited
Adenine nucleotide alpha hydrolases-like0.08303Inherited
(Trans)glycosidases0.1367Inherited
ARID-like0.1447Inherited
Intermediate filament protein, coiled coil region0.154Inherited
DNA/RNA polymerases0.2137Inherited
ABC transporter transmembrane region0.3194Inherited
HMG-box0.4065Inherited
L domain-like0.7185Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.001052Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002187Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3194Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0006015Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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