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Phenotypic Abnormality (PA): Abnormality of higher mental function

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ 1:   Abnormality of nervous system physiology [HP:0012638] <26>(101|119) (112|81|39)
0:   Abnormality of higher mental function [HP:0011446] <9>(38|45) (40|24|8)
- 1:   Neurological speech impairment [HP:0002167] <20>(5|9) (5|4|1)
- 1:   Reduced consciousness/confusion [HP:0004372] <11>(11|10) (13|3|1)
- 1:   Apraxia [HP:0002186] <6>(0|0) (1|0|0)
- 1:   Intellectual disability [HP:0001249] <6>(11|11) (11|5|2)
- 1:   Agnosia [HP:0010524] <4>(2|3) (2|1|0)
- 1:   Cognitive impairment [HP:0100543] <3>(4|5) (6|4|0)
- 1:   Language impairment [HP:0002463] <1>(0|0) (0|0|0)
- 1:   Micrographia [HP:0031908](0|0) (0|0|0)
- 1:   Optic ataxia [HP:0031868](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Rhodanese/Cell cycle control phosphatase0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Methylglyoxal synthase-like0Direct
SNARE fusion complex0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
HIT-like0Direct
Lamin A/C globular tail domain0Direct
Arginase/deacetylase0Direct
ADC-like0Direct
CRAL/TRIO domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Pseudouridine synthase0Direct
L-aspartase-like0Direct
4Fe-4S ferredoxins0Direct
Proton glutamate symport protein0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
PP2C-like0Direct
LuxS/MPP-like metallohydrolase0Direct
BRK domain-like0Direct
Single hybrid motif0.01683Inherited
Bromodomain0.0501Inherited
(Trans)glycosidases0.06884Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.1206Inherited
NagB/RpiA/CoA transferase-like0.1734Inherited
PreATP-grasp domain0.1853Inherited
Glycosyl hydrolase domain0.2292Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.2835Inherited
GST C-terminal domain-like0.2835Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2859Inherited
Acyl-CoA dehydrogenase NM domain-like0.2859Inherited
ClpP/crotonase0.3571Inherited
Mitochondrial carrier0.3595Inherited
CoA-dependent acyltransferases0.3949Inherited
RNA-binding domain, RBD0.5406Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.6573Inherited
Ribosomal protein S5 domain 2-like0.6588Inherited
Intermediate filament protein, coiled coil region0.8485Inherited
Adenine nucleotide alpha hydrolases-like0.9517Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Amylase, catalytic domain0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Ferredoxin domains from multidomain proteins0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Lamin A/C globular tail domain0Direct
Glycosyl transferases group 10Direct
SNARE fusion complex0Direct
Phosphate binding protein-like0Direct
BRK domain-like0Direct
beta-glycanases0Direct
MPP-like0Direct
PP2C-like0Direct
CUT domain0Direct
Proton glutamate symport protein0Direct
CAT-like0Direct
Histone deacetylase, HDAC0Direct
L-aspartase/fumarase0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0Direct
Exostosin0Direct
Histone lysine methyltransferases0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
UBA domain0Direct
PWWP domain0Direct
IF2B-like0Direct
Extended AAA-ATPase domain0.0004032Direct
Biotinyl/lipoyl-carrier proteins and domains0.011Inherited
Bromodomain0.03702Inherited
L-arabinose binding protein-like0.0411Inherited
BC N-terminal domain-like0.05282Inherited
BC ATP-binding domain-like0.05282Inherited
DNA gyrase/MutL, second domain0.087Inherited
DNA gyrase/MutL, N-terminal domain0.087Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2856Inherited
Nicotinic receptor ligand binding domain-like0.2856Inherited
Clathrin coat assembly domain0.3095Inherited
Mitochondrial carrier0.316Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.3519Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.3519Inherited
Canonical RBD0.5426Inherited
ABC transporter ATPase domain-like0.7282Inherited
Intermediate filament protein, coiled coil region0.8146Inherited
Complement control module/SCR domain0.865Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
LuxS/MPP-like metallohydrolase0Direct
BRK domain-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Pseudouridine synthase0Direct
Proton glutamate symport protein0Direct
L-aspartase-like0Direct
PP2C-like0Direct
CRAL/TRIO domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
SNARE fusion complex0Direct
HIT-like0Direct
Arginase/deacetylase0Direct
Lamin A/C globular tail domain0Direct
4Fe-4S ferredoxins0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Methylglyoxal synthase-like0Direct
ADC-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Single hybrid motif0.01129Inherited
Bromodomain0.03691Inherited
(Trans)glycosidases0.05236Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.09616Inherited
NagB/RpiA/CoA transferase-like0.143Inherited
PreATP-grasp domain0.1536Inherited
Glycosyl hydrolase domain0.1941Inherited
GST C-terminal domain-like0.2448Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.2448Inherited
Acyl-CoA dehydrogenase NM domain-like0.2471Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2471Inherited
Nicotinic receptor ligand binding domain-like0.2865Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2865Inherited
ClpP/crotonase0.3149Inherited
Mitochondrial carrier0.3172Inherited
CoA-dependent acyltransferases0.3516Inherited
RNA-binding domain, RBD0.4965Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.6167Inherited
Ribosomal protein S5 domain 2-like0.6182Inherited
Intermediate filament protein, coiled coil region0.8158Inherited
Adenine nucleotide alpha hydrolases-like0.9264Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    50447,-8
  • 50447 - Translation proteins
  • -8 - ECOD
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    -8,54980
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.0873Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.1428Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1941Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1941Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.2471Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.2865Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.3516Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8228Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    50447,-8,54980
  • 50447 - Translation proteins
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8753Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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