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Phenotypic Abnormality (PA): Neoplasm by anatomical site

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Neoplasm [HP:0002664] <2>(20|22) (24|7|4)
0:   Neoplasm by anatomical site [HP:0011793] <24>(19|19) (22|6|3)
- 1:   Neoplasm of the skin [HP:0008069] <29>(4|5) (4|2|1)
- 1:   Neoplasm of the gastrointestinal tract [HP:0007378] <16>(6|6) (6|4|1)
- 1:   Neoplasm of the skeletal system [HP:0010622] <10>(2|2) (2|1|0)
- 1:   Hematological neoplasm [HP:0004377] <7>(2|3) (3|1|0)
- 1:   Neoplasm of the endocrine system [HP:0100568] <6>(6|5) (6|3|0)
- 1:   Neoplasm of the heart [HP:0100544] <6>(0|0) (0|0|0)
- 1:   Neoplasm of the eye [HP:0100012] <5>(0|0) (0|0|0)
- 1:   Neoplasm of the oral cavity [HP:0100649] <5>(0|0) (0|0|0)
- 1:   Malignant mesothelioma [HP:0100001] <4>(0|0) (0|0|0)
- 1:   Neoplasm of head and neck [HP:0012288] <4>(0|0) (0|0|0)
- 1:   Neoplasm of the breast [HP:0100013] <4>(2|2) (2|0|0)
- 1:   Neoplasm of the genitourinary tract [HP:0007379] <4>(6|7) (8|2|1)
- 1:   Neoplasm of the pancreas [HP:0002894] <4>(3|3) (4|1|0)
- 1:   Neoplasm of the respiratory system [HP:0100606] <4>(2|0) (2|0|0)
- 1:   Neoplasm of the ear [HP:0012780] <3>(0|0) (0|0|0)
- 1:   Neoplasm of striated muscle [HP:0009728] <2>(0|0) (0|0|0)
- 1:   Neoplasm of the nervous system [HP:0004375] <2>(3|5) (3|2|0)
- 1:   Soft tissue neoplasm [HP:0031459] <2>(0|0) (0|0|0)
- 1:   Vascular neoplasm [HP:0100742] <2>(2|1) (2|0|0)
- 1:   Neoplasm of fatty tissue [HP:0200013] <1>(0|0) (0|0|0)
- 1:   Neoplasm of the nail [HP:0100826] <1>(0|0) (0|0|0)
- 1:   Neoplasm of the thymus [HP:0100521] <1>(0|0) (0|0|0)
- 1:   Neoplasm of the lip [HP:0100604](0|0) (0|0|0)
- 1:   Retroperitoneal chemodectomas [HP:0006729](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DNA-glycosylase0Direct
TNF receptor-like0.004221Inherited
DNA repair protein MutS, domain III0.01117Inherited
Ribosomal protein S5 domain 2-like0.01303Inherited
Ribonuclease H-like0.01905Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0282Inherited
Sema domain0.04127Inherited
BRCT domain0.06415Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07718Inherited
Plexin repeat0.1557Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1775Inherited
Nuclear receptor ligand-binding domain0.1926Inherited
Intermediate filament protein, coiled coil region0.227Inherited
(Phosphotyrosine protein) phosphatases II0.2627Inherited
DEATH domain0.7071Inherited
Ankyrin repeat0.7071Inherited
Ubiquitin-like0.7478Inherited
Protein kinase-like (PK-like)1Inherited
Snake toxin-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
DIX domain0Direct
DNA gyrase/MutL, second domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
DNA repair protein MutS, domain III0.008191Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.008191Inherited
Sema domain0.03366Inherited
Ras-binding domain, RBD0.04998Inherited
POU-specific domain0.04998Inherited
RING finger domain, C3HC40.07436Inherited
DEATH domain, DD0.09632Inherited
Plexin repeat0.1411Inherited
Laminin-type module0.1758Inherited
Nuclear receptor ligand-binding domain0.1809Inherited
Intermediate filament protein, coiled coil region0.2179Inherited
Ankyrin repeat0.6666Inherited
Tandem AAA-ATPase domain0.6887Inherited
ABC transporter ATPase domain-like0.8098Inherited
RecA protein-like (ATPase-domain)0.8646Inherited
Protein kinases, catalytic subunit1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DNA-glycosylase0Direct
TNF receptor-like0.002595Inherited
DNA repair protein MutS, domain III0.007376Inherited
Ribosomal protein S5 domain 2-like0.008665Inherited
RING/U-box0.01168Inherited
Ribonuclease H-like0.01307Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02001Inherited
Sema domain0.03023Inherited
BRCT domain0.04882Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.05975Inherited
p53-like transcription factors0.07091Inherited
Plexin repeat0.1279Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1475Inherited
lambda repressor-like DNA-binding domains0.1486Inherited
Nuclear receptor ligand-binding domain0.1613Inherited
Intermediate filament protein, coiled coil region0.193Inherited
(Phosphotyrosine protein) phosphatases II0.2265Inherited
Ankyrin repeat0.669Inherited
DEATH domain0.669Inherited
Ubiquitin-like0.7116Inherited
Protein kinase-like (PK-like)0.989Inherited
Snake toxin-like0.991Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.003829Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.007376Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.007376Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.007376Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.03023Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01542Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1636Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1906Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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