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Phenotypic Abnormality (PA): Abnormal homeostasis

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(75|82) (79|40|16)
0:   Abnormal homeostasis [HP:0012337] <8>(44|47) (44|22|8)
- 1:   Abnormal glucose homeostasis [HP:0011014] <7>(11|12) (12|7|4)
- 1:   Abnormality of acid-base homeostasis [HP:0004360] <7>(19|16) (19|7|2)
- 1:   Abnormality of temperature regulation [HP:0004370] <6>(10|13) (10|6|2)
- 1:   Abnormal energy expenditure [HP:0012338] <2>(0|0) (0|0|0)
- 1:   Abnormal sweat homeostasis [HP:0040127] <2>(0|0) (0|0|0)
- 1:   Abnormality of fluid regulation [HP:0011032] <2>(8|9) (7|2|1)
- 1:   Food intolerance [HP:0012537] <1>(0|0) (0|0|0)
- 1:   Excessive purine production [HP:0003142](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Plakin repeat0Direct
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Apolipoprotein A-I0Direct
MHC antigen-recognition domain0.00638Inherited
Transcription factor STAT-4 N-domain0.007751Inherited
STAT0.007751Inherited
ClpP/crotonase0.01429Inherited
Ras GEF0.01893Inherited
Thiolase-like0.01893Inherited
HD-domain/PDEase-like0.02815Inherited
PreATP-grasp domain0.02815Inherited
GAF domain-like0.04394Inherited
Terpenoid synthases0.04394Inherited
Rudiment single hybrid motif0.04394Inherited
Insulin-like0.04394Inherited
Glutathione synthetase ATP-binding domain-like0.04812Inherited
Ribonuclease H-like0.06162Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.08363Inherited
Translation proteins0.1068Inherited
Class II aaRS and biotin synthetases0.1218Inherited
4-helical cytokines0.1228Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1266Inherited
Acyl-CoA dehydrogenase NM domain-like0.1266Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1594Inherited
Mitochondrial carrier0.191Inherited
SH2 domain0.1925Inherited
SCOP hierarchy in SUPERFAMILY0.2012Inherited
Nucleotidylyl transferase0.2128Inherited
Adenine nucleotide alpha hydrolases-like0.2166Inherited
DEATH domain0.2336Inherited
Single hybrid motif0.2692Inherited
RNI-like0.2931Inherited
4Fe-4S ferredoxins0.2953Inherited
Fibrinogen C-terminal domain-like0.2963Inherited
Complement control module/SCR domain0.5064Inherited
Voltage-gated potassium channels0.5711Inherited
E set domains0.5927Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.7143Inherited
Trypsin-like serine proteases0.721Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.8158Inherited
Nicotinic receptor ligand binding domain-like0.8158Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Amylase, catalytic domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Apolipoprotein A-I0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Smc hinge domain0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Long-chain cytokines0Direct
Plakin repeat0Direct
HCDH C-domain-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Fibrinogen coiled-coil and central regions0Direct
IF2B-like0Direct
MHC antigen-recognition domain0.004863Inherited
BC N-terminal domain-like0.0057Inherited
Transcription factor STAT-4 N-domain0.0057Inherited
STAT DNA-binding domain0.0057Inherited
STAT0.0057Inherited
BC ATP-binding domain-like0.0057Inherited
Ras GEF0.01448Inherited
Pyrin domain, PYD0.01448Inherited
Insulin-like0.03535Inherited
GAF domain0.03535Inherited
BC C-terminal domain-like0.03535Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.03535Inherited
Crotonase-like0.04462Inherited
PDEase0.04598Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.07358Inherited
Caspase recruitment domain, CARD0.09204Inherited
28-residue LRR0.09923Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.1263Inherited
Cytoplasmic domain of inward rectifier potassium channel0.1381Inherited
G proteins0.1617Inherited
Mitochondrial carrier0.1712Inherited
SH2 domain0.1762Inherited
Ras-binding domain, RBD0.1918Inherited
Biotinyl/lipoyl-carrier proteins and domains0.2437Inherited
Branched-chain alpha-keto acid dehydrogenase Pyr module0.2657Inherited
Branched-chain alpha-keto acid dehydrogenase PP module0.2657Inherited
Fibrinogen C-terminal domain-like0.2766Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.3193Inherited
Complement control module/SCR domain0.4821Inherited
Phosphotyrosine-binding domain (PTB)0.505Inherited
Eukaryotic proteases0.6383Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.8113Inherited
Nicotinic receptor ligand binding domain-like0.8113Inherited
Voltage-gated potassium channels0.8374Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Plakin repeat0Direct
Apolipoprotein A-I0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
MHC antigen-recognition domain0.003962Inherited
Transcription factor STAT-4 N-domain0.004896Inherited
STAT0.004896Inherited
ClpP/crotonase0.00946Inherited
Ras GEF0.01277Inherited
Thiolase-like0.01277Inherited
PreATP-grasp domain0.01966Inherited
HD-domain/PDEase-like0.01966Inherited
Insulin-like0.03188Inherited
Terpenoid synthases0.03188Inherited
GAF domain-like0.03188Inherited
Rudiment single hybrid motif0.03188Inherited
Glutathione synthetase ATP-binding domain-like0.03526Inherited
Ribonuclease H-like0.04636Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.06465Inherited
Translation proteins0.08415Inherited
Class II aaRS and biotin synthetases0.09725Inherited
4-helical cytokines0.09813Inherited
Acyl-CoA dehydrogenase NM domain-like0.1016Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1016Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1306Inherited
Mitochondrial carrier0.1591Inherited
SH2 domain0.1604Inherited
Nucleotidylyl transferase0.1791Inherited
Adenine nucleotide alpha hydrolases-like0.1825Inherited
DEATH domain0.1981Inherited
Single hybrid motif0.2312Inherited
RNI-like0.2535Inherited
4Fe-4S ferredoxins0.2556Inherited
Fibrinogen C-terminal domain-like0.2566Inherited
Complement control module/SCR domain0.4621Inherited
Voltage-gated potassium channels0.5281Inherited
E set domains0.5499Inherited
Homeodomain-like0.6684Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.6757Inherited
Trypsin-like serine proteases0.6826Inherited
Nicotinic receptor ligand binding domain-like0.7813Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7813Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.001784Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.003962Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.004896Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.004896Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.004896Inherited
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0.01277Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01277Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03188Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03188Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.03188Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.03188Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.0404Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1016Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.1306Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3166Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.7813Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.004896Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.004896Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.03188Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03188Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1825Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3855Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.4756Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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