SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormality of brain morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(140|161) (154|97|43)
+ + 2:   Abnormality of nervous system morphology [HP:0012639] <5>(70|93) (79|45|15)
+ 1:   Morphological abnormality of the central nervous system [HP:0002011] <17>(62|82) (71|38|15)
0:   Abnormality of brain morphology [HP:0012443] <13>(45|61) (53|29|13)
- 1:   Abnormality of the cerebral ventricles [HP:0002118] <11>(3|3) (4|0|2)
- 1:   Abnormality of brainstem morphology [HP:0002363] <10>(3|2) (3|1|0)
- 1:   Abnormality of the cerebral vasculature [HP:0100659] <7>(8|11) (11|4|1)
- 1:   Abnormality of forebrain morphology [HP:0100547] <5>(24|26) (29|13|4)
- 1:   Abnormality of the pituitary gland [HP:0012503] <5>(7|9) (7|2|0)
- 1:   Abnormality of pineal morphology [HP:0012681] <4>(0|0) (0|0|0)
- 1:   Holoprosencephaly [HP:0001360] <4>(1|1) (1|0|0)
- 1:   Abnormality of midbrain morphology [HP:0002418] <3>(1|0) (1|0|0)
- 1:   Brain atrophy [HP:0012444] <3>(1|4) (1|2|0)
- 1:   Abnormality of hindbrain morphology [HP:0011282] <2>(6|6) (7|2|1)
- 1:   Iron accumulation in brain [HP:0012675] <2>(0|0) (0|0|0)
- 1:   Copper accumulation in brain [HP:0012676](0|0) (0|0|0)
- 1:   Kernicterus [HP:0001343](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Pseudouridine synthase0Direct
Lamin A/C globular tail domain0Direct
CCCH zinc finger0Direct
Smc hinge domain0Direct
4Fe-4S ferredoxins0Direct
Restriction endonuclease-like0Direct
Subtilisin-like0Direct
ThrRS/AlaRS common domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
SAND domain-like0Direct
BRK domain-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Fibrinogen coiled-coil and central regions0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
ADC-like0Direct
HMG-box0.007781Inherited
WD40 repeat-like0.02186Inherited
GLA-domain0.02905Inherited
ARM repeat0.04592Inherited
ARID-like0.04941Inherited
Fibrinogen C-terminal domain-like0.1105Inherited
SET domain0.1211Inherited
NagB/RpiA/CoA transferase-like0.1295Inherited
Adenine nucleotide alpha hydrolases-like0.1295Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.252Inherited
Nucleotide-diphospho-sugar transferases0.3309Inherited
Integrin domains0.3399Inherited
Ribosomal protein S5 domain 2-like0.4252Inherited
MIR domain0.4405Inherited
Tubulin nucleotide-binding domain-like0.543Inherited
Tubulin C-terminal domain-like0.578Inherited
Actin-like ATPase domain0.578Inherited
Ribonuclease H-like0.578Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6192Inherited
Nuclear receptor ligand-binding domain0.6469Inherited
p53-like transcription factors0.6694Inherited
Snake toxin-like0.696Inherited
Homeodomain-like0.6968Inherited
MHC antigen-recognition domain0.7897Inherited
Cytochrome P4500.8879Inherited
Complement control module/SCR domain0.9782Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
Translational machinery components0Direct
Protein serine/threonine phosphatase0Direct
CCCH zinc finger0Direct
Lamin A/C globular tail domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
BRK domain-like0Direct
Ferredoxin domains from multidomain proteins0Direct
Smc hinge domain0Direct
Subtilases0Direct
Fibrinogen coiled-coil and central regions0Direct
L-aspartase/fumarase0Direct
EF-G/eEF-2 domains III and V0Direct
IF2B-like0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Clathrin adaptor core protein0Direct
N-acetyl transferase, NAT0Direct
Putative glucosidase YicI, domain 30Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
SWIRM domain0Direct
Histone deacetylase, HDAC0Direct
Elongation factors0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.00282Inherited
Histone lysine methyltransferases0.003112Inherited
HMG-box0.00468Inherited
G proteins0.006162Inherited
GLA-domain0.02006Inherited
ARID domain0.03589Inherited
DNA gyrase/MutL, second domain0.06456Inherited
DNA gyrase/MutL, N-terminal domain0.06456Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0647Inherited
Fibrinogen C-terminal domain-like0.08699Inherited
Tetramerization domain of potassium channels0.1049Inherited
beta-glycanases0.1121Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.1308Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.1308Inherited
Tyrosine-dependent oxidoreductases0.196Inherited
Clathrin coat assembly domain0.2495Inherited
Integrin domains0.296Inherited
Extended AAA-ATPase domain0.2993Inherited
MIR domain0.3963Inherited
Transducin (alpha subunit), insertion domain0.4062Inherited
Bromodomain0.4571Inherited
Tubulin, GTPase domain0.4908Inherited
Tubulin, C-terminal domain0.5269Inherited
Nuclear receptor ligand-binding domain0.6028Inherited
Nuclear receptor0.6141Inherited
Myosin rod fragments0.6268Inherited
Actin/HSP700.6532Inherited
PDZ domain0.7256Inherited
Transforming growth factor (TGF)-beta0.7333Inherited
MHC antigen-recognition domain0.756Inherited
Homeodomain0.8079Inherited
I set domains0.8081Inherited
Cytochrome P4500.8195Inherited
Complement control module/SCR domain0.9666Inherited
Rhodopsin-like0.9774Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Pseudouridine synthase0Direct
Fibrinogen coiled-coil and central regions0Direct
4Fe-4S ferredoxins0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
ADC-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Subtilisin-like0Direct
Smc hinge domain0Direct
ThrRS/AlaRS common domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Lamin A/C globular tail domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
SAND domain-like0Direct
Restriction endonuclease-like0Direct
BRK domain-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
CCCH zinc finger0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Nucleotidylyl transferase0.001749Inherited
HMG-box0.005023Inherited
WD40 repeat-like0.01516Inherited
GLA-domain0.02066Inherited
ARM repeat0.03391Inherited
ARID-like0.03672Inherited
Fibrinogen C-terminal domain-like0.08818Inherited
SET domain0.0973Inherited
NagB/RpiA/CoA transferase-like0.1048Inherited
Adenine nucleotide alpha hydrolases-like0.1048Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2161Inherited
Protein kinase-like (PK-like)0.2821Inherited
Nucleotide-diphospho-sugar transferases0.2915Inherited
Integrin domains0.3001Inherited
Ribosomal protein S5 domain 2-like0.383Inherited
MIR domain0.3981Inherited
Transducin (alpha subunit), insertion domain0.4098Inherited
Bromodomain0.4675Inherited
Tubulin nucleotide-binding domain-like0.5004Inherited
4-helical cytokines0.5125Inherited
Ribonuclease H-like0.5358Inherited
Tubulin C-terminal domain-like0.5358Inherited
Actin-like ATPase domain0.5358Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5781Inherited
Nuclear receptor ligand-binding domain0.6071Inherited
Myosin rod fragments0.6266Inherited
p53-like transcription factors0.63Inherited
Cystine-knot cytokines0.6566Inherited
Snake toxin-like0.6576Inherited
Homeodomain-like0.6584Inherited
MHC antigen-recognition domain0.7554Inherited
Cytochrome P4500.8586Inherited
Complement control module/SCR domain0.9557Inherited
Immunoglobulin0.9997Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
-8,54980
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    50447,-8
  • 50447 - Translation proteins
  • -8 - ECOD
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.02424Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.06508Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.1048Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.113Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.195Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4098Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.5358Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.574Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.7554Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8599Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8719Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.8745Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50447,-8,54980
  • 50447 - Translation proteins
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.113Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.113Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.733Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.7554Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)