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Phenotypic Abnormality (PA): Abnormality of nervous system physiology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the nervous system [HP:0000707] <4>(140|161) (154|97|43)
0:   Abnormality of nervous system physiology [HP:0012638] <26>(102|116) (111|76|37)
- 1:   Behavioral abnormality [HP:0000708] <38>(17|24) (20|15|6)
- 1:   Abnormality of movement [HP:0100022] <19>(25|27) (29|16|4)
- 1:   Encephalopathy [HP:0001298] <11>(5|5) (5|2|0)
- 1:   Abnormality of central motor function [HP:0011442] <10>(16|20) (23|12|4)
- 1:   Abnormality of higher mental function [HP:0011446] <8>(24|24) (26|11|0)
- 1:   Seizures [HP:0001250] <8>(11|12) (11|4|1)
- 1:   Headache [HP:0002315] <7>(3|4) (3|2|0)
- 1:   Dysphagia [HP:0002015] <5>(0|0) (0|0|0)
- 1:   Neurodevelopmental abnormality [HP:0012759] <5>(33|51) (38|22|10)
- 1:   Abnormal cranial nerve physiology [HP:0031910] <4>(2|3) (3|2|0)
- 1:   Abnormality of central sensory function [HP:0011730] <4>(0|0) (0|0|0)
- 1:   Abnormal hypothalamus physiology [HP:0012285] <3>(0|0) (0|0|0)
- 1:   Abnormal nervous system electrophysiology [HP:0001311] <2>(6|7) (6|2|0)
- 1:   Abnormality of intracranial pressure [HP:0012640] <2>(2|2) (2|1|0)
- 1:   Abnormality of taste sensation [HP:0000223] <2>(0|0) (0|0|0)
- 1:   Abnormality of the sense of smell [HP:0004408] <2>(2|3) (3|2|0)
- 1:   Brain imaging abnormality [HP:0410263] <2>(0|0) (0|0|0)
- 1:   Pseudobulbar signs [HP:0002200] <2>(0|0) (0|0|0)
- 1:   Abnormal synaptic transmission [HP:0012535] <1>(6|6) (6|2|0)
- 1:   Abnormality of pineal physiology [HP:0012688] <1>(0|0) (0|0|0)
- 1:   Bulbar palsy [HP:0001283](0|0) (0|0|0)
- 1:   Bulbar signs [HP:0002483](0|0) (0|0|0)
- 1:   Cataplexy [HP:0002524](0|0) (0|0|0)
- 1:   Easy fatigability [HP:0003388](0|2) (2|1|0)
- 1:   Hypocalcemic tetany [HP:0003472](0|0) (0|0|0)
- 1:   Lhermitte's sign [HP:0032504](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Actin depolymerizing proteins0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Zn-finger domain of Sec23/240Direct
Pseudouridine synthase0Direct
Translation proteins0Direct
Hect, E3 ligase catalytic domain0Direct
Putative DNA-binding domain0Direct
HIT-like0Direct
DBL homology domain (DH-domain)0Direct
Helical domain of Sec23/240Direct
Lamin A/C globular tail domain0Direct
GAF domain-like0Direct
CCCH zinc finger0Direct
Toll/Interleukin receptor TIR domain0Direct
Thiolase-like0Direct
GroEL apical domain-like0Direct
Nicotinic receptor ligand binding domain-like0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
CRAL/TRIO domain0Direct
Smc hinge domain0Direct
4Fe-4S ferredoxins0Direct
GroEL equatorial domain-like0Direct
Restriction endonuclease-like0Direct
Subtilisin-like0Direct
Arginase/deacetylase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
CoA-dependent acyltransferases0Direct
Proton glutamate symport protein0Direct
SNARE fusion complex0Direct
RuvA domain 2-like0Direct
LuxS/MPP-like metallohydrolase0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
ThrRS/AlaRS common domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Calcium-dependent phosphotriesterase0Direct
SAND domain-like0Direct
PP2C-like0Direct
Tricorn protease domain 20Direct
beta-sandwich domain of Sec23/240Direct
BRK domain-like0Direct
FKBP-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
GroEL-intermediate domain like0Direct
Hook domain0Direct
S15/NS1 RNA-binding domain0Direct
Notch domain0Direct
JAB1/MPN domain0Direct
EF-G C-terminal domain-like0Direct
Adenine nucleotide alpha hydrolases-like0Direct
Methylglyoxal synthase-like0Direct
Ribonuclease PH domain 2-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
TB module/8-cys domain0Direct
L-aspartase-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Multidrug resistance efflux transporter EmrE0Direct
ADC-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
HMG-box0.04695Inherited
Acyl-CoA dehydrogenase NM domain-like0.07506Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.07506Inherited
Periplasmic binding protein-like II0.09526Inherited
Glutathione synthetase ATP-binding domain-like0.09526Inherited
RNI-like0.1336Inherited
Single hybrid motif0.1543Inherited
PreATP-grasp domain0.1543Inherited
Sema domain0.1543Inherited
SET domain0.1826Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1952Inherited
GST C-terminal domain-like0.1952Inherited
Voltage-gated potassium channels0.2398Inherited
ARID-like0.247Inherited
MIR domain0.247Inherited
Periplasmic binding protein-like I0.2528Inherited
Mitochondrial carrier0.2528Inherited
FabD/lysophospholipase-like0.3112Inherited
Chaperone J-domain0.3463Inherited
HAD-like0.3679Inherited
Rudiment single hybrid motif0.3948Inherited
PH domain-like0.4166Inherited
Ribosomal protein S5 domain 2-like0.4785Inherited
NagB/RpiA/CoA transferase-like0.4809Inherited
Bromodomain0.5015Inherited
HSP20-like chaperones0.5656Inherited
cAMP-binding domain-like0.5769Inherited
RNA-binding domain, RBD0.6014Inherited
ClpP/crotonase0.6231Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.6334Inherited
Tropomyosin0.6749Inherited
vWA-like0.684Inherited
Glycosyl hydrolase domain0.6953Inherited
MHC antigen-recognition domain0.7295Inherited
POZ domain0.7641Inherited
Integrin domains0.8159Inherited
Intermediate filament protein, coiled coil region0.8397Inherited
DEATH domain0.967Inherited
Immunoglobulin1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
TB module/8-cys domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
PWWP domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Translational machinery components0Direct
Protein serine/threonine phosphatase0Direct
CCCH zinc finger0Direct
PP2C-like0Direct
SNARE fusion complex0Direct
DBL homology domain (DH-domain)0Direct
Anticodon-binding domain0Direct
Glycosyl transferases group 10Direct
MPP-like0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Histone lysine methyltransferases0Direct
Lamin A/C globular tail domain0Direct
JAB1/MPN domain0Direct
DEP domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
BRK domain-like0Direct
Toll/Interleukin receptor TIR domain0Direct
a tRNA synthase domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Myotubularin-like phosphatases0Direct
Hect, E3 ligase catalytic domain0Direct
Ferredoxin domains from multidomain proteins0Direct
Zn-finger domain of Sec23/240Direct
beta-glycanases0Direct
Smc hinge domain0Direct
Caspase recruitment domain, CARD0Direct
Subtilases0Direct
Nicotinic receptor ligand binding domain-like0Direct
Amylase, catalytic domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
L-aspartase/fumarase0Direct
EF-G/eEF-2 domains III and V0Direct
Ribonuclease PH domain 1-like0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
IF2B-like0Direct
RhoGDI-like0Direct
CUT domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
p120GAP domain-like0Direct
Filamin repeat (rod domain)0Direct
Ribonuclease PH domain 2-like0Direct
Phosphate binding protein-like0Direct
Proton glutamate symport protein0Direct
Clathrin adaptor core protein0Direct
Clathrin coat assembly domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
UBA domain0Direct
FKBP immunophilin/proline isomerase0Direct
N-acetyl transferase, NAT0Direct
beta-sandwich domain of Sec23/240Direct
FAD/NAD-linked reductases, N-terminal and central domains0Direct
Prefoldin0Direct
Choline/Carnitine O-acyltransferase0Direct
Pyridoxal-dependent decarboxylase0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Exostosin0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
GAF domain0Direct
SWIRM domain0Direct
Trunk domain of Sec23/240Direct
Histone deacetylase, HDAC0Direct
Elongation factors0Direct
HMG-box0.0328Inherited
Extended AAA-ATPase domain0.0328Inherited
FHA domain0.07364Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0958Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0958Inherited
Sema domain0.1246Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1246Inherited
Plexin repeat0.1609Inherited
Tetramerization domain of potassium channels0.1609Inherited
Voltage-gated potassium channels0.1966Inherited
ARID domain0.2087Inherited
BC N-terminal domain-like0.2087Inherited
BC ATP-binding domain-like0.2087Inherited
MIR domain0.2087Inherited
Mitochondrial carrier0.2116Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2429Inherited
28-residue LRR0.2429Inherited
Pyrin domain, PYD0.2706Inherited
RecA protein-like (ATPase-domain)0.296Inherited
Chaperone J-domain0.2989Inherited
L-arabinose binding protein-like0.2989Inherited
PHD domain0.3491Inherited
BC C-terminal domain-like0.3507Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.4096Inherited
VWC domain0.4356Inherited
Bromodomain0.453Inherited
cAMP-binding domain0.5908Inherited
PDZ domain0.6091Inherited
Canonical RBD0.6128Inherited
Tropomyosin0.6349Inherited
Calcium ATPase, transduction domain A0.6555Inherited
Cadherin0.663Inherited
MHC antigen-recognition domain0.6924Inherited
Myosin rod fragments0.7157Inherited
ABC transporter ATPase domain-like0.7284Inherited
Integrin A (or I) domain0.7707Inherited
DNA gyrase/MutL, second domain0.772Inherited
DNA gyrase/MutL, N-terminal domain0.772Inherited
Integrin domains0.7857Inherited
Intermediate filament protein, coiled coil region0.8047Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Pseudouridine synthase0Direct
Methylglyoxal synthase-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
4Fe-4S ferredoxins0Direct
CoA-dependent acyltransferases0Direct
S15/NS1 RNA-binding domain0Direct
Hook domain0Direct
Hect, E3 ligase catalytic domain0Direct
Arginase/deacetylase0Direct
Notch domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
HIT-like0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
Zn-finger domain of Sec23/240Direct
SNARE fusion complex0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Helical domain of Sec23/240Direct
ADC-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
GroEL equatorial domain-like0Direct
Nicotinic receptor ligand binding domain-like0Direct
Putative DNA-binding domain0Direct
CRAL/TRIO domain0Direct
JAB1/MPN domain0Direct
TB module/8-cys domain0Direct
Ribonuclease PH domain 2-like0Direct
GroEL-intermediate domain like0Direct
Subtilisin-like0Direct
beta-sandwich domain of Sec23/240Direct
GAF domain-like0Direct
PP2C-like0Direct
Adenine nucleotide alpha hydrolases-like0Direct
Smc hinge domain0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
ThrRS/AlaRS common domain0Direct
Toll/Interleukin receptor TIR domain0Direct
Actin depolymerizing proteins0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
FKBP-like0Direct
Thiolase-like0Direct
LuxS/MPP-like metallohydrolase0Direct
Lamin A/C globular tail domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
RuvA domain 2-like0Direct
L-aspartase-like0Direct
Restriction endonuclease-like0Direct
BRK domain-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Proton glutamate symport protein0Direct
EF-G C-terminal domain-like0Direct
Translation proteins0Direct
DBL homology domain (DH-domain)0Direct
Multidrug resistance efflux transporter EmrE0Direct
GroEL apical domain-like0Direct
CCCH zinc finger0Direct
Calcium-dependent phosphotriesterase0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
HMG-box0.03477Inherited
Acyl-CoA dehydrogenase NM domain-like0.05789Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.05789Inherited
Periplasmic binding protein-like II0.07518Inherited
Glutathione synthetase ATP-binding domain-like0.07518Inherited
RNI-like0.1085Inherited
Sema domain0.1268Inherited
PreATP-grasp domain0.1268Inherited
Single hybrid motif0.1268Inherited
SET domain0.152Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1636Inherited
GST C-terminal domain-like0.1636Inherited
Plexin repeat0.1646Inherited
Voltage-gated potassium channels0.205Inherited
MIR domain0.2115Inherited
ARID-like0.2115Inherited
Periplasmic binding protein-like I0.217Inherited
Mitochondrial carrier0.217Inherited
FabD/lysophospholipase-like0.2729Inherited
Chaperone J-domain0.306Inherited
ARM repeat0.3132Inherited
HAD-like0.3271Inherited
Rudiment single hybrid motif0.3534Inherited
Nucleotidylyl transferase0.3561Inherited
PH domain-like0.3746Inherited
Ribosomal protein S5 domain 2-like0.4357Inherited
NagB/RpiA/CoA transferase-like0.438Inherited
Bromodomain0.4584Inherited
Cadherin-like0.5083Inherited
HSP20-like chaperones0.523Inherited
cAMP-binding domain-like0.5347Inherited
RNA-binding domain, RBD0.5601Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.5821Inherited
ClpP/crotonase0.5821Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.5932Inherited
Calcium ATPase, transmembrane domain M0.6001Inherited
Tropomyosin0.6357Inherited
vWA-like0.6452Inherited
Glycosyl hydrolase domain0.6568Inherited
Calcium ATPase, transduction domain A0.6584Inherited
MHC antigen-recognition domain0.6921Inherited
Myosin rod fragments0.7157Inherited
POZ domain0.7287Inherited
Integrin domains0.7832Inherited
Intermediate filament protein, coiled coil region0.8078Inherited
Ribonuclease H-like0.849Inherited
DEATH domain0.9432Inherited
Immunoglobulin0.9999Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    117281,117281
  • 117281 - Kelch motif
  • 117281 - Kelch motif
  • 0Direct
    -8,54980
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    50447,-8
  • 50447 - Translation proteins
  • -8 - ECOD
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0Direct
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.05789Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.1268Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1636Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2473Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.2582Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2729Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.3534Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.3651Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.4201Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.5821Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.6568Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.6667Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.6921Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.7683Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.8105Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.8105Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    50447,-8,54980
  • 50447 - Translation proteins
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.05789Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.306Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.3534Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.5821Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.6667Inherited


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