SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormality of nervous system morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the nervous system [HP:0000707] <4>(140|161) (154|97|43)
0:   Abnormality of nervous system morphology [HP:0012639] <5>(70|93) (79|45|15)
- 1:   Morphological abnormality of the central nervous system [HP:0002011] <17>(62|82) (71|38|15)
- 1:   Abnormal peripheral nervous system morphology [HP:0000759] <14>(14|15) (15|5|0)
- 1:   Abnormal myelination [HP:0012447] <6>(3|4) (3|0|0)
- 1:   Abnormal neuron morphology [HP:0012757] <2>(2|2) (2|1|0)
- 1:   Neoplasm of the nervous system [HP:0004375] <2>(3|5) (3|2|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Actin depolymerizing proteins0Direct
Pseudouridine synthase0Direct
Lamin A/C globular tail domain0Direct
CCCH zinc finger0Direct
Smc hinge domain0Direct
4Fe-4S ferredoxins0Direct
Restriction endonuclease-like0Direct
Subtilisin-like0Direct
RuvA domain 2-like0Direct
ThrRS/AlaRS common domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
SAND domain-like0Direct
BRK domain-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
S15/NS1 RNA-binding domain0Direct
Notch domain0Direct
Ribonuclease PH domain 2-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
ADC-like0Direct
ARM repeat0.0007848Direct
Glycosyl hydrolase domain0.03404Inherited
Ribosomal protein S5 domain 2-like0.05367Inherited
GLA-domain0.07478Inherited
Actin-like ATPase domain0.07863Inherited
RNA-binding domain, RBD0.1013Inherited
ARID-like0.1092Inherited
Tubulin nucleotide-binding domain-like0.1501Inherited
HMG-box0.1542Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1652Inherited
WD40 repeat-like0.1913Inherited
Tubulin C-terminal domain-like0.1919Inherited
SMAD/FHA domain0.2207Inherited
Anaphylotoxins (complement system)0.2302Inherited
DNA repair protein MutS, domain III0.2302Inherited
Fibrinogen C-terminal domain-like0.2498Inherited
NagB/RpiA/CoA transferase-like0.2509Inherited
Ribonuclease H-like0.3167Inherited
Nucleotide-diphospho-sugar transferases0.3248Inherited
TIMP-like0.4049Inherited
MIR domain0.4078Inherited
p53-like transcription factors0.4163Inherited
SET domain0.4584Inherited
Calcium-dependent phosphotriesterase0.488Inherited
TNF receptor-like0.4989Inherited
Alpha-macroglobulin receptor domain0.5047Inherited
Integrin domains0.5498Inherited
MHC antigen-recognition domain0.6074Inherited
Adenine nucleotide alpha hydrolases-like0.6074Inherited
Bromodomain0.6248Inherited
PH domain-like0.6322Inherited
SH2 domain0.6331Inherited
Homeodomain-like0.6579Inherited
Thioredoxin-like0.6907Inherited
Snake toxin-like0.6954Inherited
Voltage-gated potassium channels0.6991Inherited
Terpenoid cyclases/Protein prenyltransferases0.7649Inherited
RNI-like0.7737Inherited
Nuclear receptor ligand-binding domain0.9325Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.9412Inherited
Cytochrome P4500.971Inherited
DEATH domain0.9838Inherited
Nicotinic receptor ligand binding domain-like0.9858Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9858Inherited
Immunoglobulin0.989Inherited
Complement control module/SCR domain1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Translational machinery components0Direct
Protein serine/threonine phosphatase0Direct
CCCH zinc finger0Direct
Anticodon-binding domain0Direct
Glycosyl transferases group 10Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Lamin A/C globular tail domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
BRK domain-like0Direct
DNA gyrase/MutL, second domain0Direct
a tRNA synthase domain0Direct
Myotubularin-like phosphatases0Direct
Ferredoxin domains from multidomain proteins0Direct
beta-glycanases0Direct
Smc hinge domain0Direct
Subtilases0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Fibrinogen coiled-coil and central regions0Direct
L-aspartase/fumarase0Direct
EF-G/eEF-2 domains III and V0Direct
Ribonuclease PH domain 1-like0Direct
IF2B-like0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Filamin repeat (rod domain)0Direct
Ribonuclease PH domain 2-like0Direct
Clathrin adaptor core protein0Direct
UBA domain0Direct
N-acetyl transferase, NAT0Direct
Putative glucosidase YicI, domain 30Direct
Pyridoxal-dependent decarboxylase0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
DNA gyrase/MutL, N-terminal domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Exostosin0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
SWIRM domain0Direct
Histone deacetylase, HDAC0Direct
Elongation factors0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Extended AAA-ATPase domain0.002148Inherited
FHA domain0.01551Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.02301Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.03275Inherited
Actin/HSP700.03713Inherited
GLA-domain0.05773Inherited
ARID domain0.08727Inherited
Tubulin, GTPase domain0.122Inherited
Canonical RBD0.1275Inherited
HMG-box0.1284Inherited
Histone lysine methyltransferases0.1379Inherited
G proteins0.1508Inherited
Tubulin, C-terminal domain0.1591Inherited
Transforming growth factor (TGF)-beta0.1768Inherited
Glutathione S-transferase (GST), C-terminal domain0.196Inherited
DNA repair protein MutS, domain III0.196Inherited
Anaphylotoxins (complement system)0.196Inherited
Netrin-like domain (NTR/C345C module)0.196Inherited
Fibrinogen C-terminal domain-like0.2129Inherited
VWC domain0.2146Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2482Inherited
Ras-binding domain, RBD0.2936Inherited
Clathrin coat assembly domain0.3686Inherited
MIR domain0.3686Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3784Inherited
Tetramerization domain of potassium channels0.3784Inherited
C1 set domains (antibody constant domain-like)0.4555Inherited
Alpha-macroglobulin receptor domain0.4622Inherited
Complement components0.4622Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.5006Inherited
Transducin (alpha subunit), insertion domain0.5006Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.5006Inherited
Integrin domains0.508Inherited
Tyrosine-dependent oxidoreductases0.5385Inherited
MHC antigen-recognition domain0.5724Inherited
Bromodomain0.5905Inherited
SH2 domain0.5992Inherited
Myosin rod fragments0.639Inherited
Amylase, catalytic domain0.7316Inherited
Homeodomain0.7336Inherited
ABC transporter ATPase domain-like0.7597Inherited
PDZ domain0.8415Inherited
I set domains0.8548Inherited
Nuclear receptor ligand-binding domain0.918Inherited
Cytochrome P4500.9313Inherited
Nuclear receptor0.9418Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9785Inherited
Nicotinic receptor ligand binding domain-like0.9785Inherited
Complement control module/SCR domain0.9977Inherited
Rhodopsin-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Pseudouridine synthase0Direct
Fibrinogen coiled-coil and central regions0Direct
4Fe-4S ferredoxins0Direct
S15/NS1 RNA-binding domain0Direct
Notch domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
ADC-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Ribonuclease PH domain 2-like0Direct
Subtilisin-like0Direct
Smc hinge domain0Direct
ThrRS/AlaRS common domain0Direct
Actin depolymerizing proteins0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Lamin A/C globular tail domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
SAND domain-like0Direct
RuvA domain 2-like0Direct
Restriction endonuclease-like0Direct
BRK domain-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
CCCH zinc finger0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
ARM repeat0.0004219Direct
Nucleotidylyl transferase0.01729Inherited
Glycosyl hydrolase domain0.02457Inherited
Ribosomal protein S5 domain 2-like0.04025Inherited
GLA-domain0.05766Inherited
Actin-like ATPase domain0.06099Inherited
RNA-binding domain, RBD0.08027Inherited
ARID-like0.08705Inherited
Tubulin nucleotide-binding domain-like0.1232Inherited
HMG-box0.1267Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1366Inherited
WD40 repeat-like0.1601Inherited
Tubulin C-terminal domain-like0.1606Inherited
SMAD/FHA domain0.1872Inherited
DNA repair protein MutS, domain III0.196Inherited
Anaphylotoxins (complement system)0.196Inherited
Fibrinogen C-terminal domain-like0.2141Inherited
NagB/RpiA/CoA transferase-like0.2152Inherited
Protein kinase-like (PK-like)0.2636Inherited
Ribonuclease H-like0.278Inherited
Cysteine-rich domain0.278Inherited
Nucleotide-diphospho-sugar transferases0.2856Inherited
TIMP-like0.3633Inherited
MIR domain0.366Inherited
p53-like transcription factors0.3743Inherited
SET domain0.4159Inherited
Calcium-dependent phosphotriesterase0.445Inherited
TNF receptor-like0.4557Inherited
Alpha-macroglobulin receptor domain0.4616Inherited
Transducin (alpha subunit), insertion domain0.4959Inherited
Integrin domains0.507Inherited
4-helical cytokines0.5427Inherited
MHC antigen-recognition domain0.5662Inherited
Adenine nucleotide alpha hydrolases-like0.5662Inherited
Bromodomain0.5841Inherited
PH domain-like0.5918Inherited
Cystine-knot cytokines0.5928Inherited
SH2 domain0.5928Inherited
Homeodomain-like0.6183Inherited
Myosin rod fragments0.6357Inherited
Ankyrin repeat0.6517Inherited
Thioredoxin-like0.652Inherited
Snake toxin-like0.6568Inherited
Voltage-gated potassium channels0.6606Inherited
Terpenoid cyclases/Protein prenyltransferases0.7295Inherited
RNI-like0.7387Inherited
Nuclear receptor ligand-binding domain0.9054Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.9148Inherited
Cytochrome P4500.9477Inherited
DEATH domain0.962Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9644Inherited
Nicotinic receptor ligand binding domain-like0.9644Inherited
Immunoglobulin0.9679Inherited
FAD/NAD(P)-binding domain0.9759Inherited
Complement control module/SCR domain0.9834Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    -8,54980
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    50447,-8
  • 50447 - Translation proteins
  • -8 - ECOD
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.02457Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.07906Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.09123Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1312Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.1606Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.196Inherited
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.196Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.196Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.246Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.3633Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.4959Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4959Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.5189Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.5337Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.5662Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6918Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.9251Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.9644Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50447,-8,54980
  • 50447 - Translation proteins
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3756Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.445Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.445Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6106Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.6425Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6736Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)