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Phenotypic Abnormality (PA): Abnormality of nervous system morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
0:   Abnormality of nervous system morphology [HP:0012639] <5>(70|97) (81|48|16)
- 1:   Morphological abnormality of the central nervous system [HP:0002011] <17>(61|85) (71|41|16)
- 1:   Abnormal peripheral nervous system morphology [HP:0000759] <14>(14|17) (17|6|0)
- 1:   Abnormal myelination [HP:0012447] <6>(2|4) (3|0|0)
- 1:   Abnormal neuron morphology [HP:0012757] <2>(2|2) (2|1|0)
- 1:   Neoplasm of the nervous system [HP:0004375] <2>(3|6) (3|2|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Ribonuclease PH domain 2-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Lamin A/C globular tail domain0Direct
SAND domain-like0Direct
Restriction endonuclease-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Pseudouridine synthase0Direct
4Fe-4S ferredoxins0Direct
CCCH zinc finger0Direct
Actin depolymerizing proteins0Direct
S15/NS1 RNA-binding domain0Direct
RuvA domain 2-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Rhodanese/Cell cycle control phosphatase0Direct
ThrRS/AlaRS common domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
ADC-like0Direct
Smc hinge domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Subtilisin-like0Direct
Fibrinogen coiled-coil and central regions0Direct
ARM repeat0.0005443Direct
Nucleotidylyl transferase0.0292Inherited
Glycosyl hydrolase domain0.03726Inherited
Class II aaRS and biotin synthetases0.04223Inherited
Ribosomal protein S5 domain 2-like0.06072Inherited
GLA-domain0.07964Inherited
Actin-like ATPase domain0.08763Inherited
ARID-like0.1154Inherited
Kelch motif0.1614Inherited
Tubulin nucleotide-binding domain-like0.1614Inherited
p53-like transcription factors0.1745Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.1774Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1774Inherited
Tubulin C-terminal domain-like0.2047Inherited
Anaphylotoxins (complement system)0.2384Inherited
DNA repair protein MutS, domain III0.2384Inherited
WD40 repeat-like0.2602Inherited
NagB/RpiA/CoA transferase-like0.2615Inherited
Fibrinogen C-terminal domain-like0.2621Inherited
RNA-binding domain, RBD0.3036Inherited
Nucleotide-diphospho-sugar transferases0.3198Inherited
Ribonuclease H-like0.3382Inherited
MHC antigen-recognition domain0.3913Inherited
Thioredoxin-like0.4138Inherited
Alpha-macroglobulin receptor domain0.4195Inherited
SET domain0.4842Inherited
Calcium-dependent phosphotriesterase0.5032Inherited
TIMP-like0.5662Inherited
Integrin domains0.5662Inherited
Adenine nucleotide alpha hydrolases-like0.625Inherited
SH2 domain0.6255Inherited
Homeodomain-like0.6338Inherited
Bromodomain0.6504Inherited
Myosin rod fragments0.69Inherited
Terpenoid cyclases/Protein prenyltransferases0.69Inherited
Snake toxin-like0.712Inherited
PH domain-like0.7395Inherited
Voltage-gated potassium channels0.7449Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8723Inherited
RNI-like0.8987Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9816Inherited
Nicotinic receptor ligand binding domain-like0.9816Inherited
Nuclear receptor ligand-binding domain0.9816Inherited
DEATH domain0.9993Inherited
Immunoglobulin0.9997Inherited
Cytochrome P4501Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
Ribonuclease PH domain 1-like0Direct
a tRNA synthase domain0Direct
Putative glucosidase YicI, domain 30Direct
Ferredoxin domains from multidomain proteins0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Smc hinge domain0Direct
Anticodon-binding domain0Direct
DNA gyrase/MutL, second domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Notch domain0Direct
beta-glycanases0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Long-chain cytokines0Direct
Translational machinery components0Direct
Subtilases0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Glycosyl transferases group 10Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Fibrinogen coiled-coil and central regions0Direct
Clathrin adaptor core protein0Direct
SPRY domain0Direct
IF2B-like0Direct
N-acetyl transferase, NAT0Direct
CCCH zinc finger0Direct
CAT-like0Direct
Histone deacetylase, HDAC0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0Direct
Exostosin0Direct
UBA domain0Direct
Filamin repeat (rod domain)0Direct
Ribonuclease PH domain 2-like0Direct
DNA gyrase/MutL, N-terminal domain0Direct
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0Direct
Lamin A/C globular tail domain0Direct
L-aspartase/fumarase0Direct
SWIRM domain0Direct
EF-G/eEF-2 domains III and V0Direct
Myotubularin-like phosphatases0Direct
Protein serine/threonine phosphatase0Direct
Elongation factors0Direct
Extended AAA-ATPase domain0.002397Inherited
FHA domain0.01669Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.01768Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.03594Inherited
Actin/HSP700.03932Inherited
GLA-domain0.0599Inherited
ARID domain0.0896Inherited
Kelch motif0.1269Inherited
Tubulin, GTPase domain0.1269Inherited
HMG-box0.1362Inherited
Histone lysine methyltransferases0.1436Inherited
Tubulin, C-terminal domain0.1649Inherited
G proteins0.1661Inherited
Transforming growth factor (TGF)-beta0.1862Inherited
Glutathione S-transferase (GST), C-terminal domain0.1999Inherited
Netrin-like domain (NTR/C345C module)0.1999Inherited
DNA repair protein MutS, domain III0.1999Inherited
Anaphylotoxins (complement system)0.1999Inherited
PHD domain0.2052Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.211Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.211Inherited
Fibrinogen C-terminal domain-like0.2188Inherited
VWC domain0.2195Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2556Inherited
Ras-binding domain, RBD0.2992Inherited
T-box0.3141Inherited
C1 set domains (antibody constant domain-like)0.3141Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3378Inherited
MHC antigen-recognition domain0.3404Inherited
Alpha-macroglobulin receptor domain0.3703Inherited
Complement components0.3703Inherited
Canonical RBD0.3793Inherited
Tetramerization domain of potassium channels0.3907Inherited
Tyrosine-dependent oxidoreductases0.5057Inherited
Transducin (alpha subunit), insertion domain0.5109Inherited
Integrin domains0.5156Inherited
SH2 domain0.5754Inherited
Crotonase-like0.5851Inherited
Bromodomain0.6042Inherited
Myosin rod fragments0.6465Inherited
MIR domain0.6584Inherited
Homeodomain0.6807Inherited
Amylase, catalytic domain0.7404Inherited
ABC transporter ATPase domain-like0.8258Inherited
PDZ domain0.8345Inherited
Second domain of FERM0.8451Inherited
Nicotinic receptor ligand binding domain-like0.9692Inherited
Nuclear receptor ligand-binding domain0.9692Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9692Inherited
Cytochrome P4500.9817Inherited
Nuclear receptor0.983Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Subtilisin-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
SAND domain-like0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
S15/NS1 RNA-binding domain0Direct
ADC-like0Direct
Smc hinge domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Restriction endonuclease-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Lamin A/C globular tail domain0Direct
Actin depolymerizing proteins0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Fibrinogen coiled-coil and central regions0Direct
Notch domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Ribonuclease PH domain 2-like0Direct
CCCH zinc finger0Direct
4Fe-4S ferredoxins0Direct
RuvA domain 2-like0Direct
ThrRS/AlaRS common domain0Direct
Pseudouridine synthase0Direct
ARM repeat0.0002842Direct
Nucleotidylyl transferase0.02058Inherited
Glycosyl hydrolase domain0.02696Inherited
Class II aaRS and biotin synthetases0.03082Inherited
Ribosomal protein S5 domain 2-like0.04606Inherited
GLA-domain0.06165Inherited
Actin-like ATPase domain0.06838Inherited
Cysteine proteinases0.08047Inherited
ARID-like0.0921Inherited
Kelch motif0.133Inherited
Tubulin nucleotide-binding domain-like0.133Inherited
HMG-box0.1413Inherited
p53-like transcription factors0.1445Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1472Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.1472Inherited
Tubulin C-terminal domain-like0.1724Inherited
DNA repair protein MutS, domain III0.2034Inherited
Anaphylotoxins (complement system)0.2034Inherited
WD40 repeat-like0.2237Inherited
NagB/RpiA/CoA transferase-like0.2251Inherited
Fibrinogen C-terminal domain-like0.2257Inherited
SMAD/FHA domain0.235Inherited
RNA-binding domain, RBD0.2651Inherited
Nucleotide-diphospho-sugar transferases0.2805Inherited
Ribonuclease H-like0.2981Inherited
MHC antigen-recognition domain0.3494Inherited
Thioredoxin-like0.3713Inherited
Alpha-macroglobulin receptor domain0.3768Inherited
SET domain0.4405Inherited
Calcium-dependent phosphotriesterase0.4598Inherited
Transducin (alpha subunit), insertion domain0.5163Inherited
PDZ domain-like0.519Inherited
Integrin domains0.5239Inherited
TIMP-like0.5239Inherited
Adenine nucleotide alpha hydrolases-like0.5853Inherited
SH2 domain0.5858Inherited
TNF receptor-like0.5911Inherited
Homeodomain-like0.5942Inherited
Bromodomain0.6111Inherited
Cystine-knot cytokines0.6257Inherited
Terpenoid cyclases/Protein prenyltransferases0.6518Inherited
Myosin rod fragments0.6518Inherited
MIR domain0.6596Inherited
Snake toxin-like0.6741Inherited
PH domain-like0.7029Inherited
Voltage-gated potassium channels0.7083Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8413Inherited
RNI-like0.8697Inherited
Second domain of FERM0.9321Inherited
FAD/NAD(P)-binding domain0.9405Inherited
Nicotinic receptor ligand binding domain-like0.9594Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9594Inherited
Nuclear receptor ligand-binding domain0.9594Inherited
DEATH domain0.9796Inherited
Immunoglobulin0.9802Inherited
Cytochrome P4500.9824Inherited
Complement control module/SCR domain0.996Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    49265,49899
  • 49265 - Fibronectin type III
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    -8,54980
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    50447,-8
  • 50447 - Translation proteins
  • -8 - ECOD
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.02696Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.06063Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1007Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1375Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.1724Inherited
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.2034Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2034Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.2034Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.2599Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.2933Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3494Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.5163Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.5445Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6119Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.719Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8728Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.9594Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.9758Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    50447,-8,54980
  • 50447 - Translation proteins
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04093Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3966Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.4598Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4598Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.6596Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7559Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8338Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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