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Phenotypic Abnormality (PA): Increased inflammatory response

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
+ + 2:   Abnormality of immune system physiology [HP:0010978] <14>(29|37) (31|22|11)
+ 1:   Abnormal inflammatory response [HP:0012647] <2>(17|20) (18|11|3)
0:   Increased inflammatory response [HP:0012649] <27>(15|18) (16|9|3)
- 1:   Inflammatory abnormality of the skin [HP:0011123] <17>(3|4) (4|3|0)
- 1:   Hepatitis [HP:0012115] <7>(0|0) (0|0|0)
- 1:   Inflammatory abnormality of the eye [HP:0100533] <6>(6|7) (6|3|0)
- 1:   Cholangitis [HP:0030151] <5>(0|0) (0|0|0)
- 1:   Osteomyelitis [HP:0002754] <4>(0|0) (0|0|0)
- 1:   Otitis media [HP:0000388] <4>(0|3) (0|1|1)
- 1:   Pancreatitis [HP:0001733] <4>(0|0) (0|0|0)
- 1:   Gastrointestinal inflammation [HP:0004386] <3>(2|1) (4|0|0)
- 1:   Nephritis [HP:0000123] <3>(2|3) (2|1|0)
- 1:   Periodontitis [HP:0000704] <3>(1|1) (1|0|0)
- 1:   Sinusitis [HP:0000246] <3>(0|0) (0|0|1)
- 1:   Endocarditis [HP:0100584] <2>(1|0) (1|0|0)
- 1:   Pneumonia [HP:0002090] <2>(1|0) (1|0|0)
- 1:   Serositis [HP:0045073] <2>(2|2) (2|1|0)
- 1:   Fasciitis [HP:0100537] <1>(0|0) (0|0|0)
- 1:   Optic neuritis [HP:0100653] <1>(2|1) (2|1|0)
- 1:   Stomatitis [HP:0010280] <1>(6|7) (6|5|2)
- 1:   Thyroiditis [HP:0100646] <1>(1|1) (1|0|0)
- 1:   Chondritis [HP:0100662](0|0) (0|0|0)
- 1:   Epididymitis [HP:0000031](0|0) (0|0|0)
- 1:   Lymphadenitis [HP:0002840](0|0) (0|0|0)
- 1:   Myelitis [HP:0012486](0|0) (0|0|0)
- 1:   Myositis [HP:0100614](0|0) (1|0|0)
- 1:   Panniculitis [HP:0012490](1|1) (1|0|0)
- 1:   Prostatitis [HP:0000024](0|0) (0|0|0)
- 1:   Urinary bladder inflammation [HP:0100577](0|0) (0|0|0)
- 1:   Vaginitis [HP:0030683](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
4-helical cytokines1Inherited
Transcription factor STAT-4 N-domain1Inherited
STAT1Inherited
Glucocorticoid receptor-like (DNA-binding domain)1Inherited
RNI-like1Inherited
Trypsin-like serine proteases1Inherited
DEATH domain1Inherited
Cysteine-rich domain1Inherited
MHC antigen-recognition domain1Inherited
TNF-like1Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)1Inherited
Immunoglobulin1Inherited
SH2 domain1Inherited
TNF receptor-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)1Inherited
DEATH domain, DD1Inherited
STAT1Inherited
Rel/Dorsal transcription factors, DNA-binding domain1Inherited
Pyrin domain, PYD1Inherited
PLC-like (P variant)1Inherited
STAT DNA-binding domain1Inherited
Noncollagenous (NC1) domain of collagen IV1Inherited
SH2 domain1Inherited
Proteasome subunits1Inherited
Caspase recruitment domain, CARD1Inherited
Eukaryotic proteases1Inherited
28-residue LRR1Inherited
PHD domain1Inherited
Transcription factor STAT-4 N-domain1Inherited
MHC antigen-recognition domain1Inherited
C1 set domains (antibody constant domain-like)1Inherited
TNF-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
STAT1Inherited
4-helical cytokines1Inherited
SH2 domain1Inherited
Trypsin-like serine proteases1Inherited
Transcription factor STAT-4 N-domain1Inherited
Immunoglobulin1Inherited
Glucocorticoid receptor-like (DNA-binding domain)1Inherited
MHC antigen-recognition domain1Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)1Inherited
Cysteine-rich domain1Inherited
TNF-like1Inherited
RNI-like1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
Snake toxin-like1Inherited
TNF receptor-like1Inherited
DEATH domain1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 1Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 1Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 1Inherited
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 1Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 1Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 1Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 1Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 1Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 1Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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