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Phenotypic Abnormality (PA): Neurodevelopmental delay

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(140|161) (154|97|43)
+ + 2:   Abnormality of nervous system physiology [HP:0012638] <26>(102|116) (111|76|37)
+ 1:   Neurodevelopmental abnormality [HP:0012759] <5>(33|51) (38|22|10)
0:   Neurodevelopmental delay [HP:0012758] <4>(19|31) (21|9|2)
- 1:   Global developmental delay [HP:0001263] <4>(11|17) (11|4|0)
- 1:   Delayed speech and language development [HP:0000750] <3>(3|5) (4|1|0)
- 1:   Motor delay [HP:0001270] <2>(0|1) (1|0|0)
- 1:   Delayed social development [HP:0012434](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
Hect, E3 ligase catalytic domain0Direct
Helical domain of Sec23/240Direct
Lamin A/C globular tail domain0Direct
CCCH zinc finger0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
RuvA domain 2-like0Direct
PP2C-like0Direct
BRK domain-like0Direct
Ribonuclease PH domain 2-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
L-aspartase-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0006458Direct
SET domain0.004259Inherited
ARID-like0.02504Inherited
Bromodomain0.0991Inherited
Periplasmic binding protein-like I0.1434Inherited
HMG-box0.1878Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
Protein serine/threonine phosphatase0Direct
CCCH zinc finger0Direct
PP2C-like0Direct
Anticodon-binding domain0Direct
Glycosyl transferases group 10Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Histone lysine methyltransferases0Direct
Lamin A/C globular tail domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
BRK domain-like0Direct
Hect, E3 ligase catalytic domain0Direct
Ferredoxin domains from multidomain proteins0Direct
Zn-finger domain of Sec23/240Direct
L-aspartase/fumarase0Direct
Ribonuclease PH domain 1-like0Direct
CUT domain0Direct
Ribonuclease PH domain 2-like0Direct
N-acetyl transferase, NAT0Direct
beta-sandwich domain of Sec23/240Direct
Pyridoxal-dependent decarboxylase0Direct
SWIRM domain0Direct
Trunk domain of Sec23/240Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0006162Direct
ARID domain0.01503Inherited
L-arabinose binding protein-like0.02201Inherited
Bromodomain0.07004Inherited
MIR domain0.08882Inherited
PHD domain0.09965Inherited
HMG-box0.14Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Hect, E3 ligase catalytic domain0Direct
Zn-finger domain of Sec23/240Direct
Helical domain of Sec23/240Direct
Ribonuclease PH domain 2-like0Direct
PP2C-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Lamin A/C globular tail domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
RuvA domain 2-like0Direct
L-aspartase-like0Direct
BRK domain-like0Direct
CCCH zinc finger0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0003432Direct
SET domain0.002618Inherited
ARM repeat0.004167Inherited
ARID-like0.01756Inherited
Bromodomain0.07843Inherited
MIR domain0.09748Inherited
Periplasmic binding protein-like I0.1173Inherited
HMG-box0.1569Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)