SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Neurodevelopmental abnormality

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ 1:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
0:   Neurodevelopmental abnormality [HP:0012759] <5>(34|50) (39|26|11)
- 1:   Intellectual disability [HP:0001249] <6>(10|11) (10|5|2)
- 1:   Neurodevelopmental delay [HP:0012758] <4>(16|28) (18|10|2)
- 1:   Specific learning disability [HP:0001328] <3>(1|3) (4|2|0)
- 1:   Developmental stagnation [HP:0007281] <1>(0|0) (0|0|0)
- 1:   Developmental regression [HP:0002376](0|3) (0|1|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ribonuclease PH domain 2-like0Direct
BRK domain-like0Direct
Methylglyoxal synthase-like0Direct
L27 domain0Direct
Putative DNA-binding domain0Direct
Zn-finger domain of Sec23/240Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
PP2C-like0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Lamin A/C globular tail domain0Direct
Restriction endonuclease-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Pseudouridine synthase0Direct
L-aspartase-like0Direct
CCCH zinc finger0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
JAB1/MPN domain0Direct
RuvA domain 2-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Hect, E3 ligase catalytic domain0Direct
Helical domain of Sec23/240Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
ADC-like0Direct
Arginase/deacetylase0Direct
Proton glutamate symport protein0Direct
GST C-terminal domain-like0.04739Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.05011Inherited
SET domain0.06174Inherited
Bromodomain0.06174Inherited
ARID-like0.07471Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.1143Inherited
RNA-binding domain, RBD0.6358Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
Ribonuclease PH domain 1-like0Direct
Ferredoxin domains from multidomain proteins0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
JAB1/MPN domain0Direct
Helical domain of Sec23/240Direct
Amylase, catalytic domain0Direct
beta-sandwich domain of Sec23/240Direct
Anticodon-binding domain0Direct
beta-glycanases0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
BRK domain-like0Direct
Proton glutamate symport protein0Direct
Trunk domain of Sec23/240Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Zn-finger domain of Sec23/240Direct
Glycosyl transferases group 10Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Histone lysine methyltransferases0Direct
IF2B-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
N-acetyl transferase, NAT0Direct
CCCH zinc finger0Direct
L27 domain0Direct
Histone deacetylase, HDAC0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
PWWP domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
CUT domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Exostosin0Direct
PP2C-like0Direct
Ribonuclease PH domain 2-like0Direct
Lamin A/C globular tail domain0Direct
L-aspartase/fumarase0Direct
Hect, E3 ligase catalytic domain0Direct
SWIRM domain0Direct
Protein serine/threonine phosphatase0Direct
Extended AAA-ATPase domain0.000409Direct
PHD domain0.01188Inherited
HMG-box0.01963Inherited
Bromodomain0.04068Inherited
ARID domain0.05306Inherited
DNA gyrase/MutL, second domain0.0872Inherited
DNA gyrase/MutL, N-terminal domain0.0872Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.1028Inherited
L-arabinose binding protein-like0.1137Inherited
Nicotinic receptor ligand binding domain-like0.4849Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4849Inherited
Canonical RBD0.721Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
BRK domain-like0Direct
JAB1/MPN domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Helical domain of Sec23/240Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
ADC-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
L-aspartase-like0Direct
Restriction endonuclease-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Lamin A/C globular tail domain0Direct
Arginase/deacetylase0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
PP2C-like0Direct
Putative DNA-binding domain0Direct
Zn-finger domain of Sec23/240Direct
Methylglyoxal synthase-like0Direct
Ribonuclease PH domain 2-like0Direct
CCCH zinc finger0Direct
L27 domain0Direct
RuvA domain 2-like0Direct
Hect, E3 ligase catalytic domain0Direct
Pseudouridine synthase0Direct
Proton glutamate symport protein0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
HMG-box0.02364Inherited
GST C-terminal domain-like0.03509Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.03733Inherited
Bromodomain0.04684Inherited
SET domain0.04684Inherited
ARID-like0.05765Inherited
Periplasmic binding protein-like I0.0731Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.09108Inherited
"Winged helix" DNA-binding domain0.4232Inherited
Nicotinic receptor ligand binding domain-like0.5206Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.5206Inherited
RNA-binding domain, RBD0.5962Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00008776Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.09304Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.5206Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.8546Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)