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Phenotypic Abnormality (PA): Abnormality of the digestive system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the digestive system [HP:0025031] <6>(59|66) (66|38|20)
- 1:   Abnormality of abdomen morphology [HP:0001438] <7>(6|8) (8|2|1)
- 1:   Abnormality of the abdominal organs [HP:0002012] <6>(27|24) (31|12|2)
- 1:   Abnormality of digestive system physiology [HP:0025032] <5>(22|23) (26|11|0)
- 1:   Abnormality of the abdominal wall [HP:0004298] <5>(3|4) (3|5|7)
- 1:   Abnormality of the gastrointestinal tract [HP:0011024] <3>(18|22) (23|10|4)
- 1:   Abnormality of digestive system morphology [HP:0025033] <2>(11|15) (15|6|4)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Actin depolymerizing proteins0Direct
Zn-finger domain of Sec23/240Direct
Lamin A/C globular tail domain0Direct
dsRNA-binding domain-like0Direct
Glycosyl hydrolase domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Smc hinge domain0Direct
Restriction endonuclease-like0Direct
LuxS/MPP-like metallohydrolase0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
Notch domain0Direct
BPTI-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Galactose mutarotase-like0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
PA domain0Direct
Plakin repeat0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
ADC-like0Direct
Actin-like ATPase domain0.001127Inherited
(Trans)glycosidases0.002191Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00859Inherited
Acyl-CoA dehydrogenase NM domain-like0.04758Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.04758Inherited
RNI-like0.05284Inherited
Ribosomal protein S5 domain 2-like0.05396Inherited
Adenine nucleotide alpha hydrolases-like0.0541Inherited
DNA/RNA polymerases0.0541Inherited
ValRS/IleRS/LeuRS editing domain0.0835Inherited
Globin-like0.0835Inherited
MHC antigen-recognition domain0.09986Inherited
Integrin domains0.09986Inherited
Protein kinase-like (PK-like)0.1201Inherited
GroEL equatorial domain-like0.128Inherited
CalX-like0.128Inherited
ABC transporter transmembrane region0.1341Inherited
Ran binding protein zinc finger-like0.1431Inherited
Nucleotidylyl transferase0.1706Inherited
Calcium-dependent phosphotriesterase0.1934Inherited
DNA repair protein MutS, domain III0.1934Inherited
"Winged helix" DNA-binding domain0.1967Inherited
DEATH domain0.2202Inherited
TNF receptor-like0.2302Inherited
BRCT domain0.2539Inherited
FnI-like domain0.3594Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.377Inherited
Snake toxin-like0.4093Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.4357Inherited
alpha/beta-Hydrolases0.4569Inherited
SpoIIaa-like0.5517Inherited
Fibrinogen C-terminal domain-like0.5938Inherited
Ankyrin repeat0.6149Inherited
SH3-domain0.6149Inherited
TPR-like0.745Inherited
WD40 repeat-like0.7779Inherited
L domain-like0.8691Inherited
Homeodomain-like0.9434Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9744Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Glycosyl transferases group 10Direct
MPP-like0Direct
DnaQ-like 3'-5' exonuclease0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Lamin A/C globular tail domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
DIX domain0Direct
Zn-finger domain of Sec23/240Direct
beta-glycanases0Direct
Smc hinge domain0Direct
Subtilases0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Fibrinogen coiled-coil and central regions0Direct
YicI catalytic domain-like0Direct
Proteasome subunits0Direct
Sec1/munc18-like (SM) proteins0Direct
N-acetyl transferase, NAT0Direct
FAD/NAD-linked reductases, N-terminal and central domains0Direct
P4 origin-binding domain-like0Direct
Putative glucosidase YicI, domain 30Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
DNA polymerase I0Direct
Small Kunitz-type inhibitors & BPTI-like toxins0Direct
Plakin repeat0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01086Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.01473Inherited
Actin/HSP700.02824Inherited
Histone lysine methyltransferases0.06083Inherited
28-residue LRR0.06083Inherited
Protein kinases, catalytic subunit0.06311Inherited
Extended AAA-ATPase domain0.06526Inherited
Ras-binding domain, RBD0.07181Inherited
ValRS/IleRS/LeuRS editing domain0.07181Inherited
Globins0.07181Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.08874Inherited
RecA protein-like (ATPase-domain)0.08874Inherited
Integrin domains0.08874Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.08874Inherited
MHC antigen-recognition domain0.08874Inherited
C1 set domains (antibody constant domain-like)0.09246Inherited
DNA gyrase/MutL, second domain0.1118Inherited
CalX-beta domain0.1118Inherited
Pyrin domain, PYD0.1118Inherited
DNA gyrase/MutL, N-terminal domain0.1118Inherited
Ran binding protein zinc finger-like0.1281Inherited
BCR-homology GTPase activation domain (BH-domain)0.1282Inherited
DNA repair protein MutS, domain III0.1729Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.1729Inherited
VWC domain0.1827Inherited
DEATH domain, DD0.2499Inherited
BC N-terminal domain-like0.2574Inherited
BC ATP-binding domain-like0.2574Inherited
ABC transporter transmembrane region0.2799Inherited
Laminin-type module0.3161Inherited
EGF-type module0.3181Inherited
SNARE fusion complex0.3589Inherited
Anti-sigma factor antagonist SpoIIaa0.3589Inherited
TNF receptor-like0.3595Inherited
Fibrinogen C-terminal domain-like0.5816Inherited
Ankyrin repeat0.6224Inherited
SH3-domain0.675Inherited
Homeodomain0.9696Inherited
Ngr ectodomain-like0.9797Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Glycosyl hydrolase domain0Direct
Notch domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
BPTI-like0Direct
Zn-finger domain of Sec23/240Direct
ADC-like0Direct
PA domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Plakin repeat0Direct
Smc hinge domain0Direct
Actin depolymerizing proteins0Direct
dsRNA-binding domain-like0Direct
LuxS/MPP-like metallohydrolase0Direct
Lamin A/C globular tail domain0Direct
Galactose mutarotase-like0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
Restriction endonuclease-like0Direct
Actin-like ATPase domain0.000621Direct
SH2 domain0.0008132Direct
(Trans)glycosidases0.001271Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.005597Inherited
beta-sandwich domain of Sec23/240.02512Inherited
Acyl-CoA dehydrogenase NM domain-like0.03529Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.03529Inherited
RNI-like0.03955Inherited
Ribosomal protein S5 domain 2-like0.04051Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.04062Inherited
DNA/RNA polymerases0.04062Inherited
Adenine nucleotide alpha hydrolases-like0.04062Inherited
ValRS/IleRS/LeuRS editing domain0.06519Inherited
Globin-like0.06519Inherited
MHC antigen-recognition domain0.0791Inherited
Integrin domains0.0791Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.08122Inherited
Protein kinase-like (PK-like)0.09643Inherited
GroEL equatorial domain-like0.1034Inherited
CalX-like0.1034Inherited
ABC transporter transmembrane region0.109Inherited
Ran binding protein zinc finger-like0.1169Inherited
Nucleotidylyl transferase0.1414Inherited
DNA repair protein MutS, domain III0.1619Inherited
Calcium-dependent phosphotriesterase0.1619Inherited
"Winged helix" DNA-binding domain0.165Inherited
DEATH domain0.1868Inherited
TNF receptor-like0.196Inherited
SET domain0.2015Inherited
E set domains0.203Inherited
BRCT domain0.218Inherited
FnI-like domain0.3188Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.336Inherited
SNARE fusion complex0.3414Inherited
Snake toxin-like0.3675Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.3934Inherited
alpha/beta-Hydrolases0.4144Inherited
SpoIIaa-like0.5088Inherited
Fibrinogen C-terminal domain-like0.5521Inherited
Ankyrin repeat0.5739Inherited
SH3-domain0.5739Inherited
TPR-like0.7087Inherited
WD40 repeat-like0.7432Inherited
L domain-like0.8385Inherited
Homeodomain-like0.9172Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9514Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.001888Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.03529Inherited
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0.06519Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0791Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.1034Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1034Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.109Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1599Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.1619Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.1619Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.1619Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1619Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2411Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2607Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.3934Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3939Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.5521Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.6571Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1619Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1619Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2582Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.8088Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8706Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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