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Phenotypic Abnormality (PA): Abnormality of digestive system physiology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the digestive system [HP:0025031] <6>(67|77) (77|47|25)
0:   Abnormality of digestive system physiology [HP:0025032] <5>(29|32) (37|14|1)
- 1:   Abdominal symptom [HP:0011458] <12>(17|20) (21|8|1)
- 1:   Functional abnormality of the gastrointestinal tract [HP:0012719] <11>(10|11) (14|2|0)
- 1:   Abnormal large intestine physiology [HP:0012700] <4>(0|0) (0|0|0)
- 1:   Abnormality of hepatobiliary system physiology [HP:0025155] <3>(2|2) (2|2|0)
- 1:   Dependency on intravenous nutrition [HP:0025156](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Tricorn protease domain 20Direct
DHS-like NAD/FAD-binding domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
ADC-like0Direct
Plakin repeat0Direct
SAND domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Ribonuclease PH domain 2-like0Direct
BPTI-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0007324Direct
Adenine nucleotide alpha hydrolases-like0.01354Inherited
ValRS/IleRS/LeuRS editing domain0.02651Inherited
SET domain0.08964Inherited
4Fe-4S ferredoxins0.09252Inherited
MHC antigen-recognition domain0.0984Inherited
RNI-like0.11Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1352Inherited
Acyl-CoA dehydrogenase NM domain-like0.1352Inherited
beta-sandwich domain of Sec23/240.2475Inherited
DEATH domain0.2555Inherited
SpoIIaa-like0.3269Inherited
Immunoglobulin0.3604Inherited
Complement control module/SCR domain0.3925Inherited
Integrin domains0.5591Inherited
Ran binding protein zinc finger-like0.5591Inherited
L domain-like0.7267Inherited
Actin-like ATPase domain0.745Inherited
Intermediate filament protein, coiled coil region0.7825Inherited
Homeodomain-like0.8203Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Serum paraoxonase/arylesterase 1, PON10Direct
P4 origin-binding domain-like0Direct
Ribonuclease PH domain 1-like0Direct
Plakin repeat0Direct
Small Kunitz-type inhibitors & BPTI-like toxins0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribonuclease PH domain 2-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.001015Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.002194Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.002194Inherited
Histone lysine methyltransferases0.009904Inherited
ValRS/IleRS/LeuRS editing domain0.01987Inherited
DNA gyrase/MutL, second domain0.03929Inherited
DNA gyrase/MutL, N-terminal domain0.03929Inherited
C1 set domains (antibody constant domain-like)0.05777Inherited
MHC antigen-recognition domain0.08367Inherited
Nitrogenase iron protein-like0.1063Inherited
28-residue LRR0.1752Inherited
Actin/HSP700.1752Inherited
SNARE fusion complex0.1802Inherited
Anti-sigma factor antagonist SpoIIaa0.1802Inherited
Eukaryotic proteases0.3479Inherited
Complement control module/SCR domain0.3601Inherited
BC N-terminal domain-like0.418Inherited
BC ATP-binding domain-like0.418Inherited
Pyrin domain, PYD0.418Inherited
Integrin domains0.5267Inherited
Ran binding protein zinc finger-like0.5267Inherited
Transforming growth factor (TGF)-beta0.7734Inherited
Intermediate filament protein, coiled coil region0.7739Inherited
Ngr ectodomain-like0.83Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
DHS-like NAD/FAD-binding domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
SAND domain-like0Direct
Ribonuclease PH domain 2-like0Direct
ADC-like0Direct
BPTI-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0003801Direct
Adenine nucleotide alpha hydrolases-like0.008935Inherited
ValRS/IleRS/LeuRS editing domain0.01839Inherited
SET domain0.06968Inherited
Calcium-dependent phosphotriesterase0.0721Inherited
4Fe-4S ferredoxins0.0721Inherited
MHC antigen-recognition domain0.07712Inherited
RNI-like0.08675Inherited
Acyl-CoA dehydrogenase NM domain-like0.1093Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1093Inherited
Class II aaRS and biotin synthetases0.1191Inherited
SNARE fusion complex0.1723Inherited
beta-sandwich domain of Sec23/240.211Inherited
DEATH domain0.2182Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2684Inherited
SpoIIaa-like0.2858Inherited
Immunoglobulin0.3183Inherited
Complement control module/SCR domain0.3491Inherited
Integrin domains0.5156Inherited
Ran binding protein zinc finger-like0.5156Inherited
4-helical cytokines0.5156Inherited
Snake toxin-like0.5156Inherited
Trypsin-like serine proteases0.6485Inherited
L domain-like0.6884Inherited
Actin-like ATPase domain0.7075Inherited
Intermediate filament protein, coiled coil region0.7463Inherited
Homeodomain-like0.7862Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.7945Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0.01839Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.03662Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03662Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.07712Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1093Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3999Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.5156Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.6223Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1696Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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