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Phenotypic Abnormality (PA): Abnormality of cardiovascular system morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the cardiovascular system [HP:0001626] <5>(58|73) (67|39|27)
0:   Abnormality of cardiovascular system morphology [HP:0030680] <3>(26|40) (32|17|20)
- 1:   Abnormal heart morphology [HP:0001627] <16>(19|32) (22|14|20)
- 1:   Abnormal vascular morphology [HP:0025015] <12>(11|17) (17|11|10)
- 1:   Cardiovascular calcification [HP:0011915] <3>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
BRK domain-like0Direct
RmlC-like cupins0Direct
Notch domain0Direct
TB module/8-cys domain0Direct
(Trans)glycosidases0.03456Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.06246Inherited
Protein kinase-like (PK-like)0.1403Inherited
Tropomyosin0.166Inherited
FnI-like domain0.2199Inherited
MIR domain0.2236Inherited
Actin-like ATPase domain0.2496Inherited
Ribosomal protein S5 domain 2-like0.269Inherited
Snake toxin-like0.2788Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2959Inherited
SMAD MH1 domain0.3015Inherited
Spectrin repeat0.3047Inherited
MHC antigen-recognition domain0.352Inherited
TPR-like0.4469Inherited
FAD/NAD(P)-binding domain0.5952Inherited
SMAD/FHA domain0.6Inherited
Nicotinic receptor ligand binding domain-like0.657Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.657Inherited
4-helical cytokines0.7664Inherited
DEATH domain0.8583Inherited
TNF receptor-like0.9734Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
TB module/8-cys domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
BRK domain-like0Direct
Smc hinge domain0Direct
ZZ domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Actin/HSP700.0008966Direct
Histone lysine methyltransferases0.01193Inherited
DNA gyrase/MutL, second domain0.01542Inherited
Amylase, catalytic domain0.01542Inherited
DNA gyrase/MutL, N-terminal domain0.01542Inherited
Double-stranded RNA-binding domain (dsRBD)0.03698Inherited
Extracellular domain of cell surface receptors0.04747Inherited
Growth factor receptor domain0.05976Inherited
Protein kinases, catalytic subunit0.08659Inherited
VWC domain0.09448Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.09499Inherited
RecA protein-like (ATPase-domain)0.09499Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.09499Inherited
LIM domain0.09499Inherited
Erythroid transcription factor GATA-10.09499Inherited
Transforming growth factor (TGF)-beta0.1044Inherited
Tropomyosin0.1332Inherited
Myosin rod fragments0.135Inherited
T-box0.1379Inherited
EGF-type module0.144Inherited
DEATH domain, DD0.1805Inherited
MIR domain0.1861Inherited
Tetratricopeptide repeat (TPR)0.2207Inherited
PHD domain0.2207Inherited
Spectrin repeat0.2583Inherited
SMAD domain0.2594Inherited
beta-glycanases0.2594Inherited
SMAD MH1 domain0.2594Inherited
MHC antigen-recognition domain0.304Inherited
ABC transporter ATPase domain-like0.4947Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6243Inherited
Nicotinic receptor ligand binding domain-like0.6243Inherited
C1 set domains (antibody constant domain-like)0.6394Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Notch domain0Direct
TB module/8-cys domain0Direct
Smc hinge domain0Direct
BRK domain-like0Direct
RmlC-like cupins0Direct
Acyl-CoA N-acyltransferases (Nat)0.0154Inherited
(Trans)glycosidases0.02497Inherited
p53-like transcription factors0.02797Inherited
Restriction endonuclease-like0.03672Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.04749Inherited
Protein kinase-like (PK-like)0.1144Inherited
Myosin rod fragments0.1373Inherited
Tropomyosin0.1373Inherited
FnI-like domain0.1865Inherited
MIR domain0.19Inherited
Actin-like ATPase domain0.2139Inherited
Ribosomal protein S5 domain 2-like0.2325Inherited
Snake toxin-like0.2415Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2582Inherited
SMAD MH1 domain0.2636Inherited
Spectrin repeat0.2667Inherited
MHC antigen-recognition domain0.3116Inherited
TPR-like0.4045Inherited
RNI-like0.4895Inherited
FAD/NAD(P)-binding domain0.5535Inherited
SMAD/FHA domain0.5586Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6175Inherited
Nicotinic receptor ligand binding domain-like0.6175Inherited
EF-hand0.6299Inherited
4-helical cytokines0.731Inherited
DEATH domain0.8271Inherited
TNF receptor-like0.9504Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0006879Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.0154Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.04593Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.04682Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1093Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1431Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.1431Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3116Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4895Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.6175Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.9489Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.002329Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.00984Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04887Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1431Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3984Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3984Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.4059Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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