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Phenotypic Abnormality (PA): Abnormality of forebrain morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Phenotypic abnormality [HP:0000118] <25>
+ + + + 4:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ + + 3:   Abnormality of nervous system morphology [HP:0012639] <5>(69|97) (79|52|16)
+ + 2:   Morphological abnormality of the central nervous system [HP:0002011] <17>(60|85) (69|44|16)
+ 1:   Abnormality of brain morphology [HP:0012443] <13>(43|63) (53|34|15)
0:   Abnormality of forebrain morphology [HP:0100547] <6>(26|32) (30|18|5)
- 1:   Abnormality of the cerebrum [HP:0002060] <16>(25|31) (29|18|5)
- 1:   Abnormality of the diencephalon [HP:0010662] <3>(0|0) (0|0|0)
- 1:   Abnormal morphology of the limbic system [HP:0007343] <2>(0|0) (0|0|0)
- 1:   Abnormal morphology of the olfactory bulb [HP:0040327] <2>(0|0) (0|0|0)
- 1:   Abnormality of olfactory lobe morphology [HP:0025057] <2>(0|0) (0|0|0)
- 1:   Aplasia of the olfactory tract [HP:0020128](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
ADC-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Restriction endonuclease-like0Direct
Pseudouridine synthase0Direct
Smc hinge domain0Direct
4Fe-4S ferredoxins0Direct
SAND domain-like0Direct
Ribonuclease PH domain 2-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Class II aaRS and biotin synthetases0.01488Inherited
WD40 repeat-like0.01608Inherited
ARID-like0.0164Inherited
NagB/RpiA/CoA transferase-like0.04937Inherited
Adenine nucleotide alpha hydrolases-like0.04937Inherited
Tubulin nucleotide-binding domain-like0.06181Inherited
Actin-like ATPase domain0.09237Inherited
Tubulin C-terminal domain-like0.09597Inherited
Nucleotidylyl transferase0.153Inherited
Periplasmic binding protein-like II0.2356Inherited
Nucleotide-diphospho-sugar transferases0.2874Inherited
Ribonuclease H-like0.4741Inherited
Homeodomain-like0.5637Inherited
ARM repeat0.6682Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin domains from multidomain proteins0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
N-acetyl transferase, NAT0Direct
Clathrin adaptor core protein0Direct
SWIRM domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Smc hinge domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
L-aspartase/fumarase0Direct
Ribonuclease PH domain 1-like0Direct
Exostosin0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Ribonuclease PH domain 2-like0Direct
IF2B-like0Direct
Histone lysine methyltransferases0.0002651Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0003096Direct
ARID domain0.009708Inherited
G proteins0.01066Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.01338Inherited
Bromodomain0.02336Inherited
Tubulin, GTPase domain0.03996Inherited
Ypt/Rab-GAP domain of gyp1p0.04912Inherited
Tubulin, C-terminal domain0.06644Inherited
PHD domain0.1087Inherited
Elongation factors0.1503Inherited
Phosphate binding protein-like0.1861Inherited
Crotonase-like0.2113Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2819Inherited
Transducin (alpha subunit), insertion domain0.3574Inherited
PDZ domain0.4357Inherited
Homeodomain0.5925Inherited
T-box0.6115Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Acyl-CoA N-acyltransferases (Nat)0Direct
Smc hinge domain0Direct
Pseudouridine synthase0Direct
Restriction endonuclease-like0Direct
SAND domain-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
4Fe-4S ferredoxins0Direct
Ribonuclease PH domain 2-like0Direct
ADC-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.001874Inherited
Class II aaRS and biotin synthetases0.009884Inherited
WD40 repeat-like0.01074Inherited
ARID-like0.01098Inherited
Bromodomain0.02794Inherited
Adenine nucleotide alpha hydrolases-like0.03634Inherited
NagB/RpiA/CoA transferase-like0.03634Inherited
Tubulin nucleotide-binding domain-like0.04652Inherited
Actin-like ATPase domain0.072Inherited
Tubulin C-terminal domain-like0.0751Inherited
Nucleotidylyl transferase0.1251Inherited
Periplasmic binding protein-like II0.1999Inherited
Nucleotide-diphospho-sugar transferases0.2483Inherited
PDZ domain-like0.2583Inherited
Transducin (alpha subunit), insertion domain0.3775Inherited
Ribonuclease H-like0.4303Inherited
Homeodomain-like0.5203Inherited
ARM repeat0.6281Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.05242Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0751Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0751Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.1306Inherited
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.1335Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.164Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.164Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3775Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7971Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6398Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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