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Mammalian Phenotype (MP): liver/biliary system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   liver/biliary system phenotype [MP:0005370] <2>(37|39) (41|19|10)
- 1:   abnormal hepatobiliary system morphology [MP:0002138] <6>(25|32) (28|15|5)
- 1:   abnormal hepatobiliary system physiology [MP:0002139] <4>(16|14) (16|10|7)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Hairpin loop containing domain-like0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Nuclear receptor ligand-binding domain0.000002972Direct
(Trans)glycosidases0.00002793Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0005153Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0006157Direct
Acyl-CoA dehydrogenase NM domain-like0.0006157Direct
p53-like transcription factors0.0008545Direct
Flavoproteins0.0008933Direct
Transcription factor STAT-4 N-domain0.0008933Direct
STAT0.0008933Direct
Families 57/38 glycoside transferase middle domain0.00101Inherited
4-helical cytokines0.00153Inherited
HMA, heavy metal-associated domain0.00469Inherited
DHS-like NAD/FAD-binding domain0.005085Inherited
Alpha-macroglobulin receptor domain0.008733Inherited
Terpenoid cyclases/Protein prenyltransferases0.009212Inherited
Kringle-like0.01464Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01638Inherited
Bet v1-like0.01797Inherited
SH2 domain0.02204Inherited
TNF receptor-like0.02514Inherited
DEATH domain0.0334Inherited
ABC transporter transmembrane region0.04051Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.05641Inherited
Riboflavin synthase domain-like0.05641Inherited
Leucine zipper domain0.06506Inherited
Cyclin-like0.08515Inherited
YWTD domain0.1186Inherited
C-type lectin-like0.1244Inherited
WW domain0.1292Inherited
lambda repressor-like DNA-binding domains0.1298Inherited
A DNA-binding domain in eukaryotic transcription factors0.1691Inherited
Trypsin-like serine proteases0.381Inherited
Family A G protein-coupled receptor-like0.8109Inherited
Homeodomain-like0.8144Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Nuclear receptor ligand-binding domain0.000002479Direct
Nuclear receptor0.000004821Direct
STAT0.0006037Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0006037Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0006037Direct
Sir2 family of transcriptional regulators0.0006037Direct
Transcription factor STAT-4 N-domain0.0006037Direct
STAT DNA-binding domain0.0006037Direct
alpha-mannosidase, domain 20.0006715Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0006715Direct
alpha-mannosidase0.0006715Direct
NADPH-cytochrome p450 reductase-like0.0006715Direct
Rel/Dorsal transcription factors, DNA-binding domain0.001015Inherited
HMA, heavy metal-associated domain0.003299Inherited
Fatty acid binding protein-like0.003428Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.006309Inherited
Complement components0.00645Inherited
Alpha-macroglobulin receptor domain0.00645Inherited
DEATH domain, DD0.006776Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.009807Inherited
Erythroid transcription factor GATA-10.01254Inherited
ABC transporter ATPase domain-like0.01421Inherited
TNF receptor-like0.02009Inherited
SH2 domain0.02096Inherited
p120GAP domain-like0.03219Inherited
Kringle modules0.03545Inherited
Forkhead DNA-binding domain0.03711Inherited
ABC transporter transmembrane region0.04542Inherited
Leucine zipper domain0.0585Inherited
YWTD domain0.1032Inherited
WW domain0.1162Inherited
A DNA-binding domain in eukaryotic transcription factors0.1506Inherited
Eukaryotic proteases0.4016Inherited
Chaperone J-domain0.4121Inherited
Rhodopsin-like0.6502Inherited
Homeodomain0.9617Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Hairpin loop containing domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Nuclear receptor ligand-binding domain0.000001253Direct
(Trans)glycosidases0.00001279Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0002725Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000327Direct
Acyl-CoA dehydrogenase NM domain-like0.000327Direct
p53-like transcription factors0.0004626Direct
Transcription factor STAT-4 N-domain0.0004841Direct
STAT0.0004841Direct
Flavoproteins0.0004841Direct
Families 57/38 glycoside transferase middle domain0.0005515Direct
Protein kinase-like (PK-like)0.0005756Direct
4-helical cytokines0.0008574Direct
HMA, heavy metal-associated domain0.002797Inherited
DHS-like NAD/FAD-binding domain0.003048Inherited
Alpha-macroglobulin receptor domain0.005405Inherited
Terpenoid cyclases/Protein prenyltransferases0.005723Inherited
Kringle-like0.009399Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01061Inherited
Bet v1-like0.01172Inherited
SH2 domain0.01459Inherited
TNF receptor-like0.01683Inherited
DEATH domain0.02288Inherited
ABC transporter transmembrane region0.02818Inherited
Riboflavin synthase domain-like0.04033Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.04033Inherited
Leucine zipper domain0.04724Inherited
Cyclin-like0.06324Inherited
EGF/Laminin0.06556Inherited
Insulin-like0.07414Inherited
YWTD domain0.09143Inherited
C-type lectin-like0.09632Inherited
WW domain0.1004Inherited
lambda repressor-like DNA-binding domains0.101Inherited
A DNA-binding domain in eukaryotic transcription factors0.1353Inherited
Trypsin-like serine proteases0.3349Inherited
Chaperone J-domain0.3798Inherited
Family A G protein-coupled receptor-like0.7767Inherited
Homeodomain-like0.7805Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00001279Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.000327Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0004841Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0004841Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0004841Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0.0005515Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0008022Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00137Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.004232Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01809Inherited
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0.01957Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02818Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.07185Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.07207Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.2532Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0004841Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0004841Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.002696Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.009158Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01957Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.01957Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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