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Mammalian Phenotype (MP): endocrine/exocrine gland phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   endocrine/exocrine gland phenotype [MP:0005379] <2>(50|79) (55|35|12)
- 1:   abnormal gland morphology [MP:0002163] <8>(43|69) (50|30|11)
- 1:   abnormal gland physiology [MP:0002164] <4>(9|19) (11|11|5)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog/intein (Hint) domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
p53 tetramerization domain0Direct
Hedgehog/DD-peptidase0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain-like0.00000003184Direct
Nuclear receptor ligand-binding domain0.000003241Direct
Protein kinase-like (PK-like)0.000007838Direct
p53-like transcription factors0.00003847Direct
Insulin-like0.0001001Direct
SMAD MH1 domain0.0003227Direct
SH2 domain0.0007516Direct
"Winged helix" DNA-binding domain0.0007597Direct
E2F-DP heterodimerization region0.00101Inherited
Transcription factor STAT-4 N-domain0.00101Inherited
STAT0.00101Inherited
Bcl-2 inhibitors of programmed cell death0.001547Inherited
Tudor/PWWP/MBT0.004207Inherited
HLH, helix-loop-helix DNA-binding domain0.004208Inherited
Caspase-like0.004211Inherited
PAZ domain0.004238Inherited
Cystine-knot cytokines0.004926Inherited
4-helical cytokines0.006464Inherited
HMG-box0.008823Inherited
Notch domain0.008901Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.0105Inherited
The spindle assembly checkpoint protein mad20.02474Inherited
IP3 receptor type 1 binding core, domain 20.02767Inherited
Growth factor receptor domain0.03285Inherited
Nucleic acid-binding proteins0.04848Inherited
TNF receptor-like0.05707Inherited
MIR domain0.09467Inherited
Band 7/SPFH domain0.1788Inherited
Cysteine-rich domain0.2056Inherited
E set domains0.2068Inherited
LDL receptor-like module0.2119Inherited
beta-beta-alpha zinc fingers0.2431Inherited
SMAD/FHA domain0.2829Inherited
Thyroglobulin type-1 domain0.2848Inherited
CCCH zinc finger0.2983Inherited
TNF-like0.2995Inherited
BRCT domain0.3395Inherited
EGF/Laminin0.3474Inherited
Rhodanese/Cell cycle control phosphatase0.3852Inherited
Family A G protein-coupled receptor-like0.4275Inherited
WW domain0.4356Inherited
RING/U-box0.4627Inherited
Intermediate filament protein, coiled coil region0.8665Inherited
Immunoglobulin0.9446Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Retinoblastoma tumor suppressor domains0Direct
Pointed domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog (development protein), N-terminal signaling domain0Direct
RUNT domain0Direct
p53 DNA-binding domain-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
p53 tetramerization domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
E2F dimerization segment0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Homeodomain0.0000003733Direct
Nuclear receptor ligand-binding domain0.000003553Direct
Nuclear receptor0.00001796Direct
Insulin-like0.00007117Direct
Paired domain0.00007117Direct
Protein kinases, catalytic subunit0.0001074Direct
SMAD domain0.0002323Direct
SMAD MH1 domain0.0002323Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000411Direct
STAT0.0007333Direct
L domain0.0007333Direct
CUT domain0.0007333Direct
Transcription factor STAT-4 N-domain0.0007333Direct
STAT DNA-binding domain0.0007333Direct
SH2 domain0.0009206Direct
Bcl-2 inhibitors of programmed cell death0.001175Inherited
Caspase catalytic domain0.00136Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.00137Inherited
Growth factor receptor domain0.002746Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.003072Inherited
PAZ domain0.003279Inherited
Transforming growth factor (TGF)-beta0.004438Inherited
HLH, helix-loop-helix DNA-binding domain0.005027Inherited
Notch domain0.006779Inherited
Short-chain cytokines0.007064Inherited
HMG-box0.008489Inherited
Tudor domain0.008555Inherited
ets domain0.008647Inherited
Cell cycle transcription factor e2f-dp0.008856Inherited
TNF receptor-like0.01054Inherited
Forkhead DNA-binding domain0.01795Inherited
Extracellular domain of cell surface receptors0.01836Inherited
The spindle assembly checkpoint protein mad20.01952Inherited
DEATH domain, DD0.02016Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.021Inherited
DNA polymerase I0.02235Inherited
Ras-binding domain, RBD0.02331Inherited
Single strand DNA-binding domain, SSB0.04783Inherited
Cysteine-rich DNA binding domain, (DM domain)0.04783Inherited
Gonadodropin/Follitropin0.05465Inherited
Transducin (alpha subunit), insertion domain0.06022Inherited
EGF-type module0.06514Inherited
MIR domain0.08259Inherited
Long-chain cytokines0.1063Inherited
Linker histone H1/H50.1252Inherited
DnaQ-like 3'-5' exonuclease0.1353Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1747Inherited
Caspase recruitment domain, CARD0.1777Inherited
Papain-like0.178Inherited
LDL receptor-like module0.21Inherited
Thyroglobulin type-1 domain0.2733Inherited
CCCH zinc finger0.2839Inherited
TNF-like0.302Inherited
V set domains (antibody variable domain-like)0.311Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.4012Inherited
Cell cycle control phosphatase, catalytic domain0.4296Inherited
WW domain0.4358Inherited
Phosphotyrosine-binding domain (PTB)0.4601Inherited
FHA domain0.5744Inherited
Rhodopsin-like0.669Inherited
I set domains0.7348Inherited
Cytochrome P4500.7748Inherited
Intermediate filament protein, coiled coil region0.872Inherited
Pleckstrin-homology domain (PH domain)0.9154Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Hedgehog/intein (Hint) domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog/DD-peptidase0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Homeodomain-like0.00000001222Direct
Nuclear receptor ligand-binding domain0.000001371Direct
Protein kinase-like (PK-like)0.000003396Direct
p53-like transcription factors0.00001779Direct
Insulin-like0.00004833Direct
SMAD MH1 domain0.0001672Direct
SH2 domain0.0004038Direct
"Winged helix" DNA-binding domain0.0004081Direct
E2F-DP heterodimerization region0.0005517Direct
Transcription factor STAT-4 N-domain0.0005517Direct
STAT0.0005517Direct
Bcl-2 inhibitors of programmed cell death0.0008676Direct
Tudor/PWWP/MBT0.002488Inherited
HLH, helix-loop-helix DNA-binding domain0.002489Inherited
Caspase-like0.002492Inherited
PAZ domain0.002509Inherited
Cystine-knot cytokines0.002951Inherited
4-helical cytokines0.003941Inherited
HMG-box0.005461Inherited
Ribonuclease H-like0.005463Inherited
Notch domain0.005517Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006583Inherited
The spindle assembly checkpoint protein mad20.01654Inherited
IP3 receptor type 1 binding core, domain 20.01868Inherited
Growth factor receptor domain0.02249Inherited
Nucleic acid-binding proteins0.03416Inherited
Cysteine-rich DNA binding domain, (DM domain)0.04059Inherited
TNF receptor-like0.04087Inherited
Transducin (alpha subunit), insertion domain0.04914Inherited
MIR domain0.07103Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1196Inherited
Band 7/SPFH domain0.1441Inherited
Cysteine-rich domain0.1684Inherited
E set domains0.1695Inherited
LDL receptor-like module0.1742Inherited
beta-beta-alpha zinc fingers0.2034Inherited
SMAD/FHA domain0.2407Inherited
Thyroglobulin type-1 domain0.2424Inherited
CCCH zinc finger0.2551Inherited
TNF-like0.2563Inherited
BRCT domain0.2945Inherited
EGF/Laminin0.3021Inherited
Rhodanese/Cell cycle control phosphatase0.3389Inherited
Family A G protein-coupled receptor-like0.3808Inherited
WW domain0.3882Inherited
RING/U-box0.415Inherited
Cytochrome P4500.7309Inherited
Intermediate filament protein, coiled coil region0.8368Inherited
Immunoglobulin0.9226Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001817Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0002906Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.0003639Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0005517Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0005517Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0005517Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0005517Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0005517Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0005517Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.001766Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.002509Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.003566Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01002Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.01654Inherited
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.01868Inherited
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.01868Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01881Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03313Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.03313Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03322Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.043Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.04422Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.04764Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.05831Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.09114Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.09114Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1635Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.2945Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3478Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6539Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9013Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0005517Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0005517Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0005517Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.005269Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01709Inherited
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.01868Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02099Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.07123Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1066Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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