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Mammalian Phenotype (MP): embryo phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   embryo phenotype [MP:0005380] <7>(40|54) (46|28|19)
- 1:   abnormal extraembryonic tissue morphology [MP:0002086] <17>(13|18) (16|4|3)
- 1:   abnormal extraembryonic tissue physiology [MP:0004264] <10>(1|3) (2|2|1)
- 1:   abnormal embryonic tissue physiology [MP:0008932] <8>(1|3) (1|2|2)
- 1:   abnormal embryo development [MP:0001672] <5>(9|15) (11|11|5)
- 1:   abnormal embryo morphology [MP:0014134] <4>(23|31) (26|14|12)
- 1:   abnormal visceral endoderm morphology [MP:0011186] <3>(1|2) (1|0|0)
- 1:   abnormal visceral endoderm physiology [MP:0012028] <1>(1|1) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain-like0.000000000005681Direct
p53-like transcription factors0.000001864Direct
"Winged helix" DNA-binding domain0.000006602Direct
SMAD MH1 domain0.00006427Direct
Protein kinase-like (PK-like)0.00008009Direct
Bromodomain0.00009923Direct
Growth factor receptor domain0.0001973Direct
BRCT domain0.0003233Direct
HLH, helix-loop-helix DNA-binding domain0.0004401Direct
HMG-box0.0006527Direct
Frizzled cysteine-rich domain0.0006924Direct
SET domain0.0008792Direct
WD40 repeat-like0.001577Inherited
Nucleic acid-binding proteins0.002831Inherited
Notch domain0.003572Inherited
Cystine-knot cytokines0.005305Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006074Inherited
Cullin repeat-like0.01206Inherited
HCP-like0.0262Inherited
Cullin homology domain0.0262Inherited
SMAD/FHA domain0.02697Inherited
Nuclear receptor ligand-binding domain0.03039Inherited
Cyclin-like0.03463Inherited
DNA clamp0.03478Inherited
Snake toxin-like0.0389Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.06627Inherited
4-helical cytokines0.08463Inherited
Terpenoid cyclases/Protein prenyltransferases0.1021Inherited
Alpha-macroglobulin receptor domain0.1049Inherited
Integrin beta tail domain0.1049Inherited
Histone-fold0.1612Inherited
Ubiquitin-like0.2526Inherited
SAM/Pointed domain0.2738Inherited
Cytokine0.2768Inherited
TIMP-like0.5485Inherited
WW domain0.6509Inherited
Ankyrin repeat0.7209Inherited
PDZ domain-like0.7766Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
DNA ligase0Direct
p53 tetramerization domain0Direct
Homeodomain0.00000001133Direct
Histone lysine methyltransferases0.000008204Direct
T-box0.00001349Direct
SMAD domain0.00003873Direct
SMAD MH1 domain0.00003873Direct
Growth factor receptor domain0.00005835Direct
Bromodomain0.0000677Direct
HLH, helix-loop-helix DNA-binding domain0.0003688Direct
Frizzled cysteine-rich domain0.0004751Direct
HMG-box0.0004794Direct
DIX domain0.000632Direct
Extracellular domain of cell surface receptors0.0007245Direct
Protein kinases, catalytic subunit0.001049Inherited
Forkhead DNA-binding domain0.001537Inherited
Transforming growth factor (TGF)-beta0.002152Inherited
Paired domain0.002308Inherited
Notch domain0.002411Inherited
L domain0.002685Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.00522Inherited
Erythroid transcription factor GATA-10.007015Inherited
Formate/glycerate dehydrogenases, substrate-binding domain0.008861Inherited
Tetrahydrofolate dehydrogenase/cyclohydrolase0.008861Inherited
C5 cytosine-specific DNA methylase, DCM0.008861Inherited
Cullin repeat0.008861Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.01151Inherited
Nuclear receptor0.01722Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.01985Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.01985Inherited
Pointed domain0.01985Inherited
Cullin homology domain0.01985Inherited
Nuclear receptor ligand-binding domain0.02529Inherited
SCF ubiquitin ligase complex WHB domain0.02637Inherited
Integrin beta EGF-like domains0.03616Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.03616Inherited
Formate/glycerate dehydrogenases, NAD-domain0.05276Inherited
Linker histone H1/H50.05796Inherited
Cell cycle transcription factor e2f-dp0.05796Inherited
Ras-binding domain, RBD0.07201Inherited
Complement components0.08677Inherited
Alpha-macroglobulin receptor domain0.08677Inherited
Integrin beta tail domain0.08677Inherited
DEP domain0.116Inherited
Fibroblast growth factors (FGF)0.1227Inherited
ZZ domain0.1265Inherited
SAM (sterile alpha motif) domain0.4535Inherited
PDZ domain0.6077Inherited
WW domain0.6324Inherited
Ankyrin repeat0.7065Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain-like0.000000000002051Direct
p53-like transcription factors0.0000007679Direct
"Winged helix" DNA-binding domain0.000002836Direct
SMAD MH1 domain0.00003039Direct
Protein kinase-like (PK-like)0.00003827Direct
Bromodomain0.00004787Direct
Growth factor receptor domain0.00009962Direct
BRCT domain0.0001676Direct
HLH, helix-loop-helix DNA-binding domain0.000231Direct
HMG-box0.0003486Direct
Frizzled cysteine-rich domain0.0003699Direct
SET domain0.0004758Direct
beta-beta-alpha zinc fingers0.0005572Direct
WD40 repeat-like0.0008847Direct
Nucleic acid-binding proteins0.001638Inherited
Notch domain0.002093Inherited
Cystine-knot cytokines0.003192Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.003678Inherited
Cullin repeat-like0.007642Inherited
Cullin homology domain0.01759Inherited
HCP-like0.01759Inherited
Integrin domains0.018Inherited
SMAD/FHA domain0.01815Inherited
Nuclear receptor ligand-binding domain0.0207Inherited
Cyclin-like0.0238Inherited
DNA clamp0.02392Inherited
FYVE/PHD zinc finger0.02667Inherited
Snake toxin-like0.02693Inherited
FnI-like domain0.04432Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.04819Inherited
4-helical cytokines0.06284Inherited
Terpenoid cyclases/Protein prenyltransferases0.07732Inherited
Alpha-macroglobulin receptor domain0.07964Inherited
Integrin beta tail domain0.07964Inherited
Histone-fold0.1285Inherited
Ubiquitin-like0.2122Inherited
SAM/Pointed domain0.2321Inherited
Cytokine0.2349Inherited
GTPase activation domain, GAP0.3752Inherited
TIMP-like0.5017Inherited
WW domain0.6075Inherited
Ankyrin repeat0.6812Inherited
PDZ domain-like0.74Inherited
PH domain-like0.985Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001463Direct
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.0004034Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.002288Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.002288Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.002288Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.004428Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.005526Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.006765Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.007642Inherited
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.007844Inherited
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.007844Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01759Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01759Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.02392Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.02392Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.04819Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.04819Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.07964Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.09775Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1324Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.1746Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3404Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3662Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.709Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.000535Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.002093Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.002288Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.007642Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.007642Inherited
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.007844Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01759Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.07713Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.07964Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.07964Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1746Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2481Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3091Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.709Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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