SUPERFAMILY 1.75 HMM library and genome assignments server

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Mammalian Phenotype (MP): behavior/neurological phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   behavior/neurological phenotype [MP:0005386] <1>(38|60) (42|40|24)
- 1:   abnormal behavior [MP:0004924] <19>(37|55) (41|37|22)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
IP3 receptor type 1 binding core, domain 20Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Metallothionein0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
p53 tetramerization domain0Direct
C-terminal domain of PLC-beta0Direct
SRF-like0Direct
Family A G protein-coupled receptor-like0.00000001228Direct
Nicotinic receptor ligand binding domain-like0.000009771Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000009771Direct
Nuclear receptor ligand-binding domain0.00004065Direct
Periplasmic binding protein-like I0.00006567Direct
Voltage-gated potassium channels0.0000958Direct
Periplasmic binding protein-like II0.0005312Direct
PYP-like sensor domain (PAS domain)0.003135Inherited
p53-like transcription factors0.004548Inherited
Hormone receptor domain0.006923Inherited
Homeodomain-like0.007888Inherited
HLH, helix-loop-helix DNA-binding domain0.02886Inherited
ACT-like0.03333Inherited
SNF-like0.03721Inherited
Flavoproteins0.0487Inherited
Transcription factor STAT-4 N-domain0.0487Inherited
STAT0.0487Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0605Inherited
Riboflavin synthase domain-like0.0605Inherited
Transducin (alpha subunit), insertion domain0.06136Inherited
Glycosyl hydrolase domain0.1599Inherited
PDZ domain-like0.221Inherited
PreATP-grasp domain0.2304Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.2468Inherited
Glutathione synthetase ATP-binding domain-like0.2711Inherited
(Trans)glycosidases0.3225Inherited
Protein kinase-like (PK-like)0.3551Inherited
Second domain of FERM0.3858Inherited
Spectrin repeat0.4596Inherited
Chromo domain-like0.5897Inherited
Cadherin-like0.677Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
C-terminal domain of PLC-beta0Direct
SRF-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Steroid-binding domain0Direct
D-aminoacid oxidase-like0Direct
p53 DNA-binding domain-like0Direct
Phenylalanine metabolism regulatory domain0Direct
p53 tetramerization domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Metallothionein0Direct
IP3 receptor type 1 binding core, domain 20Direct
Synapsin domain0Direct
Neurotrophin0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
MutT-like0Direct
Synapsin C-terminal domain0Direct
Rhodopsin-like0.0000005042Direct
Nuclear receptor0.000006748Direct
Nicotinic receptor ligand binding domain-like0.000006808Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000006808Direct
Nuclear receptor ligand-binding domain0.00002931Direct
Phosphate binding protein-like0.00003418Direct
L-arabinose binding protein-like0.000494Direct
Tetramerization domain of potassium channels0.002726Inherited
Clathrin adaptor core protein0.004608Inherited
Hormone receptor domain0.005115Inherited
YWTD domain0.008258Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.008258Inherited
Homeodomain0.008676Inherited
Voltage-gated potassium channels0.01738Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.02431Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.02431Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02512Inherited
NADPH-cytochrome p450 reductase-like0.02512Inherited
HLH, helix-loop-helix DNA-binding domain0.02589Inherited
Cytoplasmic domain of inward rectifier potassium channel0.02742Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.0292Inherited
SNF-like0.0292Inherited
Laminin-type module0.03014Inherited
STAT0.0379Inherited
L domain0.0379Inherited
Transcription factor STAT-4 N-domain0.0379Inherited
STAT DNA-binding domain0.0379Inherited
Laminin G-like module0.04864Inherited
Transducin (alpha subunit), insertion domain0.04997Inherited
beta-glycanases0.05422Inherited
Pyridoxal-dependent decarboxylase0.07316Inherited
ZZ domain0.08076Inherited
Acetylcholinesterase-like0.1321Inherited
Leucine zipper domain0.1544Inherited
PDZ domain0.1576Inherited
BAR domain0.2152Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.2198Inherited
Spectrin repeat0.2774Inherited
Long-chain cytokines0.3253Inherited
Myb/SANT domain0.3613Inherited
Chromo domain0.4268Inherited
Protein kinases, catalytic subunit0.5072Inherited
T-box0.5352Inherited
Cadherin0.6971Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SRF-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
p53 tetramerization domain0Direct
C-terminal domain of PLC-beta0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Metallothionein0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Family A G protein-coupled receptor-like0.000000004663Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000004282Direct
Nicotinic receptor ligand binding domain-like0.000004282Direct
Nuclear receptor ligand-binding domain0.00001886Direct
Periplasmic binding protein-like I0.0000311Direct
Voltage-gated potassium channels0.00004606Direct
Periplasmic binding protein-like II0.0002813Direct
PYP-like sensor domain (PAS domain)0.001823Inherited
p53-like transcription factors0.002701Inherited
Hormone receptor domain0.004239Inherited
Homeodomain-like0.004853Inherited
YWTD domain0.006967Inherited
HLH, helix-loop-helix DNA-binding domain0.01955Inherited
ACT-like0.02283Inherited
SNF-like0.0257Inherited
Transcription factor STAT-4 N-domain0.03432Inherited
STAT0.03432Inherited
Flavoproteins0.03432Inherited
Riboflavin synthase domain-like0.0436Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0436Inherited
Transducin (alpha subunit), insertion domain0.04431Inherited
Glycosyl hydrolase domain0.1275Inherited
Leucine zipper domain0.135Inherited
PDZ domain-like0.1828Inherited
PreATP-grasp domain0.1915Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.2068Inherited
Glutathione synthetase ATP-binding domain-like0.2295Inherited
(Trans)glycosidases0.2783Inherited
Protein kinase-like (PK-like)0.3096Inherited
Second domain of FERM0.3394Inherited
SH3-domain0.3656Inherited
Spectrin repeat0.4118Inherited
Chromo domain-like0.5436Inherited
Cadherin-like0.635Inherited
GTPase activation domain, GAP0.9938Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    56496,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57535,49854
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    103473,103473
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 0Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0Direct
    57196,56496
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.000004282Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001474Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0008172Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.001327Inherited
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.01018Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01447Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01516Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.02156Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.02283Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.02428Inherited
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.02428Inherited
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.03432Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.03432Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.03432Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.03432Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03432Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03432Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07218Inherited
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0.1216Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1275Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1275Inherited
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.1276Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.4944Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.7428Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,56496,49899
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    49785,49899,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    56496,49899,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49854,57535,49854
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    49899,57196,56496
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57535,49854,57535
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    103473,103473,141571
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 141571 - Pentapeptide repeat-like
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.000414Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.003589Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01018Inherited
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.01018Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.02283Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03432Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.03432Inherited
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.03432Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03432Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.06721Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.2383Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.8681Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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