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Mammalian Phenotype (MP): reproductive system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   reproductive system phenotype [MP:0005389] <2>(37|56) (46|17|6)
- 1:   abnormal reproductive system morphology [MP:0002160] <12>(27|44) (36|14|6)
- 1:   abnormal reproductive system physiology [MP:0001919] <10>(21|37) (27|10|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Fibrinogen coiled-coil and central regions0Direct
p53 tetramerization domain0Direct
Nuclear receptor ligand-binding domain0.0000001665Direct
Cystine-knot cytokines0.0000001737Direct
Tudor/PWWP/MBT0.00008651Direct
SMAD MH1 domain0.0001332Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0002462Direct
Protein kinase-like (PK-like)0.005647Inherited
Cysteine-rich DNA binding domain, (DM domain)0.006278Inherited
E2F-DP heterodimerization region0.006278Inherited
4-helical cytokines0.01047Inherited
PAZ domain0.01512Inherited
HMA, heavy metal-associated domain0.01694Inherited
The spindle assembly checkpoint protein mad20.01694Inherited
Bcl-2 inhibitors of programmed cell death0.02883Inherited
Flavoproteins0.03741Inherited
Transcription factor STAT-4 N-domain0.03741Inherited
STAT0.03741Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03818Inherited
Homeodomain-like0.04157Inherited
LDL receptor-like module0.1195Inherited
Alpha-macroglobulin receptor domain0.1341Inherited
PYP-like sensor domain (PAS domain)0.1918Inherited
Nucleic acid-binding proteins0.2028Inherited
Blood coagulation inhibitor (disintegrin)0.2214Inherited
Metalloproteases ("zincins"), catalytic domain0.2444Inherited
SMAD/FHA domain0.251Inherited
EGF/Laminin0.2564Inherited
SAICAR synthase-like0.2702Inherited
Alkaline phosphatase-like0.2853Inherited
Terpenoid cyclases/Protein prenyltransferases0.2994Inherited
HMG-box0.3614Inherited
Fibronectin type III0.5296Inherited
L domain-like0.6623Inherited
BAR/IMD domain-like0.6795Inherited
Immunoglobulin1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Retinoblastoma tumor suppressor domains0Direct
Fibrinogen coiled-coil and central regions0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Nuclear receptor ligand-binding domain0.0000001265Direct
Nuclear receptor0.0000009051Direct
Transforming growth factor (TGF)-beta0.000003351Direct
Tudor domain0.00001387Direct
SMAD domain0.0000828Direct
SMAD MH1 domain0.0000828Direct
E2F dimerization segment0.001083Inherited
Short-chain cytokines0.002734Inherited
Gonadodropin/Follitropin0.003759Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.003759Inherited
NADPH-cytochrome p450 reductase-like0.003759Inherited
DNA repair protein MutS, domain III0.003759Inherited
Linker histone H1/H50.004107Inherited
Insulin-like0.004107Inherited
L domain0.004456Inherited
Cysteine-rich DNA binding domain, (DM domain)0.004456Inherited
Extracellular domain of cell surface receptors0.008992Inherited
Protein kinases, catalytic subunit0.00945Inherited
PAZ domain0.01122Inherited
HMA, heavy metal-associated domain0.01234Inherited
gamma-adaptin C-terminal appendage domain-like0.01234Inherited
The spindle assembly checkpoint protein mad20.01234Inherited
Neurotrophin0.01234Inherited
PHD domain0.01247Inherited
Cell cycle transcription factor e2f-dp0.02211Inherited
Bcl-2 inhibitors of programmed cell death0.02211Inherited
STAT0.02874Inherited
Single strand DNA-binding domain, SSB0.02874Inherited
Transcription factor STAT-4 N-domain0.02874Inherited
STAT DNA-binding domain0.02874Inherited
Nuclear receptor coactivator interlocking domain0.03586Inherited
Long-chain cytokines0.05993Inherited
Homeodomain0.0654Inherited
Astacin0.07046Inherited
Histone lysine methyltransferases0.07407Inherited
LDL receptor-like module0.1051Inherited
Complement components0.1134Inherited
Alpha-macroglobulin receptor domain0.1134Inherited
Forkhead DNA-binding domain0.1633Inherited
Growth factor receptor domain0.1778Inherited
Reprolysin-like0.1989Inherited
EGF-type module0.1991Inherited
Blood coagulation inhibitor (disintegrin)0.1995Inherited
ABC transporter ATPase domain-like0.2833Inherited
HMG-box0.3438Inherited
Fibronectin type III0.535Inherited
Ngr ectodomain-like0.6229Inherited
I set domains0.8974Inherited
Rhodopsin-like0.9875Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Nuclear receptor ligand-binding domain0.00000006616Direct
Cystine-knot cytokines0.00000006902Direct
Tudor/PWWP/MBT0.00004145Direct
SMAD MH1 domain0.00006594Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0001254Direct
DNA repair protein MutS, domain III0.00326Inherited
Protein kinase-like (PK-like)0.003404Inherited
Insulin-like0.003485Inherited
Cysteine-rich DNA binding domain, (DM domain)0.003817Inherited
E2F-DP heterodimerization region0.003817Inherited
4-helical cytokines0.006572Inherited
PAZ domain0.00972Inherited
The spindle assembly checkpoint protein mad20.01101Inherited
HMA, heavy metal-associated domain0.01101Inherited
Bcl-2 inhibitors of programmed cell death0.01953Inherited
Transcription factor STAT-4 N-domain0.02584Inherited
STAT0.02584Inherited
Flavoproteins0.02584Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0264Inherited
Homeodomain-like0.02896Inherited
Nuclear receptor coactivator interlocking domain0.03265Inherited
"Winged helix" DNA-binding domain0.04195Inherited
LDL receptor-like module0.0922Inherited
Alpha-macroglobulin receptor domain0.1048Inherited
Growth factor receptor domain0.1414Inherited
PYP-like sensor domain (PAS domain)0.156Inherited
Nucleic acid-binding proteins0.1659Inherited
Blood coagulation inhibitor (disintegrin)0.1832Inherited
Metalloproteases ("zincins"), catalytic domain0.2046Inherited
SMAD/FHA domain0.2108Inherited
EGF/Laminin0.2158Inherited
SAICAR synthase-like0.2287Inherited
Ribonuclease H-like0.2295Inherited
Alkaline phosphatase-like0.2429Inherited
dsRNA-binding domain-like0.2429Inherited
Terpenoid cyclases/Protein prenyltransferases0.2561Inherited
HMG-box0.3157Inherited
Cytochrome P4500.4418Inherited
Fibronectin type III0.4825Inherited
L domain-like0.6197Inherited
BAR/IMD domain-like0.6376Inherited
Family A G protein-coupled receptor-like0.9642Inherited
Immunoglobulin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001324Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00326Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.003817Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.003817Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003817Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.02584Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02584Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02584Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.03265Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05256Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.1513Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.1832Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3282Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4648Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.939Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003817Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02584Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02584Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1703Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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