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Mammalian Phenotype (MP): skeleton phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
- 1:   abnormal skeleton morphology [MP:0005508] <15>(41|59) (47|38|25)
- 1:   abnormal skeleton physiology [MP:0001533] <12>(17|20) (18|12|6)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
BTG domain-like0Direct
Homeodomain-like0Direct
p53 tetramerization domain0Direct
p53-like transcription factors0.000002792Direct
Growth factor receptor domain0.00001016Direct
EGF/Laminin0.00006845Direct
FnI-like domain0.001358Inherited
(Trans)glycosidases0.005662Inherited
TIMP-like0.007919Inherited
HLH, helix-loop-helix DNA-binding domain0.008815Inherited
Cystine-knot cytokines0.009569Inherited
Kringle-like0.01199Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01742Inherited
TB module/8-cys domain0.01995Inherited
Hect, E3 ligase catalytic domain0.02403Inherited
SCOP hierarchy in SUPERFAMILY0.02943Inherited
Nuclear receptor ligand-binding domain0.03403Inherited
Bromodomain0.04207Inherited
GLA-domain0.0466Inherited
Integrin beta tail domain0.04668Inherited
Leucine zipper domain0.0489Inherited
Transducin (alpha subunit), insertion domain0.05202Inherited
PGBD-like0.05467Inherited
Hemopexin-like domain0.05571Inherited
Clc chloride channel0.07917Inherited
HMG-box0.08597Inherited
TNF-like0.09089Inherited
TNF receptor-like0.09343Inherited
YWTD domain0.09406Inherited
Flavoproteins0.1562Inherited
TSP-1 type 1 repeat0.1842Inherited
Metalloproteases ("zincins"), catalytic domain0.197Inherited
4-helical cytokines0.1976Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2105Inherited
Riboflavin synthase domain-like0.2105Inherited
Spermadhesin, CUB domain0.2215Inherited
PYP-like sensor domain (PAS domain)0.2451Inherited
Kazal-type serine protease inhibitors0.2451Inherited
Glycosyl hydrolase domain0.2764Inherited
lambda repressor-like DNA-binding domains0.3235Inherited
L domain-like0.5023Inherited
Cyclin-like0.5577Inherited
Nicotinic receptor ligand binding domain-like0.742Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.742Inherited
Toll/Interleukin receptor TIR domain0.7658Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
BTG domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
p53 DNA-binding domain-like0Direct
Clathrin adaptor appendage, alpha and beta chain-specific domain0Direct
p53 tetramerization domain0Direct
Homeodomain0Direct
Alpha-adaptin ear subdomain-like0Direct
Growth factor receptor domain0.0001252Direct
Paired domain0.0007247Direct
VWC domain0.0007678Direct
DIX domain0.001561Inherited
Transforming growth factor (TGF)-beta0.001915Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.002239Inherited
Extracellular domain of cell surface receptors0.002239Inherited
T-box0.002837Inherited
Notch domain0.005019Inherited
EGF-type module0.005391Inherited
Arylsulfatase0.006012Inherited
HLH, helix-loop-helix DNA-binding domain0.00834Inherited
Hect, E3 ligase catalytic domain0.01397Inherited
TB module/8-cys domain0.01532Inherited
beta-glycanases0.01548Inherited
Cytochrome p450 reductase N-terminal domain-like0.01548Inherited
MBT repeat0.01703Inherited
Nuclear receptor0.0196Inherited
TNF receptor-like0.02185Inherited
I set domains0.02305Inherited
Fibroblast growth factors (FGF)0.02601Inherited
Kringle modules0.02867Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.02867Inherited
Nuclear receptor ligand-binding domain0.02973Inherited
Laminin G-like module0.03512Inherited
Bromodomain0.03567Inherited
Integrin beta tail domain0.03699Inherited
GLA-domain0.03773Inherited
Transducin (alpha subunit), insertion domain0.04278Inherited
Leucine zipper domain0.04348Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.04428Inherited
NADPH-cytochrome p450 reductase-like0.04428Inherited
Laminin-type module0.04558Inherited
MMP N-terminal domain0.04558Inherited
Hemopexin-like domain0.04691Inherited
Matrix metalloproteases, catalytic domain0.06159Inherited
Clc chloride channel0.06523Inherited
HMG-box0.07676Inherited
YWTD domain0.08005Inherited
Forkhead DNA-binding domain0.08109Inherited
TNF-like0.08109Inherited
DEATH domain, DD0.1145Inherited
Classic zinc finger, C2H20.1307Inherited
Neutral endopeptidase (neprilysin)0.135Inherited
TSP-1 type 1 repeat0.172Inherited
Spermadhesin, CUB domain0.2088Inherited
Long-chain cytokines0.3442Inherited
Ngr ectodomain-like0.4326Inherited
EF-hand modules in multidomain proteins0.5018Inherited
SAM (sterile alpha motif) domain0.5308Inherited
Toll/Interleukin receptor TIR domain0.7177Inherited
Nicotinic receptor ligand binding domain-like0.7335Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7335Inherited
G proteins0.8732Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
BTG domain-like0Direct
Homeodomain-like0Direct
p53-like transcription factors0.000001172Direct
Growth factor receptor domain0.000004464Direct
EGF/Laminin0.00003248Direct
FnI-like domain0.0007556Direct
(Trans)glycosidases0.003415Inherited
Notch domain0.004295Inherited
TIMP-like0.004873Inherited
HLH, helix-loop-helix DNA-binding domain0.005455Inherited
Cystine-knot cytokines0.005965Inherited
Kringle-like0.007596Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01135Inherited
TB module/8-cys domain0.0131Inherited
Hect, E3 ligase catalytic domain0.01601Inherited
Frizzled cysteine-rich domain0.02041Inherited
Nuclear receptor ligand-binding domain0.02336Inherited
Alkaline phosphatase-like0.02732Inherited
Bromodomain0.02933Inherited
GLA-domain0.03281Inherited
Integrin beta tail domain0.03286Inherited
Leucine zipper domain0.03449Inherited
Transducin (alpha subunit), insertion domain0.03685Inherited
PGBD-like0.03895Inherited
Hemopexin-like domain0.03976Inherited
Clc chloride channel0.05841Inherited
HMG-box0.06394Inherited
TNF-like0.06797Inherited
TNF receptor-like0.07005Inherited
YWTD domain0.07055Inherited
Flavoproteins0.1242Inherited
TSP-1 type 1 repeat0.1491Inherited
Metalloproteases ("zincins"), catalytic domain0.1605Inherited
4-helical cytokines0.1611Inherited
Riboflavin synthase domain-like0.1728Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1728Inherited
Spermadhesin, CUB domain0.1833Inherited
Kazal-type serine protease inhibitors0.2054Inherited
PYP-like sensor domain (PAS domain)0.2054Inherited
beta-beta-alpha zinc fingers0.2085Inherited
LDL receptor-like module0.2157Inherited
Glycosyl hydrolase domain0.2345Inherited
lambda repressor-like DNA-binding domains0.2793Inherited
L domain-like0.4547Inherited
Cyclin-like0.5111Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7035Inherited
Nicotinic receptor ligand binding domain-like0.7035Inherited
Toll/Interleukin receptor TIR domain0.7284Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00006681Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.001299Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.001686Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001715Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.001818Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.004295Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.005266Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.009204Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0101Inherited
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0.01362Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.01362Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.01482Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.01482Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.01482Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.02588Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02588Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03281Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.03286Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.03286Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.03895Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.03991Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.05841Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07055Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.07055Inherited
    48726,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 0.07751Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1004Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.124Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.124Inherited
    63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0.1297Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1558Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.1773Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2231Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.2345Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.2656Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2947Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.7035Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0006312Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.001299Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003561Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.003561Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004295Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.004295Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.005266Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0131Inherited
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.01362Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.01482Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01482Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.02454Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.03286Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03785Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03964Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.03991Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.03991Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05841Inherited
    48726,56436,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.07751Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.09561Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.09561Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.8426Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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