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Mammalian Phenotype (MP): vision/eye phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   vision/eye phenotype [MP:0005391] <2>(43|53) (50|27|17)
- 1:   abnormal eye physiology [MP:0005253] <25>(8|9) (9|5|2)
- 1:   abnormal eye morphology [MP:0002092] <23>(39|49) (46|25|15)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Notch domain0Direct
Tubby C-terminal domain-like0Direct
p53 tetramerization domain0Direct
Di-copper centre-containing domain0Direct
gamma-Crystallin-like0.000001659Direct
EGF/Laminin0.00003213Direct
FnI-like domain0.0002634Direct
Plexin repeat0.0005154Direct
Cystine-knot cytokines0.001084Inherited
Homeodomain-like0.001113Inherited
HLH, helix-loop-helix DNA-binding domain0.003784Inherited
CalX-like0.005553Inherited
Sema domain0.01038Inherited
Nuclear receptor ligand-binding domain0.0226Inherited
GroEL equatorial domain-like0.02425Inherited
GAF domain-like0.04757Inherited
TNF-like0.05769Inherited
Transducin (heterotrimeric G protein), gamma chain0.07059Inherited
E2F-DP heterodimerization region0.07692Inherited
Cupredoxins0.08183Inherited
PGBD-like0.08649Inherited
HMG-box0.08978Inherited
Clc chloride channel0.111Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1238Inherited
Integrin domains0.1436Inherited
CBS-domain pair0.1555Inherited
Cyclin-like0.1653Inherited
Kringle-like0.1742Inherited
"Winged helix" DNA-binding domain0.1938Inherited
Tetraspanin0.223Inherited
Metalloproteases ("zincins"), catalytic domain0.3457Inherited
HD-domain/PDEase-like0.3702Inherited
Blood coagulation inhibitor (disintegrin)0.3702Inherited
Regulator of G-protein signaling, RGS0.3702Inherited
Transducin (alpha subunit), insertion domain0.4067Inherited
Nicotinic receptor ligand binding domain-like0.4215Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4215Inherited
Toll/Interleukin receptor TIR domain0.5159Inherited
L domain-like0.5362Inherited
NAD(P)-binding Rossmann-fold domains0.5378Inherited
DBL homology domain (DH-domain)0.7952Inherited
Trypsin-like serine proteases0.9865Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 DNA-binding domain-like0Direct
Transcriptional factor tubby, C-terminal domain0Direct
Notch domain0Direct
p53 tetramerization domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Crystallins/Ca-binding development proteins0.000001047Direct
VWC domain0.0000661Direct
Arylsulfatase0.0000938Direct
Forkhead DNA-binding domain0.0001042Direct
Plexin repeat0.0003902Direct
Homeodomain0.0005354Direct
EGF-type module0.0005409Direct
I set domains0.001714Inherited
HLH, helix-loop-helix DNA-binding domain0.003415Inherited
CalX-beta domain0.003991Inherited
Noncollagenous (NC1) domain of collagen IV0.005378Inherited
YWTD domain0.005848Inherited
Sema domain0.008274Inherited
Laminin-type module0.008778Inherited
Transforming growth factor (TGF)-beta0.01253Inherited
Nuclear receptor0.01312Inherited
Extracellular domain of cell surface receptors0.01496Inherited
Nuclear receptor ligand-binding domain0.01922Inherited
E2F dimerization segment0.03726Inherited
GAF domain0.03726Inherited
TNF-like0.04968Inherited
MMP N-terminal domain0.07326Inherited
HMG-box0.07914Inherited
Matrix metalloproteases, catalytic domain0.09128Inherited
Clc chloride channel0.09358Inherited
Tyrosine-dependent oxidoreductases0.09593Inherited
CBS-domain pair0.107Inherited
TNF receptor-like0.1113Inherited
Integrin domains0.1276Inherited
Transducin (heterotrimeric G protein), gamma chain0.1283Inherited
Cell cycle transcription factor e2f-dp0.1283Inherited
Kringle modules0.1675Inherited
Calmodulin-like0.1931Inherited
PDZ domain0.2346Inherited
PDEase0.2725Inherited
POU-specific domain0.2725Inherited
Ngr ectodomain-like0.2882Inherited
Blood coagulation inhibitor (disintegrin)0.3482Inherited
Regulator of G-protein signaling, RGS0.3518Inherited
Transducin (alpha subunit), insertion domain0.3821Inherited
Nicotinic receptor ligand binding domain-like0.4058Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4058Inherited
cAMP-binding domain0.4181Inherited
Cyclin0.5481Inherited
DBL homology domain (DH-domain)0.7868Inherited
Eukaryotic proteases0.9918Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Notch domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Di-copper centre-containing domain0Direct
Tubby C-terminal domain-like0Direct
gamma-Crystallin-like0.0000006815Direct
EGF/Laminin0.00001475Direct
FnI-like domain0.0001348Direct
Plexin repeat0.0002725Direct
Cystine-knot cytokines0.0005947Direct
Homeodomain-like0.0006109Direct
Alkaline phosphatase-like0.001034Inherited
Growth factor receptor domain0.001087Inherited
Integrin beta tail domain0.00122Inherited
HLH, helix-loop-helix DNA-binding domain0.002221Inherited
CalX-like0.003344Inherited
YWTD domain0.00478Inherited
Sema domain0.006505Inherited
Nuclear receptor ligand-binding domain0.01498Inherited
GroEL equatorial domain-like0.01617Inherited
GAF domain-like0.03351Inherited
TNF-like0.04135Inherited
Transducin (heterotrimeric G protein), gamma chain0.05166Inherited
E2F-DP heterodimerization region0.05666Inherited
Cupredoxins0.06057Inherited
PGBD-like0.06438Inherited
HMG-box0.06702Inherited
Clc chloride channel0.08494Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.09583Inherited
Integrin domains0.1131Inherited
beta-sandwich domain of Sec23/240.1177Inherited
CBS-domain pair0.1236Inherited
Cyclin-like0.1321Inherited
Kringle-like0.1399Inherited
"Winged helix" DNA-binding domain0.1577Inherited
Tetraspanin0.1847Inherited
TNF receptor-like0.2025Inherited
Metalloproteases ("zincins"), catalytic domain0.3004Inherited
Regulator of G-protein signaling, RGS0.3243Inherited
Blood coagulation inhibitor (disintegrin)0.3243Inherited
HD-domain/PDEase-like0.3243Inherited
Transducin (alpha subunit), insertion domain0.3599Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3747Inherited
Nicotinic receptor ligand binding domain-like0.3747Inherited
Toll/Interleukin receptor TIR domain0.4685Inherited
L domain-like0.4891Inherited
NAD(P)-binding Rossmann-fold domains0.4908Inherited
Intermediate filament protein, coiled coil region0.7488Inherited
DBL homology domain (DH-domain)0.7602Inherited
Trypsin-like serine proteases0.9708Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000003677Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.00122Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002829Inherited
    48670,48097
  • 48670 - Transducin (heterotrimeric G protein), gamma chain
  • 48097 - Regulator of G-protein signaling, RGS
  • 0.005149Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.005442Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.006505Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.00715Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.01096Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.01096Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.02085Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.03351Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03351Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.05666Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.06438Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.08494Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.1071Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.2181Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.2622Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3175Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.3243Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.3604Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3747Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.7206Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    49265,48726,49265
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00001545Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.00122Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.004587Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.005539Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.007747Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.01263Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01617Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01617Inherited
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02085Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03351Inherited
    50156,50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.05666Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.07242Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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