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Mammalian Phenotype (MP): vision/eye phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   vision/eye phenotype [MP:0005391] <2>(43|53) (50|27|17)
- 1:   abnormal eye physiology [MP:0005253] <25>(8|9) (9|5|2)
- 1:   abnormal eye morphology [MP:0002092] <23>(39|49) (46|25|15)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Tubby C-terminal domain-like0Direct
p53 tetramerization domain0Direct
Di-copper centre-containing domain0Direct
Notch domain0Direct
gamma-Crystallin-like0.000001654Direct
EGF/Laminin0.00003168Direct
FnI-like domain0.0002626Direct
Plexin repeat0.0007391Direct
Cystine-knot cytokines0.001078Inherited
Homeodomain-like0.0011Inherited
HLH, helix-loop-helix DNA-binding domain0.003763Inherited
CalX-like0.005544Inherited
Sema domain0.01356Inherited
Nuclear receptor ligand-binding domain0.02254Inherited
GroEL equatorial domain-like0.02423Inherited
GAF domain-like0.0475Inherited
TNF-like0.05753Inherited
Transducin (heterotrimeric G protein), gamma chain0.07054Inherited
E2F-DP heterodimerization region0.07687Inherited
Cupredoxins0.08172Inherited
PGBD-like0.08636Inherited
HMG-box0.08961Inherited
Clc chloride channel0.1109Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1235Inherited
Integrin domains0.1434Inherited
CBS-domain pair0.1554Inherited
Cyclin-like0.165Inherited
Kringle-like0.174Inherited
"Winged helix" DNA-binding domain0.1936Inherited
Tetraspanin0.2229Inherited
Metalloproteases ("zincins"), catalytic domain0.3454Inherited
Regulator of G-protein signaling, RGS0.3698Inherited
HD-domain/PDEase-like0.3699Inherited
Blood coagulation inhibitor (disintegrin)0.3699Inherited
Transducin (alpha subunit), insertion domain0.4064Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4211Inherited
Nicotinic receptor ligand binding domain-like0.4211Inherited
Toll/Interleukin receptor TIR domain0.5156Inherited
L domain-like0.5355Inherited
NAD(P)-binding Rossmann-fold domains0.5373Inherited
DBL homology domain (DH-domain)0.7948Inherited
Trypsin-like serine proteases0.9865Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Transcriptional factor tubby, C-terminal domain0Direct
p53 DNA-binding domain-like0Direct
Notch domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Crystallins/Ca-binding development proteins0.000001044Direct
VWC domain0.00006576Direct
Arylsulfatase0.00009349Direct
Forkhead DNA-binding domain0.0001033Direct
Homeodomain0.0005273Direct
EGF-type module0.0005349Direct
Plexin repeat0.0005567Direct
I set domains0.002003Inherited
HLH, helix-loop-helix DNA-binding domain0.003376Inherited
CalX-beta domain0.003969Inherited
Noncollagenous (NC1) domain of collagen IV0.00535Inherited
YWTD domain0.005811Inherited
Laminin-type module0.008723Inherited
Sema domain0.01087Inherited
Transforming growth factor (TGF)-beta0.01245Inherited
Nuclear receptor0.01303Inherited
Extracellular domain of cell surface receptors0.01489Inherited
Nuclear receptor ligand-binding domain0.01911Inherited
GAF domain0.03718Inherited
E2F dimerization segment0.03718Inherited
TNF-like0.04945Inherited
MMP N-terminal domain0.07306Inherited
HMG-box0.07882Inherited
Matrix metalloproteases, catalytic domain0.09102Inherited
Clc chloride channel0.09338Inherited
Tyrosine-dependent oxidoreductases0.0956Inherited
CBS-domain pair0.1067Inherited
TNF receptor-like0.111Inherited
Integrin domains0.1273Inherited
Transducin (heterotrimeric G protein), gamma chain0.1281Inherited
Cell cycle transcription factor e2f-dp0.1281Inherited
Kringle modules0.1672Inherited
Calmodulin-like0.1927Inherited
PDZ domain0.234Inherited
PDEase0.2722Inherited
POU-specific domain0.2722Inherited
Ngr ectodomain-like0.2875Inherited
Blood coagulation inhibitor (disintegrin)0.3478Inherited
Regulator of G-protein signaling, RGS0.3513Inherited
Transducin (alpha subunit), insertion domain0.3817Inherited
Nicotinic receptor ligand binding domain-like0.4054Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4054Inherited
cAMP-binding domain0.4176Inherited
Cyclin0.5476Inherited
DBL homology domain (DH-domain)0.7863Inherited
Eukaryotic proteases0.9917Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Tubby C-terminal domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Di-copper centre-containing domain0Direct
Notch domain0Direct
p53 tetramerization domain0Direct
gamma-Crystallin-like0.0000006795Direct
EGF/Laminin0.00001457Direct
FnI-like domain0.0001343Direct
Plexin repeat0.0003967Direct
Cystine-knot cytokines0.0005914Direct
Homeodomain-like0.0006047Direct
Alkaline phosphatase-like0.001031Inherited
Growth factor receptor domain0.001078Inherited
Integrin beta tail domain0.001217Inherited
HLH, helix-loop-helix DNA-binding domain0.002207Inherited
CalX-like0.003335Inherited
YWTD domain0.004766Inherited
Sema domain0.008655Inherited
Nuclear receptor ligand-binding domain0.01493Inherited
GroEL equatorial domain-like0.01614Inherited
GAF domain-like0.03345Inherited
TNF-like0.04123Inherited
Transducin (heterotrimeric G protein), gamma chain0.05159Inherited
E2F-DP heterodimerization region0.0566Inherited
Cupredoxins0.06047Inherited
PGBD-like0.06426Inherited
HMG-box0.06688Inherited
Clc chloride channel0.08485Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.09553Inherited
Integrin domains0.1129Inherited
beta-sandwich domain of Sec23/240.1175Inherited
CBS-domain pair0.1235Inherited
Cyclin-like0.1319Inherited
Kringle-like0.1398Inherited
"Winged helix" DNA-binding domain0.1575Inherited
Tetraspanin0.1845Inherited
TNF receptor-like0.2023Inherited
Metalloproteases ("zincins"), catalytic domain0.3Inherited
Regulator of G-protein signaling, RGS0.324Inherited
Blood coagulation inhibitor (disintegrin)0.3241Inherited
HD-domain/PDEase-like0.3241Inherited
Transducin (alpha subunit), insertion domain0.3596Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3743Inherited
Nicotinic receptor ligand binding domain-like0.3743Inherited
Toll/Interleukin receptor TIR domain0.4681Inherited
L domain-like0.4884Inherited
NAD(P)-binding Rossmann-fold domains0.4903Inherited
Intermediate filament protein, coiled coil region0.7484Inherited
DBL homology domain (DH-domain)0.7598Inherited
Trypsin-like serine proteases0.9707Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000003648Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001217Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00282Inherited
    48670,48097
  • 48670 - Transducin (heterotrimeric G protein), gamma chain
  • 48097 - Regulator of G-protein signaling, RGS
  • 0.005137Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.005419Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.007133Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.008655Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.01094Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.01094Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.02081Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.03345Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03345Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0566Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.06426Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.08485Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.107Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.2178Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.262Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3174Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.3241Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.36Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3743Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.7203Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    49265,48726,49265
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00001535Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001217Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.004576Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.005519Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.007725Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.0126Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01614Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01614Inherited
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02081Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03345Inherited
    50156,50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.0566Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.07234Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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