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Mammalian Phenotype (MP): integument phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   integument phenotype [MP:0010771] <5>(46|64) (53|34|18)
- 1:   abnormal skin morphology [MP:0002060] <16>(19|26) (24|13|8)
- 1:   abnormal skin adnexa morphology [MP:0010678] <12>(21|28) (23|21|10)
- 1:   abnormal skin physiology [MP:0005501] <12>(6|10) (7|1|0)
- 1:   abnormal touch/ nociception [MP:0001968] <7>(9|9) (9|5|0)
- 1:   abnormal skin adnexa physiology [MP:0010680] <6>(5|8) (6|7|4)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
p53 tetramerization domain0Direct
Lamin A/C globular tail domain0Direct
Di-copper centre-containing domain0Direct
p53-like transcription factors0.000001235Direct
Intermediate filament protein, coiled coil region0.000007109Direct
EGF/Laminin0.0001013Direct
Protein kinase-like (PK-like)0.0002533Direct
Integrin beta tail domain0.0003631Direct
Cytokine0.001135Inherited
Growth factor receptor domain0.001319Inherited
ACT-like0.00451Inherited
Notch domain0.00451Inherited
Nuclear receptor coactivator interlocking domain0.00451Inherited
Transcription factor STAT-4 N-domain0.005106Inherited
STAT0.005106Inherited
4-helical cytokines0.006783Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.008666Inherited
Nuclear receptor ligand-binding domain0.01232Inherited
Lipoxigenase0.01491Inherited
FnI-like domain0.01535Inherited
Band 7/SPFH domain0.03193Inherited
Periplasmic binding protein-like I0.03708Inherited
HLH, helix-loop-helix DNA-binding domain0.03924Inherited
DNA repair protein MutS, domain III0.04079Inherited
Homeodomain-like0.04677Inherited
Family A G protein-coupled receptor-like0.05569Inherited
SMAD MH1 domain0.05589Inherited
CalX-like0.05589Inherited
Transducin (alpha subunit), insertion domain0.08226Inherited
Leucine zipper domain0.1076Inherited
TNF receptor-like0.1207Inherited
Cadherin-like0.1315Inherited
Periplasmic binding protein-like II0.1453Inherited
Integrin domains0.154Inherited
PAZ domain0.1689Inherited
Frizzled cysteine-rich domain0.1932Inherited
L domain-like0.2159Inherited
Fibronectin type III0.2405Inherited
Cyclin-like0.2938Inherited
Nicotinic receptor ligand binding domain-like0.3452Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3452Inherited
vWA-like0.3619Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6072Inherited
Voltage-gated potassium channels0.6884Inherited
C-type lectin-like0.9989Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Phenylalanine metabolism regulatory domain0Direct
RUNT domain0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Lamin A/C globular tail domain0Direct
p53 tetramerization domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
Intermediate filament protein, coiled coil region0.000006383Direct
Integrin beta tail domain0.0002479Direct
EGF-type module0.0004637Direct
Growth factor receptor domain0.0005415Direct
Protein kinases, catalytic subunit0.0008341Direct
Plakin repeat0.0009086Direct
E2F dimerization segment0.0009086Direct
Integrin beta EGF-like domains0.001185Inherited
VWC domain0.002172Inherited
Nuclear receptor coactivator interlocking domain0.003253Inherited
Interleukin-1 (IL-1)0.003253Inherited
Notch domain0.003253Inherited
STAT0.003794Inherited
STAT DNA-binding domain0.003794Inherited
L domain0.003794Inherited
Transcription factor STAT-4 N-domain0.003794Inherited
Nuclear receptor0.007039Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01029Inherited
Nuclear receptor ligand-binding domain0.01133Inherited
Lipoxigenase N-terminal domain0.01143Inherited
Animal lipoxigenases0.01143Inherited
Fibroblast growth factors (FGF)0.01318Inherited
DNA repair protein MutS, domain III0.03242Inherited
Short-chain cytokines0.03607Inherited
Papain-like0.03607Inherited
TNF receptor-like0.03686Inherited
HLH, helix-loop-helix DNA-binding domain0.04071Inherited
SMAD MH1 domain0.04617Inherited
CalX-beta domain0.04617Inherited
SMAD domain0.04617Inherited
Ankyrin repeat0.04703Inherited
Rhodopsin-like0.05036Inherited
Long-chain cytokines0.05222Inherited
Laminin-type module0.06789Inherited
Transducin (alpha subunit), insertion domain0.07177Inherited
Phosphate binding protein-like0.08721Inherited
Cadherin0.09335Inherited
Leucine zipper domain0.104Inherited
Integrin A (or I) domain0.104Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.1042Inherited
L-arabinose binding protein-like0.1086Inherited
Homeodomain0.1234Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.131Inherited
Integrin domains0.1432Inherited
PAZ domain0.1497Inherited
Frizzled cysteine-rich domain0.1789Inherited
Paired domain0.2007Inherited
RING finger domain, C3HC40.2011Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.2537Inherited
Fibronectin type III0.2638Inherited
Ngr ectodomain-like0.2724Inherited
Nicotinic receptor ligand binding domain-like0.3404Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3404Inherited
FHA domain0.4042Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4432Inherited
C-type lectin domain0.9571Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Di-copper centre-containing domain0Direct
p53 tetramerization domain0Direct
p53-like transcription factors0.0000005059Direct
Intermediate filament protein, coiled coil region0.000003067Direct
EGF/Laminin0.00004896Direct
Protein kinase-like (PK-like)0.0001293Direct
Integrin beta tail domain0.0001889Direct
Cytokine0.0006242Direct
Plakin repeat0.0007243Direct
Growth factor receptor domain0.0007329Direct
Galactose oxidase, central domain0.002676Inherited
ACT-like0.002676Inherited
Notch domain0.002676Inherited
Nuclear receptor coactivator interlocking domain0.002676Inherited
STAT0.003059Inherited
Transcription factor STAT-4 N-domain0.003059Inherited
4-helical cytokines0.004146Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.005357Inherited
Nuclear receptor ligand-binding domain0.007819Inherited
Lipoxigenase0.009564Inherited
FnI-like domain0.009877Inherited
Band 7/SPFH domain0.02184Inherited
Periplasmic binding protein-like I0.02558Inherited
HLH, helix-loop-helix DNA-binding domain0.02717Inherited
DNA repair protein MutS, domain III0.02837Inherited
Homeodomain-like0.03293Inherited
Ankyrin repeat0.03426Inherited
SH2 domain0.0343Inherited
Family A G protein-coupled receptor-like0.03973Inherited
CalX-like0.03988Inherited
SMAD MH1 domain0.03988Inherited
Transducin (alpha subunit), insertion domain0.06089Inherited
DNA/RNA polymerases0.06373Inherited
Leucine zipper domain0.08192Inherited
TNF receptor-like0.09311Inherited
Cadherin-like0.1025Inherited
Periplasmic binding protein-like II0.1145Inherited
Integrin domains0.1223Inherited
PAZ domain0.1351Inherited
Frizzled cysteine-rich domain0.1572Inherited
L domain-like0.178Inherited
Fibronectin type III0.2009Inherited
Cyclin-like0.251Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2999Inherited
Nicotinic receptor ligand binding domain-like0.2999Inherited
vWA-like0.3162Inherited
Cysteine-rich domain0.5025Inherited
WD40 repeat-like0.5526Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5619Inherited
Voltage-gated potassium channels0.6469Inherited
C-type lectin-like0.9858Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.000004788Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0001889Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0007243Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0.002676Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002771Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.003059Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.003059Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003059Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.003059Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.003059Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.003059Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00328Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00463Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.009354Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.009477Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.009477Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.009564Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01433Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.01746Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02837Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.03988Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.04242Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04411Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.0635Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.06366Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.06366Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.06373Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.09304Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.2999Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0001889Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000238Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0002721Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.003059Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003059Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.003059Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.005716Inherited
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.009477Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.009564Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01701Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.02184Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.03009Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03988Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.04364Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.05899Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.09304Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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