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Mammalian Phenotype (MP): integument phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   integument phenotype [MP:0010771] <5>(46|64) (53|34|18)
- 1:   abnormal skin morphology [MP:0002060] <16>(19|26) (24|13|8)
- 1:   abnormal skin adnexa morphology [MP:0010678] <12>(21|28) (23|21|10)
- 1:   abnormal skin physiology [MP:0005501] <12>(6|10) (7|1|0)
- 1:   abnormal touch/ nociception [MP:0001968] <7>(9|9) (9|5|0)
- 1:   abnormal skin adnexa physiology [MP:0010680] <6>(5|8) (6|7|4)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Di-copper centre-containing domain0Direct
Lamin A/C globular tail domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
p53-like transcription factors0.00000123Direct
Intermediate filament protein, coiled coil region0.000007088Direct
EGF/Laminin0.0001009Direct
Protein kinase-like (PK-like)0.0002524Direct
Integrin beta tail domain0.0003631Direct
Cytokine0.001134Inherited
Growth factor receptor domain0.001317Inherited
Nuclear receptor coactivator interlocking domain0.004511Inherited
ACT-like0.004511Inherited
Notch domain0.004511Inherited
STAT0.005102Inherited
Transcription factor STAT-4 N-domain0.005102Inherited
4-helical cytokines0.006778Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.008644Inherited
Nuclear receptor ligand-binding domain0.01231Inherited
Lipoxigenase0.01491Inherited
FnI-like domain0.01534Inherited
Band 7/SPFH domain0.03193Inherited
Periplasmic binding protein-like I0.03707Inherited
HLH, helix-loop-helix DNA-binding domain0.03921Inherited
DNA repair protein MutS, domain III0.04079Inherited
Homeodomain-like0.04669Inherited
Family A G protein-coupled receptor-like0.05237Inherited
CalX-like0.05586Inherited
SMAD MH1 domain0.05586Inherited
Transducin (alpha subunit), insertion domain0.08222Inherited
Leucine zipper domain0.1075Inherited
TNF receptor-like0.1207Inherited
Cadherin-like0.1315Inherited
Periplasmic binding protein-like II0.1452Inherited
Integrin domains0.154Inherited
PAZ domain0.1689Inherited
Frizzled cysteine-rich domain0.1932Inherited
L domain-like0.2158Inherited
Fibronectin type III0.2404Inherited
Cyclin-like0.2938Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3452Inherited
Nicotinic receptor ligand binding domain-like0.3452Inherited
vWA-like0.3619Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6068Inherited
Voltage-gated potassium channels0.6881Inherited
C-type lectin-like0.999Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 DNA-binding domain-like0Direct
RUNT domain0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Phenylalanine metabolism regulatory domain0Direct
Intermediate filament protein, coiled coil region0.00000637Direct
Integrin beta tail domain0.0002478Direct
EGF-type module0.000463Direct
Growth factor receptor domain0.0005409Direct
Protein kinases, catalytic subunit0.00083Direct
Plakin repeat0.000909Direct
E2F dimerization segment0.000909Direct
Integrin beta EGF-like domains0.001184Inherited
VWC domain0.002171Inherited
Notch domain0.003251Inherited
Interleukin-1 (IL-1)0.003251Inherited
Nuclear receptor coactivator interlocking domain0.003251Inherited
STAT DNA-binding domain0.003794Inherited
Transcription factor STAT-4 N-domain0.003794Inherited
L domain0.003794Inherited
STAT0.003794Inherited
Nuclear receptor0.007034Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01029Inherited
Nuclear receptor ligand-binding domain0.01133Inherited
Animal lipoxigenases0.01143Inherited
Lipoxigenase N-terminal domain0.01143Inherited
Fibroblast growth factors (FGF)0.01317Inherited
DNA repair protein MutS, domain III0.03245Inherited
Short-chain cytokines0.03607Inherited
Papain-like0.03607Inherited
TNF receptor-like0.03689Inherited
HLH, helix-loop-helix DNA-binding domain0.04068Inherited
SMAD MH1 domain0.04618Inherited
CalX-beta domain0.04618Inherited
SMAD domain0.04618Inherited
Rhodopsin-like0.04691Inherited
Ankyrin repeat0.04699Inherited
Long-chain cytokines0.0522Inherited
Laminin-type module0.06788Inherited
Transducin (alpha subunit), insertion domain0.07177Inherited
Phosphate binding protein-like0.08724Inherited
Cadherin0.09336Inherited
Leucine zipper domain0.104Inherited
Integrin A (or I) domain0.104Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.1042Inherited
L-arabinose binding protein-like0.1086Inherited
Homeodomain0.1232Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.131Inherited
Integrin domains0.1432Inherited
PAZ domain0.1498Inherited
Frizzled cysteine-rich domain0.1789Inherited
Paired domain0.2007Inherited
RING finger domain, C3HC40.201Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.2537Inherited
Fibronectin type III0.2636Inherited
Ngr ectodomain-like0.2723Inherited
Nicotinic receptor ligand binding domain-like0.3404Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3404Inherited
FHA domain0.4041Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.443Inherited
C-type lectin domain0.9571Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Di-copper centre-containing domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
p53 tetramerization domain0Direct
Lamin A/C globular tail domain0Direct
p53-like transcription factors0.0000005046Direct
Intermediate filament protein, coiled coil region0.000003061Direct
EGF/Laminin0.00004879Direct
Protein kinase-like (PK-like)0.0001287Direct
Integrin beta tail domain0.0001889Direct
Cytokine0.000624Direct
Plakin repeat0.0007243Direct
Growth factor receptor domain0.000732Direct
Galactose oxidase, central domain0.002675Inherited
Notch domain0.002675Inherited
ACT-like0.002675Inherited
Nuclear receptor coactivator interlocking domain0.002675Inherited
STAT0.003057Inherited
Transcription factor STAT-4 N-domain0.003057Inherited
4-helical cytokines0.004142Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.005344Inherited
Nuclear receptor ligand-binding domain0.007811Inherited
Lipoxigenase0.009564Inherited
FnI-like domain0.009869Inherited
Band 7/SPFH domain0.02183Inherited
Periplasmic binding protein-like I0.02556Inherited
HLH, helix-loop-helix DNA-binding domain0.02714Inherited
DNA repair protein MutS, domain III0.02837Inherited
Homeodomain-like0.03286Inherited
Ankyrin repeat0.03422Inherited
Family A G protein-coupled receptor-like0.03713Inherited
SH2 domain0.0385Inherited
CalX-like0.03988Inherited
SMAD MH1 domain0.03988Inherited
Transducin (alpha subunit), insertion domain0.06086Inherited
DNA/RNA polymerases0.06372Inherited
Leucine zipper domain0.08185Inherited
TNF receptor-like0.0931Inherited
Cadherin-like0.1025Inherited
Periplasmic binding protein-like II0.1145Inherited
Integrin domains0.1223Inherited
PAZ domain0.1352Inherited
Frizzled cysteine-rich domain0.1572Inherited
L domain-like0.1779Inherited
Fibronectin type III0.2008Inherited
Cyclin-like0.2509Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2999Inherited
Nicotinic receptor ligand binding domain-like0.2999Inherited
vWA-like0.3161Inherited
Cysteine-rich domain0.5024Inherited
WD40 repeat-like0.5523Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5616Inherited
Voltage-gated potassium channels0.6466Inherited
C-type lectin-like0.9858Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.000004784Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0001889Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0007243Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0.002675Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00277Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.003057Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.003057Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.003057Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003057Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.003057Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.003057Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.003277Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004624Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.009348Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.009477Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.009477Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.009564Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01431Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.01745Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02837Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.03988Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0424Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04411Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.06347Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.06364Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.06364Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.06372Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.09303Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.2999Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0001889Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0002379Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0002719Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.003057Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.003057Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003057Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.005714Inherited
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.009477Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.009564Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01701Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.02183Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0301Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03988Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.04362Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.05891Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.09303Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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