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Mammalian Phenotype (MP): abnormal leukocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <30>
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(65|89) (71|57|28)
+ + + + 4:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(51|74) (62|43|19)
+ + + + 4:   immune system phenotype [MP:0005387] <2>(79|106) (85|60|29)
+ + + 3:   abnormal blood cell morphology/development [MP:0002429] <3>(44|67) (52|39|18)
+ + + 3:   abnormal immune system morphology [MP:0000685] <3>(46|70) (54|36|17)
+ + 2:   abnormal hematopoiesis [MP:0002123] <8>(44|67) (52|39|18)
+ + 2:   abnormal immune system cell morphology [MP:0000716] <5>(37|58) (40|31|16)
+ 1:   abnormal hematopoietic cell number [MP:0011180] <8>(27|50) (33|28|14)
+ 1:   abnormal leukocyte morphology [MP:0008246] <4>(37|58) (40|31|16)
0:   abnormal leukocyte cell number [MP:0000217] <7>(23|45) (28|26|13)
- 1:   abnormal granulocyte number [MP:0020201] <6>(4|7) (5|7|1)
- 1:   abnormal lymphocyte cell number [MP:0000717] <5>(13|35) (19|21|12)
- 1:   decreased leukocyte cell number [MP:0000221] <5>(10|22) (14|10|5)
- 1:   increased leukocyte cell number [MP:0000218] <5>(7|19) (10|15|8)
- 1:   abnormal monocyte cell number [MP:0012441] <4>(1|1) (1|1|0)
- 1:   abnormal macrophage cell number [MP:0020202] <2>(4|6) (4|2|0)
- 1:   abnormal plasmacytoid dendritic cell number [MP:0008123] <2>(1|2) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.002888Inherited
Flavoproteins0.003063Inherited
Ran binding protein zinc finger-like0.007919Inherited
Triple coiled coil domain of C-type lectins0.01046Inherited
E2F-DP heterodimerization region0.02197Inherited
Bcl-2 inhibitors of programmed cell death0.02648Inherited
p53-like transcription factors0.05972Inherited
TIMP-like0.07197Inherited
DBL homology domain (DH-domain)0.07819Inherited
Toll/Interleukin receptor TIR domain0.1132Inherited
MHC antigen-recognition domain0.137Inherited
TNF receptor-like0.1551Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2685Inherited
Riboflavin synthase domain-like0.2685Inherited
STAT0.2853Inherited
Transcription factor STAT-4 N-domain0.2853Inherited
Interleukin 8-like chemokines0.3297Inherited
SMAD/FHA domain0.4214Inherited
WWE domain0.4937Inherited
Integrin domains0.5163Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA polymerase beta-like0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Interleukin 17F, IL-17F0Direct
BAFF receptor-like0Direct
DNA polymerase beta-like, second domain0Direct
C1 set domains (antibody constant domain-like)0.0000001614Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0001602Direct
DNA polymerase beta, N-terminal domain-like0.002017Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.002017Inherited
Pointed domain0.002187Inherited
Ran binding protein zinc finger-like0.006081Inherited
E2F dimerization segment0.007309Inherited
Tissue inhibitor of metalloproteinases, TIMP0.007574Inherited
Cytochrome p450 reductase N-terminal domain-like0.007574Inherited
Triple coiled coil domain of C-type lectins0.007574Inherited
Interferon regulatory factor0.01188Inherited
Bcl-2 inhibitors of programmed cell death0.02102Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02331Inherited
NADPH-cytochrome p450 reductase-like0.02331Inherited
Nuclear receptor coactivator interlocking domain0.02331Inherited
SH2 domain0.02957Inherited
Cell cycle transcription factor e2f-dp0.05082Inherited
DBL homology domain (DH-domain)0.06189Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.07741Inherited
Toll/Interleukin receptor TIR domain0.1142Inherited
MHC antigen-recognition domain0.1142Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.1395Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.17Inherited
DEATH domain, DD0.2116Inherited
TNF receptor-like0.2116Inherited
PLC-like (P variant)0.2116Inherited
STAT DNA-binding domain0.2532Inherited
STAT0.2532Inherited
Transcription factor STAT-4 N-domain0.2532Inherited
Interleukin 8-like chemokines0.2976Inherited
Interferons/interleukin-10 (IL-10)0.3074Inherited
Pyrin domain, PYD0.3753Inherited
Short-chain cytokines0.3868Inherited
Pleckstrin-homology domain (PH domain)0.4179Inherited
Interleukin-1 (IL-1)0.4561Inherited
WWE domain0.4561Inherited
V set domains (antibody variable domain-like)0.4708Inherited
Integrin domains0.4814Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.6569Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.001732Inherited
Flavoproteins0.001843Inherited
Ran binding protein zinc finger-like0.005022Inherited
Triple coiled coil domain of C-type lectins0.006761Inherited
E2F-DP heterodimerization region0.0149Inherited
Bcl-2 inhibitors of programmed cell death0.0182Inherited
Nuclear receptor coactivator interlocking domain0.02076Inherited
SH2 domain0.02686Inherited
p53-like transcription factors0.0436Inherited
TIMP-like0.0535Inherited
DBL homology domain (DH-domain)0.05856Inherited
Toll/Interleukin receptor TIR domain0.08808Inherited
MHC antigen-recognition domain0.1088Inherited
TNF receptor-like0.1243Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2286Inherited
Riboflavin synthase domain-like0.2286Inherited
Transcription factor STAT-4 N-domain0.2444Inherited
STAT0.2444Inherited
Interleukin 8-like chemokines0.286Inherited
4-helical cytokines0.2863Inherited
SMAD/FHA domain0.3745Inherited
Integrin alpha N-terminal domain0.3745Inherited
WWE domain0.4464Inherited
Protein kinase-like (PK-like)0.4646Inherited
Integrin domains0.4691Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00002914Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.000431Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.001732Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.001732Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00642Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.006761Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0149Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.02775Inherited
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04225Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.05856Inherited
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0.1426Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.1631Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.166Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2194Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2444Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2444Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2444Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2778Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.2982Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3642Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.3642Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.4464Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.499Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0008184Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001732Inherited
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04225Inherited
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04225Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2033Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2444Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2444Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.4464Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.4464Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.4464Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)