SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): abnormal leukocyte cell number

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <30>
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(64|91) (70|55|28)
+ + + + 4:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(51|75) (61|41|19)
+ + + + 4:   immune system phenotype [MP:0005387] <2>(80|109) (85|61|29)
+ + + 3:   abnormal immune system morphology [MP:0000685] <3>(47|72) (54|35|17)
+ + + 3:   abnormal blood cell morphology/development [MP:0002429] <2>(46|67) (53|37|18)
+ + 2:   abnormal immune system cell morphology [MP:0000716] <5>(39|59) (43|30|16)
+ + 2:   abnormal hematopoiesis [MP:0002123] <8>(46|67) (53|37|18)
+ 1:   abnormal leukocyte morphology [MP:0008246] <4>(39|59) (43|30|16)
+ 1:   abnormal hematopoietic cell number [MP:0011180] <8>(26|49) (32|22|12)
0:   abnormal leukocyte cell number [MP:0000217] <7>(23|45) (28|21|11)
- 1:   abnormal granulocyte number [MP:0020201] <6>(4|7) (5|7|1)
- 1:   abnormal lymphocyte cell number [MP:0000717] <5>(12|32) (17|15|9)
- 1:   decreased leukocyte cell number [MP:0000221] <5>(10|22) (14|9|5)
- 1:   increased leukocyte cell number [MP:0000218] <5>(8|19) (10|13|8)
- 1:   abnormal monocyte cell number [MP:0012441] <4>(1|1) (1|1|0)
- 1:   abnormal macrophage cell number [MP:0020202] <2>(5|9) (6|2|0)
- 1:   abnormal plasmacytoid dendritic cell number [MP:0008123] <2>(1|2) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.002864Inherited
Flavoproteins0.003044Inherited
Ran binding protein zinc finger-like0.007904Inherited
Apolipoprotein A-I0.01042Inherited
Triple coiled coil domain of C-type lectins0.01042Inherited
Bcl-2 inhibitors of programmed cell death0.01538Inherited
E2F-DP heterodimerization region0.02187Inherited
Nuclear receptor coactivator interlocking domain0.02986Inherited
p53-like transcription factors0.06039Inherited
TIMP-like0.07178Inherited
DBL homology domain (DH-domain)0.07857Inherited
Toll/Interleukin receptor TIR domain0.114Inherited
MHC antigen-recognition domain0.114Inherited
TNF receptor-like0.1564Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2692Inherited
Riboflavin synthase domain-like0.2692Inherited
Interleukin 8-like chemokines0.3326Inherited
SMAD/FHA domain0.4241Inherited
WWE domain0.495Inherited
Integrin domains0.518Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
DNA polymerase beta-like0Direct
Interferons/interleukin-10 (IL-10)0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Interleukin 17F, IL-17F0Direct
BAFF receptor-like0Direct
DNA polymerase beta-like, second domain0Direct
C1 set domains (antibody constant domain-like)3.911e-08Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0004447Direct
DNA polymerase beta, N-terminal domain-like0.002005Inherited
Pointed domain0.00218Inherited
Nuclear receptor0.002466Inherited
Nuclear receptor ligand-binding domain0.004256Inherited
Ran binding protein zinc finger-like0.006121Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.007317Inherited
E2F dimerization segment0.007317Inherited
Tissue inhibitor of metalloproteinases, TIMP0.007562Inherited
Apolipoprotein A-I0.007562Inherited
Cytochrome p450 reductase N-terminal domain-like0.007562Inherited
Triple coiled coil domain of C-type lectins0.007562Inherited
Bcl-2 inhibitors of programmed cell death0.01189Inherited
Interferon regulatory factor0.01189Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02313Inherited
NADPH-cytochrome p450 reductase-like0.02313Inherited
Nuclear receptor coactivator interlocking domain0.02313Inherited
SH2 domain0.03064Inherited
Cell cycle transcription factor e2f-dp0.05061Inherited
DBL homology domain (DH-domain)0.06246Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.07725Inherited
MHC antigen-recognition domain0.09388Inherited
Toll/Interleukin receptor TIR domain0.115Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.1406Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.1711Inherited
DEATH domain, DD0.2139Inherited
TNF receptor-like0.2139Inherited
PLC-like (P variant)0.2139Inherited
Interleukin 8-like chemokines0.3003Inherited
Pyrin domain, PYD0.3766Inherited
Short-chain cytokines0.3895Inherited
Pleckstrin-homology domain (PH domain)0.424Inherited
Interleukin-1 (IL-1)0.4577Inherited
WWE domain0.4577Inherited
V set domains (antibody variable domain-like)0.4764Inherited
Integrin domains0.4844Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.6595Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.001746Inherited
Flavoproteins0.00186Inherited
Nuclear receptor ligand-binding domain0.003185Inherited
Ran binding protein zinc finger-like0.005066Inherited
Apolipoprotein A-I0.006793Inherited
Triple coiled coil domain of C-type lectins0.006793Inherited
Bcl-2 inhibitors of programmed cell death0.01026Inherited
E2F-DP heterodimerization region0.01495Inherited
Nuclear receptor coactivator interlocking domain0.02086Inherited
SH2 domain0.02783Inherited
p53-like transcription factors0.04452Inherited
TIMP-like0.05374Inherited
DBL homology domain (DH-domain)0.05933Inherited
MHC antigen-recognition domain0.08911Inherited
Toll/Interleukin receptor TIR domain0.08911Inherited
TNF receptor-like0.1258Inherited
4-helical cytokines0.1681Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2292Inherited
Riboflavin synthase domain-like0.2292Inherited
Interleukin 8-like chemokines0.2889Inherited
SMAD/FHA domain0.3773Inherited
Integrin alpha N-terminal domain0.3773Inherited
WWE domain0.4479Inherited
Integrin domains0.4713Inherited
Protein kinase-like (PK-like)0.4738Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 7.776e-06Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0004368Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.001746Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.006455Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.006793Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.01495Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01495Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.02782Inherited
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04223Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.05933Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.1643Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.222Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2795Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.2997Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3661Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.3661Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.4479Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.5009Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0008317Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.006455Inherited
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04223Inherited
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04223Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2051Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.4479Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.4479Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.4479Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)