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Mammalian Phenotype (MP): abnormal leukocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + 4:   immune system phenotype [MP:0005387] <2>(77|115) (87|66|35)
+ + + 3:   abnormal immune system morphology [MP:0000685] <3>(52|76) (60|35|18)
+ + + 3:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(60|86) (66|47|21)
+ + 2:   abnormal hematopoietic cell morphology [MP:0013656] <9>(51|77) (60|43|18)
+ + 2:   abnormal immune system cell morphology [MP:0000716] <5>(39|63) (48|29|16)
+ 1:   abnormal leukocyte morphology [MP:0008246] <4>(38|62) (47|29|15)
+ 1:   abnormal hematopoietic cell number [MP:0011180] <7>(35|57) (43|29|13)
0:   abnormal leukocyte cell number [MP:0000217] <8>(30|49) (37|25|12)
- 1:   abnormal dendritic cell number [MP:0008125] <7>(2|4) (2|1|0)
- 1:   abnormal granulocyte number [MP:0020201] <6>(3|7) (5|6|2)
- 1:   abnormal lymphocyte cell number [MP:0000717] <6>(19|38) (25|21|9)
- 1:   decreased leukocyte cell number [MP:0000221] <5>(18|28) (24|18|10)
- 1:   increased leukocyte cell number [MP:0000218] <5>(9|23) (15|11|7)
- 1:   abnormal monocyte cell number [MP:0012441] <4>(1|1) (1|1|0)
- 1:   abnormal macrophage cell number [MP:0020202] <2>(5|7) (5|1|0)
- 1:   abnormal plasmacytoid dendritic cell number [MP:0008123] <2>(1|2) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
L30e-like0.001264Inherited
DNA polymerase beta, N-terminal domain-like0.003722Inherited
Flavoproteins0.004087Inherited
Toll/Interleukin receptor TIR domain0.005369Inherited
DEATH domain0.006511Inherited
Ran binding protein zinc finger-like0.01109Inherited
Triple coiled coil domain of C-type lectins0.01276Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01406Inherited
E2F-DP heterodimerization region0.02718Inherited
Bcl-2 inhibitors of programmed cell death0.03339Inherited
p53-like transcription factors0.03959Inherited
TIMP-like0.05733Inherited
SH2 domain0.066Inherited
Cysteine-rich domain0.0861Inherited
TNF receptor-like0.0861Inherited
Integrin domains0.1345Inherited
DBL homology domain (DH-domain)0.1483Inherited
MHC antigen-recognition domain0.1803Inherited
Nuclear receptor ligand-binding domain0.202Inherited
Integrin alpha N-terminal domain0.2406Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3007Inherited
Riboflavin synthase domain-like0.3007Inherited
Calponin-homology domain, CH-domain0.3635Inherited
WWE domain0.5745Inherited
Protein kinase-like (PK-like)0.604Inherited
SMAD/FHA domain0.699Inherited
Terpenoid cyclases/Protein prenyltransferases0.7767Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA polymerase beta-like0Direct
Proteasome subunits0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
BAFF receptor-like0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
C1 set domains (antibody constant domain-like)0.0000003129Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000624Direct
Pyrin domain, PYD0.0001678Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0004848Direct
ets domain0.001057Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001415Inherited
DNA polymerase beta, N-terminal domain-like0.002491Inherited
Interleukin-1 (IL-1)0.002491Inherited
Pointed domain0.002791Inherited
Ran binding protein zinc finger-like0.0082Inherited
Toll/Interleukin receptor TIR domain0.008589Inherited
E2F dimerization segment0.008997Inherited
Tissue inhibitor of metalloproteinases, TIMP0.009074Inherited
Cytochrome p450 reductase N-terminal domain-like0.009074Inherited
Triple coiled coil domain of C-type lectins0.009074Inherited
Interferon regulatory factor0.01466Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.02042Inherited
Bcl-2 inhibitors of programmed cell death0.02551Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02694Inherited
NADPH-cytochrome p450 reductase-like0.02694Inherited
Nuclear receptor coactivator interlocking domain0.02694Inherited
Pleckstrin-homology domain (PH domain)0.03391Inherited
SH2 domain0.05001Inherited
CCCH zinc finger0.05864Inherited
Cell cycle transcription factor e2f-dp0.05942Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.08836Inherited
TNF receptor-like0.1085Inherited
Integrin domains0.1085Inherited
DEATH domain, DD0.1085Inherited
MATH domain0.1185Inherited
PLC-like (P variant)0.1273Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1273Inherited
DBL homology domain (DH-domain)0.1318Inherited
SH3-domain0.1351Inherited
MHC antigen-recognition domain0.1495Inherited
Nuclear receptor0.1699Inherited
Nuclear receptor ligand-binding domain0.1699Inherited
V set domains (antibody variable domain-like)0.2225Inherited
Calponin-homology domain, CH-domain0.3425Inherited
Short-chain cytokines0.4005Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.5014Inherited
WWE domain0.5345Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
L30e-like0.0006954Direct
DNA polymerase beta, N-terminal domain-like0.002178Inherited
Flavoproteins0.002406Inherited
Toll/Interleukin receptor TIR domain0.003227Inherited
DEATH domain0.003963Inherited
Ran binding protein zinc finger-like0.006984Inherited
Triple coiled coil domain of C-type lectins0.008112Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.009012Inherited
NAD kinase/diacylglycerol kinase-like0.009012Inherited
E2F-DP heterodimerization region0.0183Inherited
Bcl-2 inhibitors of programmed cell death0.02289Inherited
Nuclear receptor coactivator interlocking domain0.0247Inherited
p53-like transcription factors0.02745Inherited
TIMP-like0.0411Inherited
SH2 domain0.04804Inherited
beta-beta-alpha zinc fingers0.05151Inherited
CCCH zinc finger0.05333Inherited
Cysteine-rich domain0.06408Inherited
TNF receptor-like0.06408Inherited
Integrin domains0.1052Inherited
DBL homology domain (DH-domain)0.1172Inherited
SH3-domain0.1312Inherited
MHC antigen-recognition domain0.1455Inherited
Nuclear receptor ligand-binding domain0.1653Inherited
Integrin alpha N-terminal domain0.2013Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2578Inherited
Riboflavin synthase domain-like0.2578Inherited
Calponin-homology domain, CH-domain0.318Inherited
WWE domain0.5282Inherited
Protein kinase-like (PK-like)0.5586Inherited
Acyl-CoA N-acyltransferases (Nat)0.657Inherited
SMAD/FHA domain0.6581Inherited
C-type lectin-like0.6593Inherited
Terpenoid cyclases/Protein prenyltransferases0.7404Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00003757Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00004948Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0005626Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0006954Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.002065Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.008112Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0183Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.0183Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.03376Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.05427Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.09077Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1051Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1203Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1711Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1755Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2361Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2361Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2425Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.4486Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.4495Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5248Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001172Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0183Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.03376Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2361Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3144Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5136Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.5282Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5282Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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