SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): abnormal leukocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <30>
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(64|91) (70|56|29)
+ + + + 4:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(51|75) (61|42|20)
+ + + + 4:   immune system phenotype [MP:0005387] <2>(81|110) (86|63|29)
+ + + 3:   abnormal immune system morphology [MP:0000685] <3>(47|72) (53|36|18)
+ + + 3:   abnormal blood cell morphology/development [MP:0002429] <2>(46|67) (53|38|18)
+ + 2:   abnormal immune system cell morphology [MP:0000716] <5>(39|59) (42|31|16)
+ + 2:   abnormal hematopoiesis [MP:0002123] <8>(46|67) (53|38|18)
+ 1:   abnormal leukocyte morphology [MP:0008246] <4>(39|59) (42|31|16)
+ 1:   abnormal hematopoietic cell number [MP:0011180] <8>(24|46) (31|21|11)
0:   abnormal leukocyte cell number [MP:0000217] <7>(21|42) (27|20|10)
- 1:   abnormal granulocyte number [MP:0020201] <6>(4|7) (5|7|1)
- 1:   abnormal lymphocyte cell number [MP:0000717] <5>(11|29) (15|14|8)
- 1:   decreased leukocyte cell number [MP:0000221] <5>(10|22) (13|9|5)
- 1:   increased leukocyte cell number [MP:0000218] <5>(9|19) (11|14|8)
- 1:   abnormal monocyte cell number [MP:0012441] <4>(1|1) (1|1|0)
- 1:   abnormal macrophage cell number [MP:0020202] <2>(5|9) (6|2|0)
- 1:   abnormal plasmacytoid dendritic cell number [MP:0008123] <2>(1|2) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
Flavoproteins0.003011Inherited
Ran binding protein zinc finger-like0.007781Inherited
Apolipoprotein A-I0.01031Inherited
Triple coiled coil domain of C-type lectins0.01031Inherited
E2F-DP heterodimerization region0.02165Inherited
Nuclear receptor coactivator interlocking domain0.02957Inherited
Bcl-2 inhibitors of programmed cell death0.04036Inherited
p53-like transcription factors0.05945Inherited
TIMP-like0.07069Inherited
DBL homology domain (DH-domain)0.07767Inherited
Toll/Interleukin receptor TIR domain0.1131Inherited
MHC antigen-recognition domain0.1131Inherited
TNF receptor-like0.1546Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2671Inherited
Riboflavin synthase domain-like0.2671Inherited
Interleukin 8-like chemokines0.3303Inherited
SMAD/FHA domain0.4219Inherited
WWE domain0.4934Inherited
Integrin domains0.5148Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Interferons/interleukin-10 (IL-10)0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Interleukin 17F, IL-17F0Direct
BAFF receptor-like0Direct
C1 set domains (antibody constant domain-like)3.743e-08Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0004346Direct
Pointed domain0.002148Inherited
Nuclear receptor0.002377Inherited
Nuclear receptor ligand-binding domain0.004108Inherited
Ran binding protein zinc finger-like0.005993Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.007205Inherited
E2F dimerization segment0.007205Inherited
Tissue inhibitor of metalloproteinases, TIMP0.007479Inherited
Apolipoprotein A-I0.007479Inherited
Cytochrome p450 reductase N-terminal domain-like0.007479Inherited
Triple coiled coil domain of C-type lectins0.007479Inherited
Interferon regulatory factor0.0117Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02285Inherited
NADPH-cytochrome p450 reductase-like0.02285Inherited
Nuclear receptor coactivator interlocking domain0.02285Inherited
SH2 domain0.02995Inherited
Bcl-2 inhibitors of programmed cell death0.03265Inherited
Cell cycle transcription factor e2f-dp0.04997Inherited
DBL homology domain (DH-domain)0.06184Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.07643Inherited
MHC antigen-recognition domain0.09299Inherited
Toll/Interleukin receptor TIR domain0.1142Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.1395Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.1701Inherited
DEATH domain, DD0.2122Inherited
TNF receptor-like0.2122Inherited
PLC-like (P variant)0.2122Inherited
Interleukin 8-like chemokines0.2982Inherited
Pyrin domain, PYD0.3751Inherited
Short-chain cytokines0.3872Inherited
Pleckstrin-homology domain (PH domain)0.4207Inherited
Interleukin-1 (IL-1)0.4562Inherited
WWE domain0.4562Inherited
V set domains (antibody variable domain-like)0.4728Inherited
Integrin domains0.4822Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.6572Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
Flavoproteins0.001817Inherited
Nuclear receptor ligand-binding domain0.00305Inherited
Ran binding protein zinc finger-like0.004944Inherited
Apolipoprotein A-I0.006669Inherited
Triple coiled coil domain of C-type lectins0.006669Inherited
E2F-DP heterodimerization region0.01471Inherited
Nuclear receptor coactivator interlocking domain0.02054Inherited
SH2 domain0.027Inherited
Bcl-2 inhibitors of programmed cell death0.02866Inherited
p53-like transcription factors0.04363Inherited
TIMP-like0.05283Inherited
DBL homology domain (DH-domain)0.05849Inherited
MHC antigen-recognition domain0.0882Inherited
Toll/Interleukin receptor TIR domain0.0882Inherited
TNF receptor-like0.1242Inherited
Cysteine-rich domain0.1467Inherited
4-helical cytokines0.1661Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2274Inherited
Riboflavin synthase domain-like0.2274Inherited
Interleukin 8-like chemokines0.2866Inherited
SMAD/FHA domain0.3751Inherited
Integrin alpha N-terminal domain0.3751Inherited
WWE domain0.4463Inherited
Protein kinase-like (PK-like)0.4661Inherited
Integrin domains0.4684Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 7.318e-06Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0004265Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.001708Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.006324Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.006669Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.01471Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01471Inherited
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02054Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.02741Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.05849Inherited
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0.1033Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.163Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2198Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2776Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.2982Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3645Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.3645Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.4463Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.4987Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0008077Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.006324Inherited
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02054Inherited
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02054Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2033Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.4463Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.4463Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.4463Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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