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Mammalian Phenotype (MP): abnormal leukocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|107) (81|66|29)
+ + + + 4:   immune system phenotype [MP:0005387] <2>(79|118) (90|69|34)
+ + + 3:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(59|91) (70|51|20)
+ + + 3:   abnormal immune system morphology [MP:0000685] <3>(52|80) (63|38|17)
+ + 2:   abnormal immune system cell morphology [MP:0000716] <5>(39|66) (50|33|16)
+ + 2:   abnormal hematopoietic cell morphology [MP:0013656] <9>(51|81) (63|46|18)
+ 1:   abnormal leukocyte morphology [MP:0008246] <4>(38|65) (49|33|15)
+ 1:   abnormal hematopoietic cell number [MP:0011180] <7>(32|59) (42|31|13)
0:   abnormal leukocyte cell number [MP:0000217] <8>(28|51) (36|28|12)
- 1:   abnormal dendritic cell number [MP:0008125] <7>(2|4) (2|1|0)
- 1:   abnormal granulocyte number [MP:0020201] <6>(3|9) (6|8|2)
- 1:   abnormal lymphocyte cell number [MP:0000717] <6>(18|36) (23|21|9)
- 1:   decreased leukocyte cell number [MP:0000221] <5>(17|27) (23|18|10)
- 1:   increased leukocyte cell number [MP:0000218] <5>(8|21) (12|13|7)
- 1:   abnormal monocyte cell number [MP:0012441] <4>(1|1) (1|1|0)
- 1:   abnormal macrophage cell number [MP:0020202] <2>(5|8) (5|3|0)
- 1:   abnormal plasmacytoid dendritic cell number [MP:0008123] <2>(1|2) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.003395Inherited
Flavoproteins0.003684Inherited
Toll/Interleukin receptor TIR domain0.00453Inherited
DEATH domain0.006323Inherited
Ran binding protein zinc finger-like0.009783Inherited
Triple coiled coil domain of C-type lectins0.01186Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01269Inherited
E2F-DP heterodimerization region0.02516Inherited
Bcl-2 inhibitors of programmed cell death0.03058Inherited
p53-like transcription factors0.033Inherited
SH2 domain0.06406Inherited
TNF receptor-like0.08441Inherited
Cysteine-rich domain0.08441Inherited
TIMP-like0.09185Inherited
DBL homology domain (DH-domain)0.1181Inherited
Integrin domains0.1324Inherited
Nuclear receptor ligand-binding domain0.1993Inherited
MHC antigen-recognition domain0.2059Inherited
Integrin alpha N-terminal domain0.2385Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2883Inherited
Riboflavin synthase domain-like0.2883Inherited
Calponin-homology domain, CH-domain0.3641Inherited
WWE domain0.5722Inherited
Terpenoid cyclases/Protein prenyltransferases0.7754Inherited
SMAD/FHA domain0.8428Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
BAFF receptor-like0Direct
DNA polymerase beta-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
Proteasome subunits0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00000191Direct
C1 set domains (antibody constant domain-like)0.000002878Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000519Direct
Pyrin domain, PYD0.0001533Direct
ets domain0.0002076Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.00128Inherited
DNA polymerase beta, N-terminal domain-like0.00235Inherited
Interleukin-1 (IL-1)0.00235Inherited
Pointed domain0.002593Inherited
Ran binding protein zinc finger-like0.007481Inherited
Toll/Interleukin receptor TIR domain0.007743Inherited
E2F dimerization segment0.008475Inherited
Triple coiled coil domain of C-type lectins0.008627Inherited
Tissue inhibitor of metalloproteinases, TIMP0.008627Inherited
Cytochrome p450 reductase N-terminal domain-like0.008627Inherited
Interferon regulatory factor0.01372Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.0193Inherited
Bcl-2 inhibitors of programmed cell death0.02398Inherited
Nuclear receptor coactivator interlocking domain0.02568Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02568Inherited
LDH N-terminal domain-like0.02568Inherited
Lactate & malate dehydrogenases, C-terminal domain0.02568Inherited
NADPH-cytochrome p450 reductase-like0.02568Inherited
Pleckstrin-homology domain (PH domain)0.03889Inherited
SH2 domain0.05015Inherited
Cell cycle transcription factor e2f-dp0.05638Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.08461Inherited
DBL homology domain (DH-domain)0.1075Inherited
TNF receptor-like0.1082Inherited
DEATH domain, DD0.1082Inherited
Integrin domains0.1082Inherited
MATH domain0.113Inherited
PLC-like (P variant)0.1272Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1272Inherited
SH3-domain0.1353Inherited
Nuclear receptor ligand-binding domain0.1696Inherited
Nuclear receptor0.1696Inherited
MHC antigen-recognition domain0.1751Inherited
V set domains (antibody variable domain-like)0.2224Inherited
Calponin-homology domain, CH-domain0.3508Inherited
Interferons/interleukin-10 (IL-10)0.3882Inherited
Short-chain cytokines0.3999Inherited
WWE domain0.5334Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.5558Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
DNA polymerase beta, N-terminal domain-like0.00199Inherited
Flavoproteins0.002168Inherited
Toll/Interleukin receptor TIR domain0.002699Inherited
DEATH domain0.003845Inherited
L30e-like0.005729Inherited
Ran binding protein zinc finger-like0.006094Inherited
Triple coiled coil domain of C-type lectins0.007527Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.008082Inherited
E2F-DP heterodimerization region0.01684Inherited
Bcl-2 inhibitors of programmed cell death0.02083Inherited
p53-like transcription factors0.02266Inherited
Nuclear receptor coactivator interlocking domain0.02299Inherited
LDH C-terminal domain-like0.02299Inherited
SH2 domain0.04642Inherited
beta-beta-alpha zinc fingers0.04831Inherited
Cysteine-rich domain0.06277Inherited
TNF receptor-like0.06277Inherited
TIMP-like0.06884Inherited
DBL homology domain (DH-domain)0.09115Inherited
Integrin domains0.1035Inherited
SH3-domain0.128Inherited
Nuclear receptor ligand-binding domain0.1629Inherited
MHC antigen-recognition domain0.1689Inherited
Integrin alpha N-terminal domain0.1991Inherited
Riboflavin synthase domain-like0.2462Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2462Inherited
Calponin-homology domain, CH-domain0.3187Inherited
Protein kinase-like (PK-like)0.406Inherited
Acyl-CoA N-acyltransferases (Nat)0.4221Inherited
WWE domain0.5261Inherited
C-type lectin-like0.6549Inherited
Terpenoid cyclases/Protein prenyltransferases0.7383Inherited
SMAD/FHA domain0.8108Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000001295Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0002385Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0005045Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.000612Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.001827Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.007527Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.01684Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01684Inherited
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0.02299Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.03105Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.03105Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.06876Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.08588Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1042Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1137Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1689Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2337Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2337Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2398Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2769Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.4438Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.4464Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5206Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.7555Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001011Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01684Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.03105Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2337Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3365Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.51Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5261Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.5261Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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