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Mammalian Phenotype (MP): decreased leukocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + 4:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + + 4:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ + + 3:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|76) (60|43|18)
+ + + 3:   abnormal immune system cell morphology [MP:0000716] <5>(37|62) (48|29|16)
+ + 2:   abnormal hematopoietic cell number [MP:0011180] <7>(34|56) (43|29|13)
+ + 2:   abnormal leukocyte morphology [MP:0008246] <4>(36|61) (47|29|15)
+ 1:   decreased hematopoietic cell number [MP:0011182] <5>(21|34) (27|21|11)
+ 1:   abnormal leukocyte cell number [MP:0000217] <8>(29|48) (37|25|12)
0:   decreased leukocyte cell number [MP:0000221] <5>(17|28) (24|18|10)
- 1:   decreased lymphocyte cell number [MP:0005016] <5>(16|28) (22|16|7)
- 1:   decreased granulocyte number [MP:0000334] <4>(0|0) (1|1|1)
- 1:   decreased monocyte cell number [MP:0000223] <2>(0|0) (0|0|0)
- 1:   decreased macrophage cell number [MP:0003884] <1>(0|0) (0|0|0)
- 1:   decreased plasmacytoid dendritic cell number [MP:0008124](1|2) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.001193Inherited
Ran binding protein zinc finger-like0.001971Inherited
Bcl-2 inhibitors of programmed cell death0.006077Inherited
SH2 domain0.007048Inherited
DBL homology domain (DH-domain)0.05673Inherited
Cysteine-rich domain0.07806Inherited
Calponin-homology domain, CH-domain0.221Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2357Inherited
SMAD/FHA domain0.2373Inherited
Integrin alpha N-terminal domain0.2683Inherited
WWE domain0.3847Inherited
E2F-DP heterodimerization region0.3847Inherited
Integrin domains0.4775Inherited
DEATH domain0.5773Inherited
MHC antigen-recognition domain0.7965Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
DNA polymerase beta-like, second domain0Direct
DNA polymerase beta-like0Direct
Proteasome subunits0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000006549Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00004951Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0001954Direct
Pointed domain0.0007107Direct
DNA polymerase beta, N-terminal domain-like0.0007678Direct
Ran binding protein zinc finger-like0.001385Inherited
Bcl-2 inhibitors of programmed cell death0.004321Inherited
Interferon regulatory factor0.004321Inherited
SH2 domain0.00502Inherited
PLC-like (P variant)0.00638Inherited
SH3-domain0.0291Inherited
Pleckstrin-homology domain (PH domain)0.03226Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.0393Inherited
ets domain0.0393Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.04208Inherited
DBL homology domain (DH-domain)0.04816Inherited
Toll/Interleukin receptor TIR domain0.06898Inherited
Calponin-homology domain, CH-domain0.1914Inherited
WWE domain0.3485Inherited
Cell cycle transcription factor e2f-dp0.3485Inherited
E2F dimerization segment0.3485Inherited
C1 set domains (antibody constant domain-like)0.3845Inherited
Integrin domains0.4425Inherited
MHC antigen-recognition domain0.7711Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.000657Direct
Ran binding protein zinc finger-like0.00112Inherited
p53-like transcription factors0.002496Inherited
Bcl-2 inhibitors of programmed cell death0.003681Inherited
SH2 domain0.004321Inherited
SH3-domain0.0263Inherited
DBL homology domain (DH-domain)0.04059Inherited
Toll/Interleukin receptor TIR domain0.04887Inherited
Cysteine-rich domain0.05752Inherited
Protein kinase-like (PK-like)0.1366Inherited
beta-beta-alpha zinc fingers0.1781Inherited
Calponin-homology domain, CH-domain0.1828Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1965Inherited
SMAD/FHA domain0.198Inherited
Integrin alpha N-terminal domain0.2269Inherited
WWE domain0.3384Inherited
E2F-DP heterodimerization region0.3384Inherited
Integrin domains0.4298Inherited
DEATH domain0.531Inherited
Acyl-CoA N-acyltransferases (Nat)0.6147Inherited
MHC antigen-recognition domain0.7615Inherited
C-type lectin-like0.9954Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000001102Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000004759Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0001288Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.002584Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.00628Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.03011Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.07607Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1965Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1965Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2803Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2803Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.3384Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.3384Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.6299Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9699Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000002857Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0001539Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.003217Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.003217Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2803Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3384Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.661Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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