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Mammalian Phenotype (MP): abnormal heart morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   cardiovascular system phenotype [MP:0005385] <2>(67|85) (77|57|35)
+ 1:   abnormal cardiovascular system morphology [MP:0002127] <7>(48|65) (53|44|33)
0:   abnormal heart morphology [MP:0000266] <22>(27|44) (28|25|19)
- 1:   abnormal heart atrium morphology [MP:0003105] <15>(4|4) (4|3|1)
- 1:   abnormal heart ventricle morphology [MP:0005294] <14>(11|22) (13|12|6)
- 1:   abnormal heart development [MP:0000267] <10>(5|11) (6|6|4)
- 1:   abnormal heart valve morphology [MP:0000285] <9>(4|5) (4|3|0)
- 1:   abnormal heart position or orientation [MP:0006065] <7>(0|1) (0|0|0)
- 1:   abnormal pericardium morphology [MP:0000288] <6>(2|3) (2|2|2)
- 1:   abnormal heart atrium and ventricle connection [MP:0010435] <5>(4|5) (4|2|0)
- 1:   abnormal impulse conducting system morphology [MP:0004123] <5>(1|0) (1|0|0)
- 1:   abnormal coronary vessel morphology [MP:0010551] <4>(2|4) (4|0|0)
- 1:   abnormal heart septum morphology [MP:0006113] <4>(5|15) (7|9|3)
- 1:   abnormal heart layer morphology [MP:0010545] <3>(7|13) (8|7|6)
- 1:   abnormal heart size [MP:0005406] <3>(5|10) (5|5|4)
- 1:   dilated heart [MP:0004937] <3>(1|3) (1|3|3)
- 1:   abnormal heart and great vessel attachment [MP:0010425] <2>(2|6) (3|2|0)
- 1:   abnormal heart iron level [MP:0008741] <2>(0|0) (0|0|0)
- 1:   abnormal pericardial cavity morphology [MP:0012501] <2>(2|2) (2|3|3)
- 1:   dystrophic cardiac calcinosis [MP:0002837] <2>(0|0) (0|0|0)
- 1:   abnormal heart apex morphology [MP:0012515] <1>(0|0) (0|0|0)
- 1:   cardiac fibrosis [MP:0003141] <1>(3|1) (3|1|0)
- 1:   abnormal heart shape [MP:0000277](0|0) (0|1|0)
- 1:   absent heart [MP:0011388](0|0) (0|0|0)
- 1:   heart vascular congestion [MP:0010021](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SMAD MH1 domain0Direct
SRF-like0Direct
Notch domain0.001555Inherited
Flavoproteins0.01288Inherited
Glycosyl hydrolase domain0.03814Inherited
p53-like transcription factors0.0545Inherited
Orange domain-like0.06349Inherited
alpha-catenin/vinculin-like0.06349Inherited
Spectrin repeat0.07586Inherited
Blood coagulation inhibitor (disintegrin)0.0807Inherited
Cystine-knot cytokines0.1909Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1975Inherited
Riboflavin synthase domain-like0.2278Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2278Inherited
cAMP-binding domain-like0.2511Inherited
Growth factor receptor domain0.2602Inherited
Clavaminate synthase-like0.2828Inherited
Metalloproteases ("zincins"), catalytic domain0.3364Inherited
Nuclear receptor ligand-binding domain0.4116Inherited
Inhibitor of apoptosis (IAP) repeat0.4344Inherited
Regulator of G-protein signaling, RGS0.5262Inherited
Myosin rod fragments0.7306Inherited
"Winged helix" DNA-binding domain0.8008Inherited
Fibronectin type III0.8026Inherited
HLH, helix-loop-helix DNA-binding domain0.8074Inherited
Cytokine0.8141Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
SMAD MH1 domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
SMAD domain0Direct
SRF-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
L domain0.00004729Direct
DIX domain0.0002302Direct
Notch domain0.001059Inherited
NADPH-cytochrome p450 reductase-like0.001059Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001059Inherited
ZZ domain0.002838Inherited
Erythroid transcription factor GATA-10.002838Inherited
Ras-binding domain, RBD0.002907Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.009722Inherited
Histone deacetylase, HDAC0.01107Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01107Inherited
alpha-catenin/vinculin0.01473Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.01621Inherited
LIM domain0.03582Inherited
Hairy Orange domain0.05178Inherited
Spectrin repeat0.05879Inherited
DEP domain0.06487Inherited
Blood coagulation inhibitor (disintegrin)0.06978Inherited
Protein kinases, catalytic subunit0.07778Inherited
Growth factor receptor domain0.08383Inherited
T-box0.09588Inherited
Linker histone H1/H50.1082Inherited
Cyclin0.2466Inherited
Platelet-derived growth factor-like0.2466Inherited
Transforming growth factor (TGF)-beta0.32Inherited
HMG-box0.32Inherited
Forkhead DNA-binding domain0.3755Inherited
Nuclear receptor ligand-binding domain0.3756Inherited
Nuclear receptor0.3756Inherited
EGF-type module0.3951Inherited
Inhibitor of apoptosis (IAP) repeat0.3954Inherited
Extracellular domain of cell surface receptors0.4222Inherited
Reprolysin-like0.4222Inherited
Fibroblast growth factors (FGF)0.4222Inherited
Regulator of G-protein signaling, RGS0.4893Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.4984Inherited
Myosin rod fragments0.6997Inherited
Fibronectin type III0.7776Inherited
HLH, helix-loop-helix DNA-binding domain0.7827Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SRF-like0Direct
SMAD MH1 domain0Direct
Notch domain0.0008717Direct
Flavoproteins0.008187Inherited
Glycosyl hydrolase domain0.02637Inherited
p53-like transcription factors0.0388Inherited
alpha-catenin/vinculin-like0.046Inherited
Orange domain-like0.046Inherited
Spectrin repeat0.05583Inherited
Blood coagulation inhibitor (disintegrin)0.0596Inherited
Cystine-knot cytokines0.155Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.161Inherited
Riboflavin synthase domain-like0.1891Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1891Inherited
cAMP-binding domain-like0.2109Inherited
Growth factor receptor domain0.2191Inherited
Clavaminate synthase-like0.2406Inherited
Metalloproteases ("zincins"), catalytic domain0.2913Inherited
HMG-box0.3106Inherited
Nuclear receptor ligand-binding domain0.3647Inherited
Inhibitor of apoptosis (IAP) repeat0.3871Inherited
Regulator of G-protein signaling, RGS0.4789Inherited
Myosin rod fragments0.6916Inherited
"Winged helix" DNA-binding domain0.766Inherited
Fibronectin type III0.7679Inherited
HLH, helix-loop-helix DNA-binding domain0.7731Inherited
Cytokine0.7802Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00003534Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00003534Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.008187Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.009166Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01269Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01269Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.02496Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.02637Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03296Inherited
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.046Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.046Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.0596Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.09167Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1647Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1926Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1999Inherited
    49854,49854
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0.2396Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.2396Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.2396Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2406Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.3463Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.654Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.7106Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00003534Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0008305Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001724Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.005433Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.008187Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01269Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01269Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01571Inherited
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.02678Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1488Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1488Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.3048Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.3048Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3048Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4129Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.7802Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.838Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)