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Mammalian Phenotype (MP): abnormal craniofacial morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   craniofacial phenotype [MP:0005382] <1>(21|36) (25|18|10)
0:   abnormal craniofacial morphology [MP:0000428] <5>(21|36) (25|18|10)
- 1:   abnormal outer ear morphology [MP:0002177] <19>(0|0) (1|1|0)
- 1:   abnormal craniofacial development [MP:0003935] <17>(4|3) (5|3|2)
- 1:   abnormal facial morphology [MP:0003743] <10>(8|18) (8|3|2)
- 1:   abnormal head shape [MP:0011495] <7>(1|0) (1|0|0)
- 1:   abnormal craniofacial bone morphology [MP:0002116] <3>(16|25) (17|14|7)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Homeodomain-like0Direct
SMAD MH1 domain0.000002409Direct
p53-like transcription factors0.00001127Direct
Growth factor receptor domain0.0001017Direct
Cystine-knot cytokines0.0001197Direct
EGF/Laminin0.001148Inherited
FnI-like domain0.004879Inherited
Intermediate filament protein, coiled coil region0.005473Inherited
TB module/8-cys domain0.01032Inherited
Bromodomain0.03482Inherited
Metalloproteases ("zincins"), catalytic domain0.04208Inherited
PGBD-like0.07048Inherited
Snake toxin-like0.07906Inherited
Nuclear receptor ligand-binding domain0.08869Inherited
Hemopexin-like domain0.1166Inherited
lambda repressor-like DNA-binding domains0.1724Inherited
(Trans)glycosidases0.1745Inherited
Transducin (alpha subunit), insertion domain0.2319Inherited
4-helical cytokines0.2879Inherited
Family A G protein-coupled receptor-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
p53 DNA-binding domain-like0Direct
Homeodomain0.000000000000007865Direct
SMAD domain0.000001607Direct
SMAD MH1 domain0.000001607Direct
Paired domain0.00001063Direct
Forkhead DNA-binding domain0.0001284Direct
T-box0.0007988Direct
Arylsulfatase0.0009278Direct
CalX-beta domain0.0009278Direct
Transforming growth factor (TGF)-beta0.0009285Direct
Growth factor receptor domain0.001062Inherited
Multidrug efflux transporter AcrB transmembrane domain0.002176Inherited
TNF receptor-like0.002618Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.003979Inherited
Intermediate filament protein, coiled coil region0.004748Inherited
Laminin-type module0.005769Inherited
TB module/8-cys domain0.007928Inherited
Pyridoxal-dependent decarboxylase0.01544Inherited
VWC domain0.01562Inherited
Extracellular domain of cell surface receptors0.02115Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.02197Inherited
Neutral endopeptidase (neprilysin)0.02689Inherited
Ephrin ectodomain0.02689Inherited
Bromodomain0.03016Inherited
MMP N-terminal domain0.06098Inherited
I set domains0.06605Inherited
Nuclear receptor0.06616Inherited
Matrix metalloproteases, catalytic domain0.07424Inherited
Nuclear receptor ligand-binding domain0.0827Inherited
Hemopexin-like domain0.1045Inherited
DEATH domain, DD0.1292Inherited
Transducin (alpha subunit), insertion domain0.2127Inherited
G proteins0.3519Inherited
Rhodopsin-like1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Homeodomain-like0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0.000001016Direct
p53-like transcription factors0.000005016Direct
Growth factor receptor domain0.00004988Direct
Cystine-knot cytokines0.00005894Direct
EGF/Laminin0.0006328Direct
CalX-like0.00072Direct
Protein kinase-like (PK-like)0.0007766Direct
FnI-like domain0.002926Inherited
Intermediate filament protein, coiled coil region0.003303Inherited
TB module/8-cys domain0.006475Inherited
Alkaline phosphatase-like0.008981Inherited
Orange domain-like0.02326Inherited
Bromodomain0.02395Inherited
Metalloproteases ("zincins"), catalytic domain0.02929Inherited
PGBD-like0.05158Inherited
Snake toxin-like0.05849Inherited
Nuclear receptor ligand-binding domain0.06627Inherited
Hemopexin-like domain0.08988Inherited
lambda repressor-like DNA-binding domains0.1384Inherited
(Trans)glycosidases0.1404Inherited
Transducin (alpha subunit), insertion domain0.193Inherited
4-helical cytokines0.2457Inherited
Family A G protein-coupled receptor-like1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0004817Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.000577Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.001261Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.001495Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.001792Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.003133Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.003219Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.008565Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.01303Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.01303Inherited
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0.01303Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.02326Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0342Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.05158Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.07573Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.193Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2544Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00008014Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0005501Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.001261Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.002578Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.003219Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.006034Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.006034Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.01303Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02326Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.02355Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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