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Mammalian Phenotype (MP): abnormal craniofacial morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   craniofacial phenotype [MP:0005382] <1>(20|36) (24|18|10)
0:   abnormal craniofacial morphology [MP:0000428] <5>(20|36) (24|18|10)
- 1:   abnormal outer ear morphology [MP:0002177] <19>(0|1) (1|1|0)
- 1:   abnormal craniofacial development [MP:0003935] <17>(3|3) (5|3|2)
- 1:   abnormal facial morphology [MP:0003743] <10>(8|18) (8|3|2)
- 1:   abnormal head shape [MP:0011495] <7>(1|0) (1|0|0)
- 1:   abnormal craniofacial bone morphology [MP:0002116] <3>(16|25) (16|13|7)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Homeodomain-like0Direct
SMAD MH1 domain0.000002294Direct
p53-like transcription factors0.00001004Direct
Growth factor receptor domain0.00003975Direct
Cystine-knot cytokines0.0001069Direct
EGF/Laminin0.000633Direct
FnI-like domain0.004647Inherited
Intermediate filament protein, coiled coil region0.005156Inherited
TB module/8-cys domain0.01007Inherited
Bromodomain0.03359Inherited
Metalloproteases ("zincins"), catalytic domain0.03963Inherited
PGBD-like0.06884Inherited
Nuclear receptor ligand-binding domain0.08592Inherited
Hemopexin-like domain0.1145Inherited
lambda repressor-like DNA-binding domains0.169Inherited
(Trans)glycosidases0.1884Inherited
Transducin (alpha subunit), insertion domain0.2288Inherited
4-helical cytokines0.3231Inherited
Family A G protein-coupled receptor-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Homeodomain0.000000000000007882Direct
SMAD domain0.000001517Direct
SMAD MH1 domain0.000001517Direct
Paired domain0.00001016Direct
Forkhead DNA-binding domain0.00017Direct
Growth factor receptor domain0.0004164Direct
T-box0.0007616Direct
Transforming growth factor (TGF)-beta0.0008673Direct
CalX-beta domain0.0008979Direct
Arylsulfatase0.002009Inherited
Multidrug efflux transporter AcrB transmembrane domain0.002125Inherited
TNF receptor-like0.002513Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.003861Inherited
Intermediate filament protein, coiled coil region0.004496Inherited
Laminin-type module0.00556Inherited
TB module/8-cys domain0.007739Inherited
Pyridoxal-dependent decarboxylase0.01519Inherited
VWC domain0.01524Inherited
Extracellular domain of cell surface receptors0.02073Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.02142Inherited
Neutral endopeptidase (neprilysin)0.02659Inherited
Ephrin ectodomain0.02659Inherited
Bromodomain0.02925Inherited
MMP N-terminal domain0.05985Inherited
Nuclear receptor0.06417Inherited
I set domains0.06794Inherited
Matrix metalloproteases, catalytic domain0.07297Inherited
Nuclear receptor ligand-binding domain0.08025Inherited
Hemopexin-like domain0.1031Inherited
DEATH domain, DD0.1268Inherited
Transducin (alpha subunit), insertion domain0.2112Inherited
G proteins0.4125Inherited
Rhodopsin-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Homeodomain-like0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0.000000947Direct
p53-like transcription factors0.000004378Direct
Growth factor receptor domain0.00001832Direct
Cystine-knot cytokines0.00005167Direct
EGF/Laminin0.0003359Direct
CalX-like0.0006907Direct
Protein kinase-like (PK-like)0.0008276Direct
FnI-like domain0.002763Inherited
Intermediate filament protein, coiled coil region0.003089Inherited
TB module/8-cys domain0.006291Inherited
Orange domain-like0.02286Inherited
Bromodomain0.02305Inherited
Metalloproteases ("zincins"), catalytic domain0.02749Inherited
PGBD-like0.05032Inherited
Nuclear receptor ligand-binding domain0.06394Inherited
Snake toxin-like0.0658Inherited
Hemopexin-like domain0.08797Inherited
lambda repressor-like DNA-binding domains0.1354Inherited
(Trans)glycosidases0.1528Inherited
Transducin (alpha subunit), insertion domain0.1903Inherited
4-helical cytokines0.2792Inherited
Family A G protein-coupled receptor-like1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0004309Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0004594Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0005445Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.001221Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.001742Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.003035Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.00313Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.008295Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.01279Inherited
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0.01279Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.01279Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.02286Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0331Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.05032Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.07416Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1903Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2479Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00007529Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0003676Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0005626Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.001221Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00313Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.005902Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.005902Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.01279Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.02277Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0357Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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