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Mammalian Phenotype (MP): abnormal lymphocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + + 4:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ + + 3:   abnormal immune system cell morphology [MP:0000716] <5>(37|62) (48|29|16)
+ + + 3:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|76) (60|43|18)
+ + 2:   abnormal mononuclear cell morphology [MP:0008247] <2>(33|56) (41|28|14)
+ + 2:   abnormal hematopoietic cell number [MP:0011180] <7>(34|56) (43|29|13)
+ + 2:   abnormal leukocyte morphology [MP:0008246] <4>(36|61) (47|29|15)
+ 1:   abnormal leukocyte cell number [MP:0000217] <8>(29|48) (37|25|12)
+ 1:   abnormal lymphocyte morphology [MP:0002619] <5>(27|45) (33|26|14)
0:   abnormal lymphocyte cell number [MP:0000717] <6>(18|37) (25|21|9)
- 1:   abnormal T cell number [MP:0006387] <11>(8|22) (16|15|7)
- 1:   abnormal B cell number [MP:0002458] <6>(7|17) (8|8|4)
- 1:   abnormal NK cell number [MP:0008043] <6>(0|0) (0|0|0)
- 1:   decreased lymphocyte cell number [MP:0005016] <5>(16|28) (22|16|7)
- 1:   increased lymphocyte cell number [MP:0005013] <4>(3|11) (8|6|6)
- 1:   abnormal T cell compartment [MP:0013887] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
TNF receptor-like0.000000000243Direct
DNA polymerase beta, N-terminal domain-like0.001133Inherited
SH2 domain0.003808Inherited
Bcl-2 inhibitors of programmed cell death0.005767Inherited
E2F-DP heterodimerization region0.009728Inherited
DEATH domain0.01172Inherited
WWE domain0.05207Inherited
MHC antigen-recognition domain0.08364Inherited
Integrin alpha N-terminal domain0.1332Inherited
Ran binding protein zinc finger-like0.1676Inherited
Cysteine-rich domain0.2036Inherited
Toll/Interleukin receptor TIR domain0.2578Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2633Inherited
DBL homology domain (DH-domain)0.374Inherited
Calponin-homology domain, CH-domain0.5597Inherited
Integrin domains0.5947Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
DNA polymerase beta-like, second domain0Direct
Interleukin 17F, IL-17F0Direct
BAFF receptor-like0Direct
DNA polymerase beta-like0Direct
Proteasome subunits0Direct
TNF receptor-like0.000000006618Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000006285Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000475Direct
DEATH domain, DD0.0001675Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0001881Direct
Pointed domain0.0006915Direct
DNA polymerase beta, N-terminal domain-like0.0007538Direct
E2F dimerization segment0.002941Inherited
SH2 domain0.003388Inherited
Bcl-2 inhibitors of programmed cell death0.004224Inherited
Interferon regulatory factor0.004224Inherited
SH3-domain0.005955Inherited
PLC-like (P variant)0.006146Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.007174Inherited
Nuclear receptor coactivator interlocking domain0.01157Inherited
Cell cycle transcription factor e2f-dp0.02322Inherited
WWE domain0.02415Inherited
C1 set domains (antibody constant domain-like)0.02538Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.04152Inherited
MATH domain0.05055Inherited
MHC antigen-recognition domain0.07042Inherited
Pleckstrin-homology domain (PH domain)0.07099Inherited
Ran binding protein zinc finger-like0.1468Inherited
ets domain0.1957Inherited
V set domains (antibody variable domain-like)0.2479Inherited
Toll/Interleukin receptor TIR domain0.2851Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.3432Inherited
DBL homology domain (DH-domain)0.3551Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3551Inherited
Calponin-homology domain, CH-domain0.5397Inherited
Integrin domains0.5785Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
TNF receptor-like0.00000000008894Direct
DNA polymerase beta, N-terminal domain-like0.0006227Direct
SH2 domain0.002237Inherited
Bcl-2 inhibitors of programmed cell death0.00348Inherited
SH3-domain0.003539Inherited
E2F-DP heterodimerization region0.006071Inherited
DEATH domain0.007423Inherited
Nuclear receptor coactivator interlocking domain0.01Inherited
p53-like transcription factors0.01924Inherited
WWE domain0.03688Inherited
beta-beta-alpha zinc fingers0.04887Inherited
MHC antigen-recognition domain0.06201Inherited
Integrin alpha N-terminal domain0.104Inherited
Ran binding protein zinc finger-like0.1341Inherited
Cysteine-rich domain0.1666Inherited
Toll/Interleukin receptor TIR domain0.217Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2221Inherited
CCCH zinc finger0.2859Inherited
DBL homology domain (DH-domain)0.3281Inherited
Acyl-CoA N-acyltransferases (Nat)0.4088Inherited
Protein kinase-like (PK-like)0.4376Inherited
Calponin-homology domain, CH-domain0.5131Inherited
Integrin domains0.549Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0000001292Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000004276Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0001193Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0001193Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0003874Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.006071Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.006071Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.02008Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.02681Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.04882Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.05653Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.06201Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.1341Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.1341Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.2859Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3281Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.3674Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.006071Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.1341Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.3674Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3674Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3674Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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