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Mammalian Phenotype (MP): abnormal skeleton physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
0:   abnormal skeleton physiology [MP:0001533] <12>(17|20) (18|12|6)
- 1:   abnormal bone ossification [MP:0008271] <10>(8|11) (8|1|2)
- 1:   abnormal bone strength [MP:0001542] <5>(0|0) (0|0|0)
- 1:   abnormal bone remodeling [MP:0002998] <4>(3|6) (4|4|3)
- 1:   joint inflammation [MP:0002933] <4>(6|6) (6|5|0)
- 1:   abnormal bone stiffness [MP:0013636] <2>(0|1) (0|0|0)
- 1:   abnormal chondrocyte physiology [MP:0009780] <2>(0|0) (0|0|0)
- 1:   abnormal tendon stiffness [MP:0003097] <1>(1|1) (1|0|0)
- 1:   abnormal bone healing [MP:0002999](0|0) (0|0|0)
- 1:   abnormal joint mobility [MP:0008069](0|0) (0|0|0)
- 1:   bone necrosis [MP:0020225](0|0) (0|0|0)
- 1:   enthesitis [MP:0013942](0|0) (0|0|0)
- 1:   osteomyelitis [MP:0005190](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Integrin beta tail domain0.0007649Direct
Kringle-like0.001341Inherited
TNF-like0.001926Inherited
Riboflavin synthase domain-like0.006919Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.006919Inherited
Flavoproteins0.008302Inherited
PGBD-like0.01497Inherited
Metalloproteases ("zincins"), catalytic domain0.01568Inherited
Leucine zipper domain0.01778Inherited
Spermadhesin, CUB domain0.01893Inherited
Hemopexin-like domain0.03495Inherited
Toll/Interleukin receptor TIR domain0.08761Inherited
TB module/8-cys domain0.1229Inherited
FnI-like domain0.1331Inherited
L domain-like0.2234Inherited
Growth factor receptor domain0.2925Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Cytochrome p450 reductase N-terminal domain-like0.0003792Direct
Integrin beta tail domain0.0004939Direct
TNF-like0.001211Inherited
NADPH-cytochrome p450 reductase-like0.001366Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001366Inherited
MMP N-terminal domain0.01046Inherited
Matrix metalloproteases, catalytic domain0.01046Inherited
Leucine zipper domain0.01272Inherited
Spermadhesin, CUB domain0.01345Inherited
Hemopexin-like domain0.02552Inherited
EGF-type module0.04046Inherited
Toll/Interleukin receptor TIR domain0.06402Inherited
Extracellular domain of cell surface receptors0.09694Inherited
TB module/8-cys domain0.09935Inherited
TNF receptor-like0.1574Inherited
Transforming growth factor (TGF)-beta0.1712Inherited
Ngr ectodomain-like0.2459Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Integrin beta tail domain0.0004117Direct
Kringle-like0.0007461Direct
TNF-like0.001092Inherited
Riboflavin synthase domain-like0.004232Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.004232Inherited
Flavoproteins0.005127Inherited
PGBD-like0.00961Inherited
Metalloproteases ("zincins"), catalytic domain0.0101Inherited
Leucine zipper domain0.01159Inherited
Spermadhesin, CUB domain0.01235Inherited
Hemopexin-like domain0.02405Inherited
Toll/Interleukin receptor TIR domain0.06531Inherited
TB module/8-cys domain0.09499Inherited
FnI-like domain0.1039Inherited
TNF receptor-like0.1514Inherited
L domain-like0.185Inherited
Growth factor receptor domain0.2498Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0004117Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0004117Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0008811Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.008477Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.00961Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.01479Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01809Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.03573Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.03573Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.03573Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1704Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0004117Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03573Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.03573Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.09499Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2604Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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