SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal cardiovascular system physiology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   cardiovascular system phenotype [MP:0005385] <2>(67|85) (77|57|35)
0:   abnormal cardiovascular system physiology [MP:0001544] <24>(39|45) (46|26|17)
- 1:   abnormal blood circulation [MP:0002128] <13>(17|22) (20|10|6)
- 1:   abnormal blood vessel physiology [MP:0000249] <11>(13|17) (15|5|3)
- 1:   abnormal impulse conducting system conduction [MP:0003137] <6>(4|4) (6|3|2)
- 1:   altered response to myocardial infarction [MP:0000343] <6>(0|0) (0|0|0)
- 1:   abnormal myocardial fiber physiology [MP:0004215] <5>(0|1) (1|0|0)
- 1:   abnormal heartbeat [MP:0004085] <4>(9|9) (11|5|1)
- 1:   abnormal systemic arterial blood pressure [MP:0000230] <3>(8|8) (10|2|0)
- 1:   heart inflammation [MP:0001853] <3>(0|0) (0|0|0)
- 1:   abnormal cardiac muscle contractility [MP:0002972] <2>(6|8) (7|3|3)
- 1:   abnormal cardiac valve physiology [MP:0011926] <2>(1|1) (1|0|0)
- 1:   abnormal fetal cardiomyocyte physiology [MP:0011390] <2>(0|1) (0|0|0)
- 1:   abnormal heart ventricle pressure [MP:0008775] <2>(4|4) (4|1|1)
- 1:   abnormal mean heart rate adaptation [MP:0020095] <2>(0|0) (0|0|0)
- 1:   abnormal pulmonary pressure [MP:0003547] <2>(0|0) (0|0|0)
- 1:   abnormal susceptibility to aortic cartilaginous metaplasia [MP:0020092] <2>(0|0) (0|0|0)
- 1:   abnormal susceptibility to diet-induced aortic fatty streak lesions [MP:0020098] <2>(0|0) (0|0|0)
- 1:   altered response of heart to induced stress [MP:0004484] <2>(0|0) (0|0|0)
- 1:   cardiomyopathy [MP:0005330] <2>(1|2) (1|5|3)
- 1:   abnormal blood pressure regulation [MP:0010695] <1>(0|0) (0|0|0)
- 1:   abnormal cardiac cell glucose uptake [MP:0004039](0|0) (0|0|0)
- 1:   abnormal cardiac muscle relaxation [MP:0004084](0|0) (0|0|0)
- 1:   abnormal heart echocardiography feature [MP:0011925](0|0) (0|0|0)
- 1:   congestive heart failure [MP:0006138](3|5) (3|1|1)
- 1:   portal hypertension [MP:0003328](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
SRF-like0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Family A G protein-coupled receptor-like0.000008051Direct
GLA-domain0.00005618Direct
Riboflavin synthase domain-like0.001741Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.001741Inherited
Voltage-gated potassium channels0.007605Inherited
FnI-like domain0.009076Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.0101Inherited
p53-like transcription factors0.01525Inherited
alpha-catenin/vinculin-like0.02085Inherited
Inhibitor of apoptosis (IAP) repeat0.02085Inherited
Flavoproteins0.02085Inherited
ACT-like0.02889Inherited
Toll/Interleukin receptor TIR domain0.06363Inherited
cAMP-binding domain-like0.1009Inherited
Transducin (alpha subunit), insertion domain0.1071Inherited
Nucleotide cyclase0.1428Inherited
Kringle-like0.1628Inherited
Glycosyl hydrolase domain0.1902Inherited
Cytochrome P4500.2Inherited
C-type lectin-like0.2245Inherited
EGF/Laminin0.2877Inherited
SMAD/FHA domain0.2995Inherited
PLP-dependent transferases0.3166Inherited
SMAD MH1 domain0.3189Inherited
YWTD domain0.394Inherited
Nuclear receptor ligand-binding domain0.4168Inherited
Growth factor receptor domain0.4258Inherited
Snake toxin-like0.4383Inherited
WW domain0.4383Inherited
PYP-like sensor domain (PAS domain)0.5063Inherited
Spectrin repeat0.5063Inherited
Trypsin-like serine proteases0.5115Inherited
Metalloproteases ("zincins"), catalytic domain0.7221Inherited
PGBD-like0.9019Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
SRF-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
p53 tetramerization domain0Direct
Rhodopsin-like0.00003629Direct
GLA-domain0.0000441Direct
L domain0.000125Direct
VWC domain0.0001342Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0003329Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0005606Direct
Cell cycle transcription factor e2f-dp0.001853Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.002044Inherited
NADPH-cytochrome p450 reductase-like0.002044Inherited
Histone deacetylase, HDAC0.004261Inherited
Inhibitor of apoptosis (IAP) repeat0.007479Inherited
Phenylalanine metabolism regulatory domain0.007794Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.007794Inherited
Anion transport protein, cytoplasmic domain0.01201Inherited
alpha-catenin/vinculin0.02351Inherited
Transducin (alpha subunit), insertion domain0.0946Inherited
Toll/Interleukin receptor TIR domain0.1055Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1275Inherited
Erythroid transcription factor GATA-10.1719Inherited
Cytochrome P4500.1896Inherited
LIM domain0.2197Inherited
Pointed domain0.2311Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.2407Inherited
Eukaryotic proteases0.2975Inherited
SMAD domain0.3029Inherited
SMAD MH1 domain0.3029Inherited
YWTD domain0.3772Inherited
Kringle modules0.3772Inherited
Nuclear receptor ligand-binding domain0.4258Inherited
Nuclear receptor0.4258Inherited
WW domain0.431Inherited
Growth factor receptor domain0.4316Inherited
Forkhead DNA-binding domain0.4545Inherited
Spectrin repeat0.5002Inherited
C-type lectin domain0.8128Inherited
Phosphotyrosine-binding domain (PTB)0.8216Inherited
Matrix metalloproteases, catalytic domain0.8407Inherited
MMP N-terminal domain0.8977Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SRF-like0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Family A G protein-coupled receptor-like0.000003498Direct
GLA-domain0.00002644Direct
Riboflavin synthase domain-like0.0009836Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0009836Direct
Voltage-gated potassium channels0.004666Inherited
FnI-like domain0.005623Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.006312Inherited
p53-like transcription factors0.009804Inherited
Arginase/deacetylase0.01062Inherited
Flavoproteins0.01372Inherited
alpha-catenin/vinculin-like0.01372Inherited
Inhibitor of apoptosis (IAP) repeat0.01372Inherited
Phoshotransferase/anion transport protein0.01658Inherited
ACT-like0.01955Inherited
Toll/Interleukin receptor TIR domain0.04613Inherited
dsRNA-binding domain-like0.06415Inherited
cAMP-binding domain-like0.07625Inherited
Calponin-homology domain, CH-domain0.08112Inherited
Transducin (alpha subunit), insertion domain0.08153Inherited
Nucleotide cyclase0.1124Inherited
Kringle-like0.1299Inherited
Glycosyl hydrolase domain0.1543Inherited
Cytochrome P4500.1633Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1676Inherited
C-type lectin-like0.1861Inherited
Blood coagulation inhibitor (disintegrin)0.2074Inherited
EGF/Laminin0.2452Inherited
SMAD/FHA domain0.2562Inherited
PLP-dependent transferases0.2725Inherited
SMAD MH1 domain0.2748Inherited
YWTD domain0.3474Inherited
Nuclear receptor ligand-binding domain0.3697Inherited
Growth factor receptor domain0.3792Inherited
WW domain0.3908Inherited
Snake toxin-like0.3908Inherited
PYP-like sensor domain (PAS domain)0.4588Inherited
Spectrin repeat0.4588Inherited
Trypsin-like serine proteases0.4641Inherited
Tudor/PWWP/MBT0.6745Inherited
Metalloproteases ("zincins"), catalytic domain0.6825Inherited
PGBD-like0.8752Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0000185Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00008587Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00008587Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000386Direct
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.000444Direct
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.001651Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.004432Inherited
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0.006312Inherited
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.01372Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01955Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01955Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08153Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.09942Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1362Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1543Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.2074Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2154Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.4013Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.6616Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.673Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.8752Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00008587Direct
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.0003793Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.001571Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.001571Inherited
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.005884Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01955Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01955Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.08153Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.09942Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.09977Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2154Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.2885Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.2885Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.4363Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)