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Mammalian Phenotype (MP): abnormal hematopoietic system physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
0:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
- 1:   abnormal thymus physiology [MP:0003763] <4>(1|2) (1|1|0)
- 1:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
- 1:   abnormal hematopoietic stem cell physiology [MP:0010763] <2>(0|0) (0|0|0)
- 1:   abnormal splenocyte physiology [MP:0009333] <2>(1|2) (1|0|0)
- 1:   abnormal bone marrow cell physiology [MP:0009278] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
Immunoglobulin0.0000003435Direct
DEATH domain0.000002272Direct
SH2 domain0.00001743Direct
Toll/Interleukin receptor TIR domain0.00008424Direct
Caspase-like0.00008601Direct
p53-like transcription factors0.000376Direct
Inhibitor of apoptosis (IAP) repeat0.003619Inherited
SH3-domain0.004121Inherited
TNF receptor-like0.01202Inherited
Integrin alpha N-terminal domain0.01346Inherited
TNF-like0.01367Inherited
PH domain-like0.01598Inherited
Integrin domains0.0258Inherited
Family A G protein-coupled receptor-like0.02719Inherited
Bcl-2 inhibitors of programmed cell death0.0349Inherited
DBL homology domain (DH-domain)0.04336Inherited
C-type lectin-like0.05222Inherited
Cysteine-rich domain0.0647Inherited
MHC antigen-recognition domain0.07252Inherited
4-helical cytokines0.09106Inherited
A DNA-binding domain in eukaryotic transcription factors0.1021Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1328Inherited
SMAD/FHA domain0.1517Inherited
Interleukin 8-like chemokines0.1739Inherited
vWA-like0.189Inherited
E set domains0.1894Inherited
WWE domain0.1968Inherited
PLC-like phosphodiesterases0.2045Inherited
Transducin (alpha subunit), insertion domain0.2594Inherited
Integrin beta tail domain0.283Inherited
Complement control module/SCR domain0.367Inherited
Flavoproteins0.3888Inherited
L30e-like0.5623Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5873Inherited
EGF/Laminin0.6869Inherited
L domain-like0.862Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cysteine rich domain0Direct
Proteasome subunits0Direct
Transcription factor STAT-4 N-domain0Direct
STAT DNA-binding domain0Direct
SH2 domain0.00001692Direct
Caspase recruitment domain, CARD0.00004403Direct
Toll/Interleukin receptor TIR domain0.0001034Direct
Caspase catalytic domain0.0002123Direct
Inhibitor of apoptosis (IAP) repeat0.0006222Direct
Interferon regulatory factor0.002273Inherited
Pleckstrin-homology domain (PH domain)0.002316Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.002646Inherited
DEATH domain, DD0.002963Inherited
SH3-domain0.004091Inherited
C-type lectin domain0.004768Inherited
V set domains (antibody variable domain-like)0.004768Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.006569Inherited
TNF receptor-like0.007315Inherited
Cytochrome p450 reductase N-terminal domain-like0.008785Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01073Inherited
TNF-like0.01129Inherited
Integrin alpha N-terminal domain0.01177Inherited
Rhodopsin-like0.0137Inherited
PLC-like (P variant)0.01631Inherited
Short-chain cytokines0.01737Inherited
I set domains0.01848Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01966Inherited
Integrin domains0.0213Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02612Inherited
NADPH-cytochrome p450 reductase-like0.02612Inherited
Bcl-2 inhibitors of programmed cell death0.02768Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.03963Inherited
DBL homology domain (DH-domain)0.04026Inherited
Pyrin domain, PYD0.04429Inherited
C1 set domains (antibody constant domain-like)0.04663Inherited
MHC antigen-recognition domain0.06358Inherited
Mammalian PLC0.07046Inherited
A DNA-binding domain in eukaryotic transcription factors0.08732Inherited
28-residue LRR0.09128Inherited
Integrin A (or I) domain0.1276Inherited
Interleukin 8-like chemokines0.161Inherited
ets domain0.1634Inherited
WWE domain0.1727Inherited
Transducin (alpha subunit), insertion domain0.2373Inherited
Integrin beta EGF-like domains0.2588Inherited
Integrin beta tail domain0.2588Inherited
Complement control module/SCR domain0.3509Inherited
Interleukin 17F, IL-17F0.3626Inherited
FHA domain0.5226Inherited
EGF-type module0.7446Inherited
G proteins0.9762Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Immunoglobulin0.0000001379Direct
DEATH domain0.0000009442Direct
SH2 domain0.000007737Direct
Toll/Interleukin receptor TIR domain0.00004041Direct
Caspase-like0.0000413Direct
p53-like transcription factors0.0001958Direct
Inhibitor of apoptosis (IAP) repeat0.002124Inherited
SH3-domain0.002436Inherited
TNF receptor-like0.007615Inherited
Integrin alpha N-terminal domain0.008584Inherited
TNF-like0.008739Inherited
PH domain-like0.01033Inherited
Integrin domains0.01731Inherited
Family A G protein-coupled receptor-like0.01831Inherited
Bcl-2 inhibitors of programmed cell death0.02402Inherited
DBL homology domain (DH-domain)0.03027Inherited
C-type lectin-like0.037Inherited
Cysteine-rich domain0.04697Inherited
MHC antigen-recognition domain0.05325Inherited
4-helical cytokines0.06812Inherited
A DNA-binding domain in eukaryotic transcription factors0.07732Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1036Inherited
SMAD/FHA domain0.1203Inherited
Interleukin 8-like chemokines0.1397Inherited
vWA-like0.1534Inherited
E set domains0.1537Inherited
WWE domain0.1603Inherited
PLC-like phosphodiesterases0.1674Inherited
Transducin (alpha subunit), insertion domain0.2184Inherited
Integrin beta tail domain0.2408Inherited
RNI-like0.2857Inherited
Complement control module/SCR domain0.3212Inherited
Flavoproteins0.3424Inherited
L30e-like0.5158Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5411Inherited
EGF/Laminin0.6453Inherited
L domain-like0.8319Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0004372Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0004917Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0004917Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.002124Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.003211Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.005613Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.007447Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.008869Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.008869Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.008869Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0115Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02212Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.02276Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02332Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.02402Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03898Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.03898Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.04199Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.05024Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.06307Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.06307Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.06307Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.06307Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.101Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1144Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1325Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2408Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2408Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.37Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.002124Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.005613Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.005926Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.008869Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.02276Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02584Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.101Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.101Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1144Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2408Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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