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Mammalian Phenotype (MP): abnormal blood vessel morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   cardiovascular system phenotype [MP:0005385] <2>(67|85) (77|57|35)
+ 1:   abnormal cardiovascular system morphology [MP:0002127] <7>(48|65) (53|44|33)
0:   abnormal blood vessel morphology [MP:0001614] <29>(31|38) (36|27|24)
- 1:   abnormal vein morphology [MP:0002725] <17>(2|2) (2|4|2)
- 1:   abnormal artery morphology [MP:0002191] <10>(17|20) (19|16|17)
- 1:   abnormal vascular development [MP:0000259] <9>(13|24) (18|13|5)
- 1:   abnormal kidney blood vessel morphology [MP:0000530] <7>(5|5) (5|0|0)
- 1:   abnormal capillary morphology [MP:0003658] <6>(5|5) (5|0|0)
- 1:   abnormal vascular smooth muscle morphology [MP:0005592] <6>(0|0) (1|1|0)
- 1:   abnormal blood vessel endothelium morphology [MP:0009489] <4>(0|1) (0|0|0)
- 1:   abnormal retinal vasculature morphology [MP:0002792] <4>(4|3) (4|3|1)
- 1:   arteriovenous malformation [MP:0006093] <4>(0|0) (0|1|1)
- 1:   vasculature congestion [MP:0000255] <4>(4|5) (4|0|1)
- 1:   abnormal intersomitic vessel morphology [MP:0012253] <3>(1|0) (2|0|0)
- 1:   abnormal liver vasculature morphology [MP:0009820] <3>(4|4) (4|0|0)
- 1:   abnormal lung vasculature morphology [MP:0004007] <3>(4|4) (4|0|0)
- 1:   vascular stenosis [MP:0005412] <3>(0|0) (0|0|1)
- 1:   abnormal choroid vasculature morphology [MP:0006237] <2>(3|2) (3|2|1)
- 1:   abnormal placenta vasculature [MP:0003231] <2>(1|2) (1|0|0)
- 1:   abnormal blood vessel elastic tissue morphology [MP:0006083] <1>(0|2) (0|3|2)
- 1:   abnormal conjunctival vasculature morphology [MP:0006192] <1>(0|0) (0|0|0)
- 1:   abnormal cranial blood vasculature morphology [MP:0014012] <1>(0|0) (0|0|0)
- 1:   dilated vasculature [MP:0004938] <1>(0|1) (0|0|0)
- 1:   abnormal pericyte morphology [MP:0003719](0|0) (0|0|0)
- 1:   abnormal perivascular macrophage morphology [MP:0008242](0|0) (0|0|0)
- 1:   abnormal stria vascularis vasculature morphology [MP:0004368](0|0) (0|0|0)
- 1:   abnormal urinary bladder blood vessel morphology [MP:0011773](0|0) (0|0|0)
- 1:   atretic vasculature [MP:0000265](0|0) (0|0|0)
- 1:   hemangioma [MP:0014086](0|0) (0|0|0)
- 1:   perivascular fibrosis [MP:0011749](4|4) (4|0|0)
- 1:   vascular diverticulum [MP:0013869](0|0) (0|0|0)
- 1:   vasculature degeneration [MP:0012562](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
EGF/Laminin0.0000146Direct
Calcium-dependent phosphotriesterase0.0001678Direct
Integrin beta tail domain0.000756Direct
Notch domain0.0008755Direct
FnI-like domain0.005379Inherited
YWTD domain0.0107Inherited
Cytokine0.01573Inherited
Integrin domains0.02221Inherited
Growth factor receptor domain0.02947Inherited
p53-like transcription factors0.03407Inherited
Tetraspanin0.05046Inherited
PYP-like sensor domain (PAS domain)0.06155Inherited
PGBD-like0.08535Inherited
Hemopexin-like domain0.1172Inherited
Metalloproteases ("zincins"), catalytic domain0.1707Inherited
Homeodomain-like0.1889Inherited
TB module/8-cys domain0.2189Inherited
Nuclear receptor ligand-binding domain0.2361Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2926Inherited
Interleukin 8-like chemokines0.2954Inherited
Kringle-like0.2954Inherited
Flavoproteins0.2976Inherited
Riboflavin synthase domain-like0.3449Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3449Inherited
Frizzled cysteine-rich domain0.3619Inherited
E set domains0.3676Inherited
Snake toxin-like0.3686Inherited
SH3-domain0.4816Inherited
Trypsin-like serine proteases0.7562Inherited
Protein kinase-like (PK-like)0.9538Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Interleukin-1 (IL-1)0Direct
Integrin beta EGF-like domains0.000114Direct
Pointed domain0.0005412Direct
Integrin beta tail domain0.0005412Direct
Notch domain0.0006104Direct
EGF-type module0.001066Inherited
Erythroid transcription factor GATA-10.001528Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.001804Inherited
YWTD domain0.008838Inherited
ets domain0.01378Inherited
Integrin domains0.01783Inherited
Forkhead DNA-binding domain0.01886Inherited
Transforming growth factor (TGF)-beta0.04725Inherited
MMP N-terminal domain0.07178Inherited
Fibroblast growth factors (FGF)0.07178Inherited
Matrix metalloproteases, catalytic domain0.07178Inherited
Linker histone H1/H50.07842Inherited
Hemopexin-like domain0.1009Inherited
DBL homology domain (DH-domain)0.1218Inherited
Homeodomain0.1253Inherited
TB module/8-cys domain0.1953Inherited
ZZ domain0.1953Inherited
Nuclear receptor ligand-binding domain0.2262Inherited
Nuclear receptor0.2262Inherited
Fibronectin type III0.2282Inherited
Cytochrome p450 reductase N-terminal domain-like0.2715Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.2715Inherited
NADPH-cytochrome p450 reductase-like0.2715Inherited
Interleukin 8-like chemokines0.2874Inherited
Growth factor receptor domain0.3106Inherited
Kringle modules0.3222Inherited
Frizzled cysteine-rich domain0.343Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.4106Inherited
Eukaryotic proteases0.4183Inherited
SH3-domain0.5234Inherited
LIM domain0.8368Inherited
Protein kinases, catalytic subunit0.8915Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
EGF/Laminin0.000006487Direct
Calcium-dependent phosphotriesterase0.00008416Direct
Integrin beta tail domain0.0004063Direct
Notch domain0.0004738Direct
FnI-like domain0.003231Inherited
YWTD domain0.006714Inherited
Cytokine0.01013Inherited
Integrin domains0.0147Inherited
Growth factor receptor domain0.02002Inherited
p53-like transcription factors0.02338Inherited
Tetraspanin0.03565Inherited
PYP-like sensor domain (PAS domain)0.04444Inherited
PGBD-like0.06338Inherited
4-helical cytokines0.07127Inherited
Hemopexin-like domain0.09024Inherited
DBL homology domain (DH-domain)0.09636Inherited
Metalloproteases ("zincins"), catalytic domain0.1367Inherited
Homeodomain-like0.1532Inherited
Fibronectin type III0.1668Inherited
TB module/8-cys domain0.1807Inherited
Nuclear receptor ligand-binding domain0.1968Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2498Inherited
Kringle-like0.2524Inherited
Interleukin 8-like chemokines0.2524Inherited
Flavoproteins0.2544Inherited
Riboflavin synthase domain-like0.2995Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2995Inherited
Frizzled cysteine-rich domain0.3162Inherited
E set domains0.3217Inherited
Snake toxin-like0.3228Inherited
Ankyrin repeat0.4274Inherited
SH3-domain0.4339Inherited
Trypsin-like serine proteases0.7182Inherited
PH domain-like0.8454Inherited
Protein kinase-like (PK-like)0.9328Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000000639Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00000118Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.000002153Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0002654Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0004063Direct
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.0004063Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0004063Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.001156Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.001888Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.001888Inherited
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.002577Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.002577Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0047Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.0047Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.005207Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.01013Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.02137Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.055Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.06338Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.07711Inherited
    49854,49854
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0.128Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2297Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.2524Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2741Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.7511Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0000108Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00008416Direct
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.00008416Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00008611Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001403Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0004063Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0004063Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0004063Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0004738Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0004738Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0004738Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0004738Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0007164Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.001888Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.001888Inherited
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.002481Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.008207Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.01758Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1807Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2297Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2544Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6377Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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