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Mammalian Phenotype (MP): abnormal apoptosis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   cellular phenotype [MP:0005384] <6>(95|116) (103|56|31)
+ + 2:   abnormal cell physiology [MP:0005621] <24>(77|96) (84|46|25)
+ 1:   abnormal cell death [MP:0000313] <5>(29|41) (33|15|5)
0:   abnormal apoptosis [MP:0001648] <30>(27|38) (30|13|5)
- 1:   increased apoptosis [MP:0006042] <34>(16|23) (18|7|3)
- 1:   decreased apoptosis [MP:0006043] <18>(3|5) (5|3|1)
- 1:   abnormal T cell apoptosis [MP:0006412] <4>(2|3) (2|1|0)
- 1:   abnormal embryonic tissue cell apoptosis [MP:0013503] <4>(0|1) (0|0|0)
- 1:   abnormal B cell apoptosis [MP:0008781] <3>(2|3) (2|1|1)
- 1:   abnormal glial cell apoptosis [MP:0010170] <3>(0|0) (0|0|0)
- 1:   abnormal pancreatic islet cell apoptosis [MP:0009488] <3>(0|0) (0|0|0)
- 1:   abnormal anoikis [MP:0011809] <2>(0|0) (0|0|0)
- 1:   abnormal cardiomyocyte apoptosis [MP:0003221] <2>(0|1) (1|0|0)
- 1:   abnormal chondrocyte apoptosis [MP:0014102] <2>(0|0) (0|0|0)
- 1:   abnormal fetal cardiomyocyte apoptosis [MP:0011391] <2>(0|0) (0|0|0)
- 1:   abnormal fibroblast apoptosis [MP:0013500] <2>(1|1) (1|0|0)
- 1:   abnormal keratinocyte apoptosis [MP:0001224] <2>(0|0) (0|0|0)
- 1:   abnormal kidney apoptosis [MP:0011367] <2>(4|4) (4|0|0)
- 1:   abnormal macrophage apoptosis [MP:0011073] <2>(2|1) (2|1|0)
- 1:   abnormal neuron apoptosis [MP:0003202] <2>(2|4) (3|1|0)
- 1:   abnormal skeletal muscle cell apoptosis [MP:0020239] <2>(0|0) (0|0|0)
- 1:   abnormal splenocyte apoptosis [MP:0009340] <2>(0|0) (0|0|0)
- 1:   abnormal vascular endothelial cell apoptosis [MP:0020320] <2>(0|0) (0|0|0)
- 1:   abnormal vascular regression [MP:0000364] <2>(1|1) (1|1|0)
- 1:   abnormal dendritic cell apoptosis [MP:0013259] <1>(0|0) (0|0|0)
- 1:   abnormal enterocyte apoptosis [MP:0008884] <1>(1|1) (1|0|0)
- 1:   abnormal interdigital cell death [MP:0009874] <1>(1|1) (1|0|0)
- 1:   abnormal lens epithelium apoptosis [MP:0008793] <1>(0|0) (0|0|0)
- 1:   abnormal lens fiber apoptosis [MP:0008795] <1>(0|0) (0|0|0)
- 1:   abnormal male germ cell apoptosis [MP:0008280] <1>(1|2) (1|0|0)
- 1:   abnormal ovary apoptosis [MP:0013506] <1>(0|0) (0|0|0)
- 1:   abnormal epidermal stem cell apoptosis [MP:0011007](0|0) (0|0|0)
- 1:   abnormal primordial germ cell apoptosis [MP:0011610](0|0) (0|0|0)
- 1:   abnormal retinal apoptosis [MP:0006072](1|2) (2|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SRF-like0Direct
p53 tetramerization domain0Direct
Tubby C-terminal domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
The spindle assembly checkpoint protein mad20Direct
p53-like transcription factors0.00000004729Direct
Caspase-like0.0000003826Direct
Bcl-2 inhibitors of programmed cell death0.000791Direct
STAT0.001107Inherited
Transcription factor STAT-4 N-domain0.001107Inherited
Ran binding protein zinc finger-like0.002022Inherited
Cullin repeat-like0.004432Inherited
Flavoproteins0.01032Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01782Inherited
Riboflavin synthase domain-like0.01782Inherited
Nucleic acid-binding proteins0.1187Inherited
Cystine-knot cytokines0.1433Inherited
Arginase/deacetylase0.2103Inherited
SH2 domain0.4319Inherited
PYP-like sensor domain (PAS domain)0.5902Inherited
Leucine zipper domain0.6318Inherited
Inhibitor of apoptosis (IAP) repeat0.6324Inherited
Rhodanese/Cell cycle control phosphatase0.6324Inherited
Cyclin-like0.6774Inherited
DEATH domain0.6873Inherited
BRCT domain0.8057Inherited
Fibronectin type III0.9981Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Inhibitor of apoptosis (IAP) repeat0Direct
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cullin repeat0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
The spindle assembly checkpoint protein mad20Direct
p53 DNA-binding domain-like0Direct
U-box0Direct
SRF-like0Direct
p53 tetramerization domain0Direct
Transcriptional factor tubby, C-terminal domain0Direct
Caspase catalytic domain0.0000000285Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000000175Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.000004793Direct
Extracellular domain of cell surface receptors0.0001335Direct
Bcl-2 inhibitors of programmed cell death0.0005515Direct
STAT DNA-binding domain0.0007626Direct
STAT0.0007626Direct
Transcription factor STAT-4 N-domain0.0007626Direct
NADPH-cytochrome p450 reductase-like0.0008208Direct
SCF ubiquitin ligase complex WHB domain0.0008208Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0008208Direct
Ran binding protein zinc finger-like0.001534Inherited
Single strand DNA-binding domain, SSB0.00777Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.01229Inherited
ets domain0.05239Inherited
Histone deacetylase, HDAC0.1233Inherited
Transforming growth factor (TGF)-beta0.1914Inherited
SH2 domain0.4158Inherited
HLH, helix-loop-helix DNA-binding domain0.4605Inherited
I set domains0.5499Inherited
Tudor domain0.5655Inherited
Leucine zipper domain0.6152Inherited
Cell cycle control phosphatase, catalytic domain0.6541Inherited
WW domain0.6541Inherited
Toll/Interleukin receptor TIR domain0.7031Inherited
Caspase recruitment domain, CARD0.7609Inherited
Fibronectin type III0.9988Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Tubby C-terminal domain-like0Direct
SRF-like0Direct
The spindle assembly checkpoint protein mad20Direct
p53-like transcription factors0.00000001825Direct
Caspase-like0.0000001538Direct
Bcl-2 inhibitors of programmed cell death0.0004262Direct
STAT0.0006077Direct
Transcription factor STAT-4 N-domain0.0006077Direct
Ran binding protein zinc finger-like0.00115Inherited
Cullin repeat-like0.002625Inherited
Flavoproteins0.006459Inherited
Riboflavin synthase domain-like0.0116Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0116Inherited
Nucleic acid-binding proteins0.09151Inherited
Cystine-knot cytokines0.1128Inherited
Arginase/deacetylase0.1727Inherited
SH2 domain0.3848Inherited
HLH, helix-loop-helix DNA-binding domain0.4298Inherited
PYP-like sensor domain (PAS domain)0.5441Inherited
Leucine zipper domain0.5873Inherited
Inhibitor of apoptosis (IAP) repeat0.5881Inherited
Rhodanese/Cell cycle control phosphatase0.5881Inherited
WW domain0.6354Inherited
Cyclin-like0.6354Inherited
DEATH domain0.6457Inherited
BRCT domain0.7713Inherited
Immunoglobulin0.9762Inherited
Fibronectin type III0.9847Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000001035Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0001305Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0006077Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0006077Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0006077Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0006686Direct
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02769Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.6354Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.686Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7841Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0006077Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0006077Direct
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05911Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.686Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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