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Mammalian Phenotype (MP): abnormal homeostasis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
0:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
- 1:   abnormal urine homeostasis [MP:0009643] <38>(9|7) (13|3|0)
- 1:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
- 1:   abnormal enzyme/coenzyme level [MP:0005319] <22>(7|9) (10|3|0)
- 1:   abnormal hormone level [MP:0003953] <15>(27|29) (30|17|8)
- 1:   abnormal ion homeostasis [MP:0001765] <15>(9|12) (11|4|0)
- 1:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
- 1:   abnormal glucose homeostasis [MP:0002078] <14>(15|22) (17|17|8)
- 1:   abnormal fluid regulation [MP:0001784] <13>(9|17) (10|9|4)
- 1:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
- 1:   abnormal gas homeostasis [MP:0003948] <7>(10|9) (11|2|2)
- 1:   abnormal amino acid level [MP:0005332] <5>(8|9) (9|2|0)
- 1:   abnormal catecholamine level [MP:0011479] <4>(4|3) (4|2|0)
- 1:   abnormal mineral homeostasis [MP:0005636] <4>(5|6) (5|1|0)
- 1:   abnormal adaptive thermogenesis [MP:0011019] <3>(6|6) (6|4|2)
- 1:   abnormal pH regulation [MP:0004043] <3>(2|2) (2|0|0)
- 1:   abnormal susceptibility to non-insulin-dependent diabetes [MP:0020086] <3>(0|0) (0|0|0)
- 1:   abnormal vitamin homeostasis [MP:0004019] <3>(3|3) (3|0|0)
- 1:   abnormal body temperature [MP:0005535] <2>(1|0) (1|0|0)
- 1:   abnormal body temperature homeostasis [MP:0001777] <2>(3|3) (3|0|0)
- 1:   abnormal glycosaminoglycan level [MP:0011475] <2>(2|1) (2|0|0)
- 1:   abnormal porphyrin level [MP:0011989] <2>(0|0) (0|0|0)
- 1:   abnormal energy homeostasis [MP:0005448] <1>(4|5) (6|4|1)
- 1:   abnormal lipoprotein level [MP:0010329] <1>(7|8) (8|4|4)
- 1:   photosensitivity [MP:0001999] <1>(0|0) (0|0|0)
- 1:   abnormal galactose homeostasis [MP:0004018](0|0) (0|0|0)
- 1:   abnormal histamine physiology [MP:0002503](0|0) (0|0|0)
- 1:   phototoxicity [MP:0005653](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Metallothionein0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Notch domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
HMA, heavy metal-associated domain0Direct
GLA-domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Lipoxigenase0Direct
Radical SAM enzymes0Direct
p53 tetramerization domain0Direct
Ammonium transporter0Direct
FAS1 domain0Direct
Lamin A/C globular tail domain0Direct
Hormone receptor domain0.0004019Direct
PLP-dependent transferases0.00607Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.006371Inherited
Acyl-CoA dehydrogenase NM domain-like0.006371Inherited
MFS general substrate transporter0.007838Inherited
Aquaporin-like0.008047Inherited
Glycerol-3-phosphate (1)-acyltransferase0.008047Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.01163Inherited
SMAD MH1 domain0.01189Inherited
Transcription factor STAT-4 N-domain0.02166Inherited
STAT0.02166Inherited
KA1-like0.03912Inherited
Thioesterase/thiol ester dehydrase-isomerase0.03912Inherited
Insulin-like0.04032Inherited
DHS-like NAD/FAD-binding domain0.04032Inherited
C-type lectin-like0.04442Inherited
SNF-like0.04556Inherited
Nuclear receptor ligand-binding domain0.05383Inherited
Family A G protein-coupled receptor-like0.05632Inherited
ACT-like0.06923Inherited
Serum albumin-like0.06923Inherited
FAD-binding/transporter-associated domain-like0.06923Inherited
Nuclear receptor coactivator interlocking domain0.06923Inherited
Apolipoprotein A-I0.06923Inherited
Transducin (alpha subunit), insertion domain0.0801Inherited
SH2 domain0.1049Inherited
Galactose mutarotase-like0.107Inherited
Triple coiled coil domain of C-type lectins0.1211Inherited
ClpP/crotonase0.1322Inherited
Clathrin adaptor appendage domain0.1322Inherited
Cation efflux protein transmembrane domain-like0.1686Inherited
GAT-like domain0.1686Inherited
PYP-like sensor domain (PAS domain)0.1885Inherited
(Trans)glycosidases0.1885Inherited
p53-like transcription factors0.1981Inherited
GroEL equatorial domain-like0.2594Inherited
Lipocalins0.2812Inherited
Integrin domains0.2812Inherited
Alkaline phosphatase-like0.3063Inherited
4-helical cytokines0.3091Inherited
Cystine-knot cytokines0.3292Inherited
Toll/Interleukin receptor TIR domain0.3314Inherited
E set domains0.3707Inherited
HMG-box0.3729Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3798Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.3966Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4219Inherited
Riboflavin synthase domain-like0.4219Inherited
Bet v1-like0.4219Inherited
PH domain-like0.4257Inherited
CBS-domain pair0.4583Inherited
DEATH domain0.4616Inherited
Carbonic anhydrase0.4905Inherited
Glycosyl hydrolase domain0.5382Inherited
YWTD domain0.5382Inherited
Phoshotransferase/anion transport protein0.5382Inherited
Actin-like ATPase domain0.557Inherited
Flavoproteins0.5832Inherited
Growth factor receptor domain0.6146Inherited
TNF receptor-like0.6204Inherited
Thioredoxin-like0.6211Inherited
Multidrug efflux transporter AcrB transmembrane domain0.6322Inherited
Clc chloride channel0.6322Inherited
LDL receptor-like module0.6387Inherited
Heme-dependent peroxidases0.685Inherited
HLH, helix-loop-helix DNA-binding domain0.6942Inherited
Homeodomain-like0.7351Inherited
CCCH zinc finger0.7833Inherited
CAD & PB1 domains0.7887Inherited
Cytochrome P4500.7949Inherited
FAD/NAD(P)-binding domain0.7952Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.7966Inherited
Thyroglobulin type-1 domain0.8152Inherited
EGF/Laminin0.8256Inherited
alpha/beta-Hydrolases0.8297Inherited
Kringle-like0.8456Inherited
PLC-like phosphodiesterases0.8571Inherited
Caspase-like0.8571Inherited
Cyclin-like0.8604Inherited
NAD(P)-binding Rossmann-fold domains0.8626Inherited
Intermediate filament protein, coiled coil region0.8781Inherited
Inhibitor of apoptosis (IAP) repeat0.9223Inherited
Fibronectin type III0.9234Inherited
Protein kinase-like (PK-like)0.924Inherited
Cytokine0.9623Inherited
Trypsin-like serine proteases0.9929Inherited
ENTH/VHS domain0.9938Inherited
Immunoglobulin1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Serum paraoxonase/arylesterase 1, PON10Direct
HMA, heavy metal-associated domain0Direct
gamma-adaptin C-terminal appendage domain-like0Direct
Anaphylotoxins (complement system)0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
FAS1 domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Animal lipoxigenases0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Carboxylesterase0Direct
HCDH C-domain-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Lamin A/C globular tail domain0Direct
Apolipoprotein A-I0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
p53 DNA-binding domain-like0Direct
Phenylalanine metabolism regulatory domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Notch domain0Direct
p53 tetramerization domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Ammonium transporter0Direct
GLA-domain0Direct
Metallothionein0Direct
IP3 receptor type 1 binding core, domain 20Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Cytidylyltransferase0Direct
Erythroid transcription factor GATA-10Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Neurolysin-like0Direct
Neurotrophin0Direct
Sir2 family of transcriptional regulators0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
NADPH-cytochrome p450 reductase-like0Direct
Choline/Carnitine O-acyltransferase0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Multidomain cupredoxins0Direct
Hormone receptor domain0.0003071Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0003453Direct
Short-chain cytokines0.0003453Direct
GABA-aminotransferase-like0.004881Inherited
Aquaporin-like0.006389Inherited
SMAD domain0.009229Inherited
SMAD MH1 domain0.009229Inherited
STAT0.01712Inherited
Pancreatic lipase, N-terminal domain0.01712Inherited
L domain0.01712Inherited
Transcription factor STAT-4 N-domain0.01712Inherited
STAT DNA-binding domain0.01712Inherited
Fatty acid binding protein-like0.02482Inherited
Lipoxigenase N-terminal domain0.03133Inherited
C-type lectin domain0.03257Inherited
Insulin-like0.03313Inherited
SNF-like0.03895Inherited
Nuclear receptor ligand-binding domain0.03911Inherited
Nuclear receptor0.04733Inherited
Serum albumin-like0.05726Inherited
Nuclear receptor coactivator interlocking domain0.05726Inherited
Transducin (alpha subunit), insertion domain0.07087Inherited
Rhodopsin-like0.07194Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.09252Inherited
Pyrin domain, PYD0.09252Inherited
beta-glycanases0.1034Inherited
Crotonase-like0.1034Inherited
GAT domain0.1034Inherited
Triple coiled coil domain of C-type lectins0.1034Inherited
Kinase associated domain 1, KA10.1034Inherited
Acetyl-CoA synthetase-like0.1135Inherited
SH2 domain0.1141Inherited
Interferon regulatory factor0.1171Inherited
Phosphotyrosine-binding domain (PTB)0.1202Inherited
EGF-type module0.1459Inherited
Noncollagenous (NC1) domain of collagen IV0.1491Inherited
Cation efflux protein transmembrane domain-like0.1491Inherited
E2F dimerization segment0.1491Inherited
28-residue LRR0.2223Inherited
Integrin domains0.2426Inherited
Chaperone J-domain0.2841Inherited
Toll/Interleukin receptor TIR domain0.3178Inherited
TNF receptor-like0.348Inherited
T-box0.348Inherited
Forkhead DNA-binding domain0.3753Inherited
HMG-box0.3757Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.3791Inherited
Meta-cation ATPase, catalytic domain P0.3791Inherited
Transforming growth factor (TGF)-beta0.3819Inherited
Pleckstrin-homology domain (PH domain)0.395Inherited
PLC-like (P variant)0.4012Inherited
CBS-domain pair0.4156Inherited
Growth factor receptor domain0.4469Inherited
Carbonic anhydrase0.4771Inherited
YWTD domain0.4969Inherited
Arylsulfatase0.5011Inherited
Interferons/interleukin-10 (IL-10)0.5011Inherited
VHS domain0.5139Inherited
Platelet-derived growth factor-like0.5416Inherited
Anion transport protein, cytoplasmic domain0.5416Inherited
Papain-like0.5416Inherited
Mammalian PLC0.5416Inherited
ABC transporter transmembrane region0.5455Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.5669Inherited
Cytochrome b50.5928Inherited
Clc chloride channel0.5928Inherited
LDL receptor-like module0.5978Inherited
p120GAP domain-like0.6478Inherited
Myeloperoxidase-like0.6478Inherited
Pointed domain0.6478Inherited
Interleukin-1 (IL-1)0.6478Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.6478Inherited
Homeodomain0.6734Inherited
ABC transporter ATPase domain-like0.681Inherited
CAD domain0.7076Inherited
HLH, helix-loop-helix DNA-binding domain0.725Inherited
G proteins0.7258Inherited
DEATH domain, DD0.735Inherited
Long-chain cytokines0.7562Inherited
Cytochrome P4500.7616Inherited
CCCH zinc finger0.7733Inherited
Thyroglobulin type-1 domain0.8078Inherited
Caspase recruitment domain, CARD0.8308Inherited
Caspase catalytic domain0.8308Inherited
Intermediate filament protein, coiled coil region0.8832Inherited
Inhibitor of apoptosis (IAP) repeat0.9022Inherited
Fibronectin type III0.9123Inherited
Cyclin0.9548Inherited
Kringle modules0.9565Inherited
Eukaryotic proteases0.9666Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
HMA, heavy metal-associated domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
GLA-domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Notch domain0Direct
Lipoxigenase0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Metallothionein0Direct
Radical SAM enzymes0Direct
FAS1 domain0Direct
Anaphylotoxins (complement system)0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Ammonium transporter0Direct
Lamin A/C globular tail domain0Direct
Hormone receptor domain0.0002098Direct
PLP-dependent transferases0.003675Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.00388Inherited
Acyl-CoA dehydrogenase NM domain-like0.00388Inherited
MFS general substrate transporter0.00482Inherited
Glycerol-3-phosphate (1)-acyltransferase0.00496Inherited
Aquaporin-like0.00496Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.007362Inherited
SMAD MH1 domain0.007531Inherited
Transcription factor STAT-4 N-domain0.01431Inherited
STAT0.01431Inherited
KA1-like0.02708Inherited
Thioesterase/thiol ester dehydrase-isomerase0.02708Inherited
Insulin-like0.02803Inherited
DHS-like NAD/FAD-binding domain0.02803Inherited
C-type lectin-like0.03109Inherited
SNF-like0.03199Inherited
Nuclear receptor ligand-binding domain0.03826Inherited
Family A G protein-coupled receptor-like0.04026Inherited
Apolipoprotein A-I0.05063Inherited
Nuclear receptor coactivator interlocking domain0.05063Inherited
Serum albumin-like0.05063Inherited
FAD-binding/transporter-associated domain-like0.05063Inherited
ACT-like0.05063Inherited
Transducin (alpha subunit), insertion domain0.05915Inherited
SH2 domain0.07963Inherited
Galactose mutarotase-like0.08144Inherited
Triple coiled coil domain of C-type lectins0.09349Inherited
Acetyl-CoA synthetase-like0.09665Inherited
ClpP/crotonase0.1031Inherited
Clathrin adaptor appendage domain0.1031Inherited
GAT-like domain0.1348Inherited
Cation efflux protein transmembrane domain-like0.1348Inherited
(Trans)glycosidases0.1529Inherited
PYP-like sensor domain (PAS domain)0.1529Inherited
p53-like transcription factors0.1615Inherited
t-snare proteins0.1749Inherited
GroEL equatorial domain-like0.2184Inherited
Integrin domains0.2392Inherited
Lipocalins0.2392Inherited
E2F-DP heterodimerization region0.2406Inherited
Chaperone J-domain0.2447Inherited
Alkaline phosphatase-like0.2627Inherited
4-helical cytokines0.2654Inherited
Cystine-knot cytokines0.2847Inherited
Toll/Interleukin receptor TIR domain0.2868Inherited
E set domains0.3248Inherited
HMG-box0.327Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3337Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.3501Inherited
Bet v1-like0.3751Inherited
Riboflavin synthase domain-like0.3751Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3751Inherited
PH domain-like0.379Inherited
CBS-domain pair0.4105Inherited
DEATH domain0.4139Inherited
Carbonic anhydrase0.4428Inherited
ABC transporter transmembrane region0.4801Inherited
Phoshotransferase/anion transport protein0.4912Inherited
YWTD domain0.4912Inherited
Glycosyl hydrolase domain0.4912Inherited
Actin-like ATPase domain0.5102Inherited
Flavoproteins0.5369Inherited
Growth factor receptor domain0.5694Inherited
TNF receptor-like0.5753Inherited
Thioredoxin-like0.5762Inherited
Clc chloride channel0.5878Inherited
Multidrug efflux transporter AcrB transmembrane domain0.5878Inherited
Phospholipase A2, PLA20.5878Inherited
LDL receptor-like module0.5945Inherited
Heme-dependent peroxidases0.6433Inherited
HLH, helix-loop-helix DNA-binding domain0.653Inherited
Homeodomain-like0.6964Inherited
TNF-like0.7404Inherited
CCCH zinc finger0.7474Inherited
CAD & PB1 domains0.7531Inherited
Cytochrome P4500.7598Inherited
FAD/NAD(P)-binding domain0.7601Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.7616Inherited
Thyroglobulin type-1 domain0.7813Inherited
EGF/Laminin0.7925Inherited
alpha/beta-Hydrolases0.797Inherited
Kringle-like0.814Inherited
Caspase-like0.8265Inherited
PLC-like phosphodiesterases0.8265Inherited
Cyclin-like0.8301Inherited
NAD(P)-binding Rossmann-fold domains0.8326Inherited
Intermediate filament protein, coiled coil region0.8494Inherited
Inhibitor of apoptosis (IAP) repeat0.8975Inherited
Fibronectin type III0.8987Inherited
Protein kinase-like (PK-like)0.8994Inherited
FnI-like domain0.912Inherited
Cytokine0.9423Inherited
P-loop containing nucleoside triphosphate hydrolases0.9632Inherited
Trypsin-like serine proteases0.9783Inherited
ENTH/VHS domain0.9794Inherited
SMAD/FHA domain0.9988Inherited
Immunoglobulin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46565,57938
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    48452,57850
  • 48452 - TPR-like
  • 57850 - RING/U-box
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    48403,50044
  • 48403 - Ankyrin repeat
  • 50044 - SH3-domain
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.00388Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00388Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.007362Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.01431Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01431Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01431Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01431Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01431Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01431Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.02708Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.04834Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.05063Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.08142Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.08144Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08837Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.09349Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.1031Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1348Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.1348Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.1348Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1396Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.1594Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.1594Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1749Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.2406Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2868Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3174Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.3541Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3558Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.3632Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.4105Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4742Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4801Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.4912Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.514Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.5415Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.5878Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.5878Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.5878Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.6433Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.6808Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.7029Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.8169Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.8975Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.912Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.9818Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    46565,57938,49493
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01431Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01431Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01431Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01444Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.02708Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.02708Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.02708Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.04017Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.09349Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1295Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.1348Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1348Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1594Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.2184Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.2406Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.3135Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6441Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.7029Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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