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Mammalian Phenotype (MP): abnormal homeostasis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
0:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
- 1:   abnormal urine homeostasis [MP:0009643] <38>(9|7) (13|3|0)
- 1:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
- 1:   abnormal enzyme/coenzyme level [MP:0005319] <22>(7|9) (10|3|0)
- 1:   abnormal hormone level [MP:0003953] <15>(27|29) (30|17|8)
- 1:   abnormal ion homeostasis [MP:0001765] <15>(9|12) (11|4|0)
- 1:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
- 1:   abnormal glucose homeostasis [MP:0002078] <14>(15|22) (17|17|8)
- 1:   abnormal fluid regulation [MP:0001784] <13>(9|17) (10|9|4)
- 1:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
- 1:   abnormal gas homeostasis [MP:0003948] <7>(10|9) (11|2|2)
- 1:   abnormal amino acid level [MP:0005332] <5>(8|9) (9|2|0)
- 1:   abnormal catecholamine level [MP:0011479] <4>(4|3) (4|2|0)
- 1:   abnormal mineral homeostasis [MP:0005636] <4>(5|6) (5|1|0)
- 1:   abnormal adaptive thermogenesis [MP:0011019] <3>(6|6) (6|4|2)
- 1:   abnormal pH regulation [MP:0004043] <3>(2|2) (2|0|0)
- 1:   abnormal susceptibility to non-insulin-dependent diabetes [MP:0020086] <3>(0|0) (0|0|0)
- 1:   abnormal vitamin homeostasis [MP:0004019] <3>(3|3) (3|0|0)
- 1:   abnormal body temperature [MP:0005535] <2>(1|0) (1|0|0)
- 1:   abnormal body temperature homeostasis [MP:0001777] <2>(3|3) (3|0|0)
- 1:   abnormal glycosaminoglycan level [MP:0011475] <2>(2|1) (2|0|0)
- 1:   abnormal porphyrin level [MP:0011989] <2>(0|0) (0|0|0)
- 1:   abnormal energy homeostasis [MP:0005448] <1>(4|5) (6|4|1)
- 1:   abnormal lipoprotein level [MP:0010329] <1>(7|8) (8|4|4)
- 1:   photosensitivity [MP:0001999] <1>(0|0) (0|0|0)
- 1:   abnormal galactose homeostasis [MP:0004018](0|0) (0|0|0)
- 1:   abnormal histamine physiology [MP:0002503](0|0) (0|0|0)
- 1:   phototoxicity [MP:0005653](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Metallothionein0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Radical SAM enzymes0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
p53 tetramerization domain0Direct
GLA-domain0Direct
FAS1 domain0Direct
Lamin A/C globular tail domain0Direct
Ammonium transporter0Direct
Lipoxigenase0Direct
HMA, heavy metal-associated domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Notch domain0Direct
Hormone receptor domain0.0004016Direct
PLP-dependent transferases0.006067Inherited
Acyl-CoA dehydrogenase NM domain-like0.006368Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.006368Inherited
MFS general substrate transporter0.007831Inherited
Aquaporin-like0.008046Inherited
Glycerol-3-phosphate (1)-acyltransferase0.008046Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.01163Inherited
SMAD MH1 domain0.01189Inherited
STAT0.02164Inherited
Transcription factor STAT-4 N-domain0.02164Inherited
Thioesterase/thiol ester dehydrase-isomerase0.0391Inherited
KA1-like0.0391Inherited
DHS-like NAD/FAD-binding domain0.04028Inherited
Insulin-like0.04028Inherited
C-type lectin-like0.04435Inherited
SNF-like0.04554Inherited
Nuclear receptor ligand-binding domain0.05388Inherited
Family A G protein-coupled receptor-like0.05643Inherited
Serum albumin-like0.06922Inherited
Nuclear receptor coactivator interlocking domain0.06922Inherited
FAD-binding/transporter-associated domain-like0.06922Inherited
Apolipoprotein A-I0.06922Inherited
ACT-like0.06922Inherited
Transducin (alpha subunit), insertion domain0.08003Inherited
Galactose mutarotase-like0.1069Inherited
SH2 domain0.1211Inherited
Triple coiled coil domain of C-type lectins0.1212Inherited
ClpP/crotonase0.1321Inherited
Clathrin adaptor appendage domain0.1321Inherited
GAT-like domain0.1685Inherited
Cation efflux protein transmembrane domain-like0.1685Inherited
(Trans)glycosidases0.1887Inherited
PYP-like sensor domain (PAS domain)0.1887Inherited
p53-like transcription factors0.1983Inherited
GroEL equatorial domain-like0.2594Inherited
Integrin domains0.2814Inherited
Lipocalins0.2814Inherited
Alkaline phosphatase-like0.3062Inherited
4-helical cytokines0.3094Inherited
Cystine-knot cytokines0.3296Inherited
Toll/Interleukin receptor TIR domain0.3316Inherited
E set domains0.3708Inherited
HMG-box0.3728Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3801Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.3965Inherited
Riboflavin synthase domain-like0.4219Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4219Inherited
Bet v1-like0.4219Inherited
PH domain-like0.4449Inherited
CBS-domain pair0.4584Inherited
DEATH domain0.4618Inherited
Carbonic anhydrase0.4904Inherited
Phoshotransferase/anion transport protein0.5382Inherited
YWTD domain0.5382Inherited
Glycosyl hydrolase domain0.5382Inherited
Actin-like ATPase domain0.5571Inherited
Flavoproteins0.5833Inherited
Growth factor receptor domain0.6148Inherited
TNF receptor-like0.6203Inherited
Thioredoxin-like0.6213Inherited
Clc chloride channel0.6323Inherited
Multidrug efflux transporter AcrB transmembrane domain0.6323Inherited
LDL receptor-like module0.6389Inherited
Heme-dependent peroxidases0.6851Inherited
HLH, helix-loop-helix DNA-binding domain0.694Inherited
Homeodomain-like0.7348Inherited
CCCH zinc finger0.783Inherited
CAD & PB1 domains0.7887Inherited
Cytochrome P4500.7948Inherited
FAD/NAD(P)-binding domain0.7952Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.7965Inherited
Thyroglobulin type-1 domain0.8152Inherited
EGF/Laminin0.8257Inherited
alpha/beta-Hydrolases0.8299Inherited
Kringle-like0.8456Inherited
Caspase-like0.8572Inherited
PLC-like phosphodiesterases0.8572Inherited
Cyclin-like0.8603Inherited
NAD(P)-binding Rossmann-fold domains0.8628Inherited
Intermediate filament protein, coiled coil region0.878Inherited
Inhibitor of apoptosis (IAP) repeat0.9224Inherited
Fibronectin type III0.9236Inherited
Protein kinase-like (PK-like)0.9243Inherited
Cytokine0.9624Inherited
Trypsin-like serine proteases0.9928Inherited
ENTH/VHS domain0.9938Inherited
Immunoglobulin1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Anaphylotoxins (complement system)0Direct
Neurolysin-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
p53 DNA-binding domain-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
Notch domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Animal lipoxigenases0Direct
Multidomain cupredoxins0Direct
NADPH-cytochrome p450 reductase-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
FAS1 domain0Direct
RUNT domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Carboxylesterase0Direct
Choline/Carnitine O-acyltransferase0Direct
HCDH C-domain-like0Direct
Sir2 family of transcriptional regulators0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Neurotrophin0Direct
GLA-domain0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Cytidylyltransferase0Direct
p53 tetramerization domain0Direct
Metallothionein0Direct
Ammonium transporter0Direct
gamma-adaptin C-terminal appendage domain-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Retinoblastoma tumor suppressor domains0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Apolipoprotein A-I0Direct
HMA, heavy metal-associated domain0Direct
Phenylalanine metabolism regulatory domain0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Erythroid transcription factor GATA-10Direct
Hormone receptor domain0.0003055Direct
Short-chain cytokines0.0003433Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0003433Direct
GABA-aminotransferase-like0.004859Inherited
Aquaporin-like0.006361Inherited
SMAD MH1 domain0.0092Inherited
SMAD domain0.0092Inherited
STAT DNA-binding domain0.01706Inherited
Transcription factor STAT-4 N-domain0.01706Inherited
L domain0.01706Inherited
STAT0.01706Inherited
Pancreatic lipase, N-terminal domain0.01706Inherited
Fatty acid binding protein-like0.02473Inherited
Lipoxigenase N-terminal domain0.03125Inherited
C-type lectin domain0.03246Inherited
Insulin-like0.03306Inherited
SNF-like0.03886Inherited
Nuclear receptor ligand-binding domain0.03909Inherited
Nuclear receptor0.04729Inherited
Nuclear receptor coactivator interlocking domain0.05714Inherited
Serum albumin-like0.05714Inherited
Transducin (alpha subunit), insertion domain0.07071Inherited
Rhodopsin-like0.07193Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.09235Inherited
Pyrin domain, PYD0.09235Inherited
Crotonase-like0.1033Inherited
GAT domain0.1033Inherited
beta-glycanases0.1033Inherited
Kinase associated domain 1, KA10.1033Inherited
Triple coiled coil domain of C-type lectins0.1033Inherited
Acetyl-CoA synthetase-like0.1132Inherited
Interferon regulatory factor0.117Inherited
SH2 domain0.1313Inherited
EGF-type module0.146Inherited
Noncollagenous (NC1) domain of collagen IV0.1489Inherited
E2F dimerization segment0.1489Inherited
Cation efflux protein transmembrane domain-like0.1489Inherited
Phosphotyrosine-binding domain (PTB)0.1518Inherited
28-residue LRR0.2222Inherited
Integrin domains0.2426Inherited
Chaperone J-domain0.2838Inherited
Toll/Interleukin receptor TIR domain0.3178Inherited
TNF receptor-like0.3481Inherited
T-box0.3481Inherited
Forkhead DNA-binding domain0.3754Inherited
HMG-box0.3754Inherited
Meta-cation ATPase, catalytic domain P0.3791Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.3791Inherited
Transforming growth factor (TGF)-beta0.3815Inherited
Pleckstrin-homology domain (PH domain)0.3945Inherited
PLC-like (P variant)0.4012Inherited
CBS-domain pair0.4156Inherited
Growth factor receptor domain0.4469Inherited
Carbonic anhydrase0.4767Inherited
YWTD domain0.4968Inherited
Arylsulfatase0.5008Inherited
Interferons/interleukin-10 (IL-10)0.5008Inherited
VHS domain0.5136Inherited
Mammalian PLC0.5414Inherited
Platelet-derived growth factor-like0.5414Inherited
Papain-like0.5414Inherited
Anion transport protein, cytoplasmic domain0.5414Inherited
ABC transporter transmembrane region0.5456Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.5666Inherited
Clc chloride channel0.5927Inherited
Cytochrome b50.5927Inherited
LDL receptor-like module0.5979Inherited
Pointed domain0.6476Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.6476Inherited
Interleukin-1 (IL-1)0.6476Inherited
Myeloperoxidase-like0.6476Inherited
p120GAP domain-like0.6476Inherited
Homeodomain0.6728Inherited
ABC transporter ATPase domain-like0.6811Inherited
CAD domain0.7076Inherited
HLH, helix-loop-helix DNA-binding domain0.7246Inherited
G proteins0.7253Inherited
DEATH domain, DD0.7352Inherited
Long-chain cytokines0.7563Inherited
Cytochrome P4500.7618Inherited
CCCH zinc finger0.7731Inherited
Thyroglobulin type-1 domain0.8077Inherited
Caspase catalytic domain0.8309Inherited
Caspase recruitment domain, CARD0.8309Inherited
Intermediate filament protein, coiled coil region0.8832Inherited
Inhibitor of apoptosis (IAP) repeat0.9022Inherited
Fibronectin type III0.912Inherited
Cyclin0.9548Inherited
Kringle modules0.9565Inherited
Eukaryotic proteases0.9667Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Lipoxigenase0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Radical SAM enzymes0Direct
Metallothionein0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
HMA, heavy metal-associated domain0Direct
Notch domain0Direct
FAS1 domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
p53 tetramerization domain0Direct
GLA-domain0Direct
Lamin A/C globular tail domain0Direct
Ammonium transporter0Direct
Anaphylotoxins (complement system)0Direct
Hormone receptor domain0.0002097Direct
PLP-dependent transferases0.003669Inherited
Acyl-CoA dehydrogenase NM domain-like0.003875Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.003875Inherited
MFS general substrate transporter0.004809Inherited
Aquaporin-like0.004954Inherited
Glycerol-3-phosphate (1)-acyltransferase0.004954Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.007355Inherited
SMAD MH1 domain0.007528Inherited
STAT0.01429Inherited
Transcription factor STAT-4 N-domain0.01429Inherited
KA1-like0.02706Inherited
Thioesterase/thiol ester dehydrase-isomerase0.02706Inherited
DHS-like NAD/FAD-binding domain0.028Inherited
Insulin-like0.028Inherited
C-type lectin-like0.03103Inherited
SNF-like0.03196Inherited
Nuclear receptor ligand-binding domain0.03829Inherited
Family A G protein-coupled receptor-like0.04034Inherited
Serum albumin-like0.0506Inherited
ACT-like0.0506Inherited
Nuclear receptor coactivator interlocking domain0.0506Inherited
Apolipoprotein A-I0.0506Inherited
FAD-binding/transporter-associated domain-like0.0506Inherited
Transducin (alpha subunit), insertion domain0.05909Inherited
Galactose mutarotase-like0.08138Inherited
SH2 domain0.09343Inherited
Triple coiled coil domain of C-type lectins0.09346Inherited
Acetyl-CoA synthetase-like0.09657Inherited
Clathrin adaptor appendage domain0.103Inherited
ClpP/crotonase0.103Inherited
Cation efflux protein transmembrane domain-like0.1348Inherited
GAT-like domain0.1348Inherited
(Trans)glycosidases0.153Inherited
PYP-like sensor domain (PAS domain)0.153Inherited
p53-like transcription factors0.1616Inherited
t-snare proteins0.1749Inherited
GroEL equatorial domain-like0.2184Inherited
Lipocalins0.2393Inherited
Integrin domains0.2393Inherited
E2F-DP heterodimerization region0.2405Inherited
Chaperone J-domain0.2446Inherited
Alkaline phosphatase-like0.2627Inherited
4-helical cytokines0.2656Inherited
Cystine-knot cytokines0.285Inherited
Toll/Interleukin receptor TIR domain0.287Inherited
E set domains0.3249Inherited
HMG-box0.3269Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3339Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.35Inherited
Bet v1-like0.3751Inherited
Riboflavin synthase domain-like0.3751Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3751Inherited
PH domain-like0.3973Inherited
CBS-domain pair0.4106Inherited
DEATH domain0.4141Inherited
Carbonic anhydrase0.4427Inherited
ABC transporter transmembrane region0.4802Inherited
YWTD domain0.4912Inherited
Phoshotransferase/anion transport protein0.4912Inherited
Glycosyl hydrolase domain0.4912Inherited
Actin-like ATPase domain0.5104Inherited
Flavoproteins0.537Inherited
Growth factor receptor domain0.5696Inherited
TNF receptor-like0.5753Inherited
Thioredoxin-like0.5764Inherited
Multidrug efflux transporter AcrB transmembrane domain0.588Inherited
Clc chloride channel0.588Inherited
Phospholipase A2, PLA20.588Inherited
LDL receptor-like module0.5947Inherited
Heme-dependent peroxidases0.6434Inherited
HLH, helix-loop-helix DNA-binding domain0.6528Inherited
Homeodomain-like0.696Inherited
TNF-like0.7402Inherited
CCCH zinc finger0.7472Inherited
CAD & PB1 domains0.7532Inherited
Cytochrome P4500.7598Inherited
FAD/NAD(P)-binding domain0.7602Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.7615Inherited
Thyroglobulin type-1 domain0.7813Inherited
EGF/Laminin0.7928Inherited
alpha/beta-Hydrolases0.7973Inherited
Kringle-like0.8141Inherited
Caspase-like0.8266Inherited
PLC-like phosphodiesterases0.8266Inherited
Cyclin-like0.8301Inherited
NAD(P)-binding Rossmann-fold domains0.8328Inherited
Intermediate filament protein, coiled coil region0.8492Inherited
Inhibitor of apoptosis (IAP) repeat0.8976Inherited
Fibronectin type III0.8989Inherited
Protein kinase-like (PK-like)0.8997Inherited
FnI-like domain0.9121Inherited
Cytokine0.9424Inherited
P-loop containing nucleoside triphosphate hydrolases0.9664Inherited
Trypsin-like serine proteases0.9783Inherited
ENTH/VHS domain0.9794Inherited
SMAD/FHA domain0.9988Inherited
Immunoglobulin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    48403,50044
  • 48403 - Ankyrin repeat
  • 50044 - SH3-domain
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    46565,57938
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    48452,57850
  • 48452 - TPR-like
  • 57850 - RING/U-box
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.003875Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.003875Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.007355Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01429Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.01429Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01429Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01429Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01429Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01429Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.02706Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.04832Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.0506Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.08134Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.08138Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08831Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.09346Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.103Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.1348Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1348Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.1348Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1396Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.1593Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.1593Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1749Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.2405Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.287Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3174Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.3541Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3557Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.363Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.4106Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4744Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4802Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.4912Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.5138Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.5416Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.588Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.588Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.588Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.6434Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.6812Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.703Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.8171Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.8976Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.9121Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.9818Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    46565,57938,49493
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01429Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01429Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01429Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01442Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.02706Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.02706Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.02706Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.04014Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.09346Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1294Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.1348Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1348Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1593Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.2184Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.2405Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.3137Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6441Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.703Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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