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Mammalian Phenotype (MP): abnormal humoral immune response

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal humoral immune response [MP:0001800] <4>(10|14) (12|10|8)
- 1:   abnormal immunoglobulin level [MP:0002490] <7>(8|12) (9|9|7)
- 1:   abnormal complement pathway [MP:0002471] <6>(2|2) (2|1|1)
- 1:   enhanced humoral immune response [MP:0020155](0|0) (0|0|0)
- 1:   impaired humoral immune response [MP:0020154](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TNF receptor-like0.0004017Direct
p53-like transcription factors0.003854Inherited
Complement control module/SCR domain0.005201Inherited
L30e-like0.01085Inherited
TNF-like0.01711Inherited
Toll/Interleukin receptor TIR domain0.02491Inherited
4-helical cytokines0.03813Inherited
Bcl-2 inhibitors of programmed cell death0.06579Inherited
Family A G protein-coupled receptor-like0.497Inherited
Trypsin-like serine proteases0.9443Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00002576Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00008433Direct
TNF receptor-like0.001517Inherited
Complement control module/SCR domain0.003567Inherited
Short-chain cytokines0.003905Inherited
TNF-like0.01262Inherited
Toll/Interleukin receptor TIR domain0.03337Inherited
Bcl-2 inhibitors of programmed cell death0.05122Inherited
DEATH domain, DD0.05268Inherited
Interleukin 17F, IL-17F0.05785Inherited
V set domains (antibody variable domain-like)0.06672Inherited
I set domains0.1569Inherited
C1 set domains (antibody constant domain-like)0.1903Inherited
Eukaryotic proteases0.9168Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TNF receptor-like0.0002098Direct
SH2 domain0.0008532Direct
p53-like transcription factors0.002265Inherited
Complement control module/SCR domain0.003122Inherited
L30e-like0.006818Inherited
TNF-like0.01112Inherited
Toll/Interleukin receptor TIR domain0.01664Inherited
DEATH domain0.02063Inherited
4-helical cytokines0.02636Inherited
Bcl-2 inhibitors of programmed cell death0.04784Inherited
Family A G protein-coupled receptor-like0.4493Inherited
Trypsin-like serine proteases0.9221Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00007098Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.000415Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.002164Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.003434Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.006679Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.008934Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01731Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.02221Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.04784Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.0002495Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0002495Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0009513Direct
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02221Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.05251Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.05428Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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