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Mammalian Phenotype (MP): abnormal immune cell physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
- 1:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
- 1:   abnormal professional antigen presenting cell physiology [MP:0002452] <3>(25|32) (26|19|12)
- 1:   abnormal follicular dendritic cell physiology [MP:0008197] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
SH2 domain0.0000446Direct
Immunoglobulin0.00006299Direct
DEATH domain0.0001576Direct
SH3-domain0.0001584Direct
p53-like transcription factors0.003052Inherited
DBL homology domain (DH-domain)0.01823Inherited
Toll/Interleukin receptor TIR domain0.03012Inherited
TNF receptor-like0.03302Inherited
Caspase-like0.05644Inherited
MHC antigen-recognition domain0.05686Inherited
Flavoproteins0.07604Inherited
Interleukin 8-like chemokines0.1007Inherited
L30e-like0.11Inherited
Bcl-2 inhibitors of programmed cell death0.138Inherited
Cysteine-rich domain0.1402Inherited
Inhibitor of apoptosis (IAP) repeat0.1844Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2451Inherited
4-helical cytokines0.2621Inherited
E set domains0.2713Inherited
Integrin domains0.3074Inherited
WWE domain0.3267Inherited
TNF-like0.3356Inherited
Integrin beta tail domain0.4751Inherited
Integrin alpha N-terminal domain0.494Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5648Inherited
C-type lectin-like0.5745Inherited
SMAD/FHA domain0.6204Inherited
Family A G protein-coupled receptor-like0.6292Inherited
vWA-like0.7931Inherited
Complement control module/SCR domain0.8829Inherited
L domain-like0.9959Inherited
EGF/Laminin1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
STAT DNA-binding domain0Direct
Proteasome subunits0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cysteine rich domain0Direct
Transcription factor STAT-4 N-domain0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000006196Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00001724Direct
SH2 domain0.0000214Direct
Pyrin domain, PYD0.00007397Direct
SH3-domain0.00007996Direct
Inhibitor of apoptosis (IAP) repeat0.0003331Direct
28-residue LRR0.000726Direct
Pleckstrin-homology domain (PH domain)0.002476Inherited
C1 set domains (antibody constant domain-like)0.005262Inherited
Cytochrome p450 reductase N-terminal domain-like0.005907Inherited
V set domains (antibody variable domain-like)0.006653Inherited
DBL homology domain (DH-domain)0.01585Inherited
NADPH-cytochrome p450 reductase-like0.01827Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01827Inherited
Caspase recruitment domain, CARD0.02108Inherited
Toll/Interleukin receptor TIR domain0.02726Inherited
MHC antigen-recognition domain0.04144Inherited
TNF receptor-like0.04144Inherited
Caspase catalytic domain0.05742Inherited
DEATH domain, DD0.07711Inherited
Interleukin 8-like chemokines0.07711Inherited
I set domains0.07916Inherited
ets domain0.09073Inherited
Short-chain cytokines0.09639Inherited
Bcl-2 inhibitors of programmed cell death0.1104Inherited
PLC-like (P variant)0.1192Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2106Inherited
C-type lectin domain0.2556Inherited
Integrin domains0.2661Inherited
Interferon regulatory factor0.2693Inherited
WWE domain0.2856Inherited
TNF-like0.2923Inherited
Integrin alpha N-terminal domain0.3676Inherited
Rhodopsin-like0.391Inherited
FHA domain0.4224Inherited
Integrin beta tail domain0.4314Inherited
Integrin beta EGF-like domains0.4314Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.4314Inherited
Interleukin 17F, IL-17F0.5365Inherited
Integrin A (or I) domain0.644Inherited
Complement control module/SCR domain0.8589Inherited
EGF-type module0.983Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
SH2 domain0.00002084Direct
Immunoglobulin0.00002977Direct
DEATH domain0.00007874Direct
SH3-domain0.00007918Direct
p53-like transcription factors0.001771Inherited
DBL homology domain (DH-domain)0.01189Inherited
Toll/Interleukin receptor TIR domain0.02048Inherited
TNF receptor-like0.0226Inherited
Caspase-like0.04034Inherited
MHC antigen-recognition domain0.04069Inherited
Flavoproteins0.05598Inherited
Interleukin 8-like chemokines0.07604Inherited
L30e-like0.08408Inherited
Bcl-2 inhibitors of programmed cell death0.1082Inherited
Cysteine-rich domain0.11Inherited
RNI-like0.1175Inherited
Inhibitor of apoptosis (IAP) repeat0.1493Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2053Inherited
4-helical cytokines0.2209Inherited
E set domains0.2297Inherited
Integrin domains0.2637Inherited
WWE domain0.2823Inherited
TNF-like0.2906Inherited
Integrin beta tail domain0.4274Inherited
Integrin alpha N-terminal domain0.4463Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5182Inherited
C-type lectin-like0.528Inherited
SMAD/FHA domain0.5754Inherited
Family A G protein-coupled receptor-like0.5847Inherited
vWA-like0.7578Inherited
Transducin (alpha subunit), insertion domain0.7688Inherited
Complement control module/SCR domain0.8547Inherited
L domain-like0.9818Inherited
EGF/Laminin0.9951Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000003957Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.000269Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003016Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.004306Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.005072Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.01219Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.01789Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.02055Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0226Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.03311Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.09464Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1082Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1493Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.1493Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1493Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2053Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.2053Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.218Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2823Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.364Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.364Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.4274Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.4274Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.6227Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8042Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.005072Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.005072Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02055Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02699Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2053Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2053Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.2823Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2823Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.364Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.4274Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4409Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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