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Mammalian Phenotype (MP): abnormal inflammatory response

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal inflammatory response [MP:0001845] <4>(27|38) (29|18|5)
- 1:   increased inflammatory response [MP:0001846] <35>(23|35) (25|17|4)
- 1:   abnormal acute inflammation [MP:0002498] <6>(4|5) (4|2|1)
- 1:   chronic inflammation [MP:0002499] <1>(1|2) (1|0|0)
- 1:   decreased inflammatory response [MP:0001876] <1>(4|5) (4|2|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Resistin0Direct
p53 tetramerization domain0Direct
Alpha-macroglobulin receptor domain0.00004879Direct
Integrin beta tail domain0.00004879Direct
p53-like transcription factors0.001435Inherited
Terpenoid cyclases/Protein prenyltransferases0.00178Inherited
Nuclear receptor ligand-binding domain0.01001Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01749Inherited
Riboflavin synthase domain-like0.01749Inherited
PGBD-like0.04684Inherited
Hemopexin-like domain0.04684Inherited
Cystine-knot cytokines0.05054Inherited
L30e-like0.07903Inherited
4-helical cytokines0.0809Inherited
Family A G protein-coupled receptor-like0.08592Inherited
RNI-like0.107Inherited
Growth factor receptor domain0.1162Inherited
Kringle-like0.1834Inherited
TNF-like0.3722Inherited
DEATH domain0.3862Inherited
Toll/Interleukin receptor TIR domain0.4614Inherited
TNF receptor-like0.6454Inherited
Nicotinic receptor ligand binding domain-like0.7474Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7474Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Interleukin-1 (IL-1)0Direct
Resistin0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000002091Direct
Complement components0.00003653Direct
Alpha-macroglobulin receptor domain0.00003653Direct
Pyrin domain, PYD0.00003653Direct
Integrin beta tail domain0.00003653Direct
Integrin beta EGF-like domains0.0001966Direct
VWC domain0.001738Inherited
Nuclear receptor ligand-binding domain0.009372Inherited
Nuclear receptor0.009372Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.01741Inherited
Noncollagenous (NC1) domain of collagen IV0.0271Inherited
Matrix metalloproteases, catalytic domain0.04219Inherited
Hemopexin-like domain0.04219Inherited
MMP N-terminal domain0.04219Inherited
Rhodopsin-like0.07681Inherited
Transforming growth factor (TGF)-beta0.119Inherited
Short-chain cytokines0.1313Inherited
Interleukin 17F, IL-17F0.1384Inherited
Interferons/interleukin-10 (IL-10)0.2296Inherited
Ngr ectodomain-like0.2393Inherited
28-residue LRR0.3001Inherited
Papain-like0.3122Inherited
RING finger domain, C3HC40.3441Inherited
PLC-like (P variant)0.3474Inherited
TNF-like0.3799Inherited
Toll/Interleukin receptor TIR domain0.5376Inherited
TNF receptor-like0.6317Inherited
Nicotinic receptor ligand binding domain-like0.7592Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7592Inherited
Caspase recruitment domain, CARD0.8517Inherited
V set domains (antibody variable domain-like)0.9262Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Resistin0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Anaphylotoxins (complement system)0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Alpha-macroglobulin receptor domain0.0000229Direct
Integrin beta tail domain0.0000229Direct
EGF/Laminin0.0006957Direct
p53-like transcription factors0.000802Direct
Terpenoid cyclases/Protein prenyltransferases0.001007Inherited
Nuclear receptor ligand-binding domain0.006261Inherited
Riboflavin synthase domain-like0.0114Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0114Inherited
Hemopexin-like domain0.03298Inherited
PGBD-like0.03298Inherited
Cystine-knot cytokines0.03572Inherited
L30e-like0.05829Inherited
4-helical cytokines0.05977Inherited
Family A G protein-coupled receptor-like0.0639Inherited
RNI-like0.08145Inherited
Growth factor receptor domain0.08936Inherited
Kringle-like0.1483Inherited
Cytokine0.3047Inherited
TNF-like0.3262Inherited
DEATH domain0.3397Inherited
Toll/Interleukin receptor TIR domain0.4136Inherited
TNF receptor-like0.6018Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7091Inherited
Nicotinic receptor ligand binding domain-like0.7091Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52047,52058
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00000009828Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0000229Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0001281Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0001281Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0005928Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.01485Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.02203Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.03298Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04591Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07932Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.646Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.7091Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9785Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0000229Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0006544Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0006544Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1221Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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