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Mammalian Phenotype (MP): abnormal reproductive system physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   reproductive system phenotype [MP:0005389] <2>(38|58) (47|18|6)
0:   abnormal reproductive system physiology [MP:0001919] <10>(21|39) (27|11|2)
- 1:   abnormal female reproductive system physiology [MP:0003699] <13>(10|24) (17|6|2)
- 1:   abnormal male reproductive system physiology [MP:0003698] <12>(4|8) (4|4|0)
- 1:   reproductive system inflammation [MP:0002254] <8>(0|0) (0|0|0)
- 1:   abnormal fertility/fecundity [MP:0002161] <7>(8|20) (10|3|0)
- 1:   abnormal germ cell physiology [MP:0020363] <5>(0|0) (0|0|0)
- 1:   abnormal fertilization [MP:0005410] <4>(2|2) (2|1|0)
- 1:   abnormal sex gland physiology [MP:0005647] <4>(1|2) (2|1|0)
- 1:   genital hemorrhage [MP:0004245] <2>(1|2) (2|0|0)
- 1:   abnormal copulation [MP:0009697] <1>(0|0) (0|0|0)
- 1:   genital discharge [MP:0013136](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0.00003352Direct
PAZ domain0.006527Inherited
The spindle assembly checkpoint protein mad20.009397Inherited
HMA, heavy metal-associated domain0.009397Inherited
Flavoproteins0.01919Inherited
Nuclear receptor ligand-binding domain0.02423Inherited
Nucleic acid-binding proteins0.08221Inherited
Alpha-macroglobulin receptor domain0.08472Inherited
PYP-like sensor domain (PAS domain)0.08523Inherited
SMAD/FHA domain0.1077Inherited
Metalloproteases ("zincins"), catalytic domain0.1087Inherited
Blood coagulation inhibitor (disintegrin)0.1204Inherited
4-helical cytokines0.1283Inherited
Alkaline phosphatase-like0.1718Inherited
Terpenoid cyclases/Protein prenyltransferases0.2047Inherited
E2F-DP heterodimerization region0.5367Inherited
Tudor/PWWP/MBT0.5422Inherited
EGF/Laminin0.8862Inherited
Fibronectin type III0.919Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 DNA-binding domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
SMAD MH1 domain0.00002059Direct
SMAD domain0.00002059Direct
Linker histone H1/H50.001423Inherited
Gonadodropin/Follitropin0.001668Inherited
NADPH-cytochrome p450 reductase-like0.001668Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001668Inherited
PAZ domain0.004698Inherited
The spindle assembly checkpoint protein mad20.006651Inherited
DNA gyrase/MutL, second domain0.006651Inherited
Neurotrophin0.006651Inherited
DNA gyrase/MutL, N-terminal domain0.006651Inherited
gamma-adaptin C-terminal appendage domain-like0.006651Inherited
HMA, heavy metal-associated domain0.006651Inherited
STAT DNA-binding domain0.01442Inherited
Single strand DNA-binding domain, SSB0.01442Inherited
Transcription factor STAT-4 N-domain0.01442Inherited
STAT0.01442Inherited
Nuclear receptor ligand-binding domain0.01862Inherited
Nuclear receptor0.02499Inherited
Long-chain cytokines0.02634Inherited
Astacin0.04133Inherited
Complement components0.06918Inherited
Alpha-macroglobulin receptor domain0.06918Inherited
Blood coagulation inhibitor (disintegrin)0.1042Inherited
Tudor domain0.1648Inherited
Reprolysin-like0.2879Inherited
Short-chain cytokines0.3319Inherited
E2F dimerization segment0.5041Inherited
Ngr ectodomain-like0.5502Inherited
Transforming growth factor (TGF)-beta0.7369Inherited
EGF-type module0.7684Inherited
I set domains0.8738Inherited
Fibronectin type III0.9097Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0.00001545Direct
PAZ domain0.003978Inherited
The spindle assembly checkpoint protein mad20.005847Inherited
HMA, heavy metal-associated domain0.005847Inherited
STAT0.01254Inherited
Flavoproteins0.01254Inherited
Transcription factor STAT-4 N-domain0.01254Inherited
Nuclear receptor ligand-binding domain0.01614Inherited
Nucleic acid-binding proteins0.06084Inherited
Alpha-macroglobulin receptor domain0.0629Inherited
PYP-like sensor domain (PAS domain)0.06329Inherited
SMAD/FHA domain0.082Inherited
Metalloproteases ("zincins"), catalytic domain0.08286Inherited
Blood coagulation inhibitor (disintegrin)0.09286Inherited
4-helical cytokines0.09967Inherited
Alkaline phosphatase-like0.1378Inherited
Terpenoid cyclases/Protein prenyltransferases0.1675Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2707Inherited
L domain-like0.474Inherited
E2F-DP heterodimerization region0.4897Inherited
Tudor/PWWP/MBT0.4953Inherited
EGF/Laminin0.8581Inherited
Family A G protein-coupled receptor-like0.8673Inherited
Fibronectin type III0.8938Inherited
Immunoglobulin1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01254Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01254Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01254Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.01816Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02052Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.08591Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.09286Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.09367Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.4897Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8683Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01254Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01254Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)