SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal tumor incidence

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ 1:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
0:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
- 1:   abnormal classified tumor incidence [MP:0020188] <3>(20|19) (26|7|1)
- 1:   decreased tumor incidence [MP:0002052] <3>(0|1) (0|1|0)
- 1:   increased tumor incidence [MP:0002020] <3>(25|27) (30|10|3)
- 1:   abnormal incidence of induced tumors [MP:0013151] <2>(1|1) (1|1|0)
- 1:   abnormal organ/body region tumor incidence [MP:0013152] <2>(21|24) (24|8|3)
- 1:   embryo tumor [MP:0014018](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.00002013Direct
DNA/RNA polymerases0.00007402Direct
Bcl-2 inhibitors of programmed cell death0.0009142Direct
DNA-glycosylase0.001403Inherited
Restriction endonuclease-like0.001403Inherited
SPOC domain-like0.001403Inherited
Nucleic acid-binding proteins0.001615Inherited
4-helical cytokines0.002026Inherited
RING/U-box0.00451Inherited
DNA repair protein MutS, domain III0.004618Inherited
Notch domain0.004618Inherited
SAND domain-like0.004618Inherited
Putative DNA-binding domain0.01741Inherited
BRCT domain0.0276Inherited
CCCH zinc finger0.08512Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.111Inherited
SET domain0.1409Inherited
ARM repeat0.149Inherited
Ubiquitin-like0.373Inherited
Protein kinase-like (PK-like)0.4234Inherited
Intermediate filament protein, coiled coil region0.4788Inherited
SMAD/FHA domain0.902Inherited
Cyclin-like0.9317Inherited
p53-like transcription factors0.9317Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
SMAD domain0.00001487Direct
SMAD MH1 domain0.00001487Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.00001487Direct
DNA polymerase I0.0006224Direct
Bcl-2 inhibitors of programmed cell death0.00071Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001016Inherited
XPF/Rad1/Mus81 nuclease0.001022Inherited
Pointed domain0.001629Inherited
L domain0.001629Inherited
Notch domain0.003553Inherited
DNA repair protein MutS, domain III0.003553Inherited
p120GAP domain-like0.009654Inherited
Forkhead DNA-binding domain0.01208Inherited
Pyrin domain, PYD0.01424Inherited
Single strand DNA-binding domain, SSB0.01424Inherited
DnaQ-like 3'-5' exonuclease0.02025Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.02678Inherited
Short-chain cytokines0.02725Inherited
Interferons/interleukin-10 (IL-10)0.03294Inherited
Histone lysine methyltransferases0.0499Inherited
CCCH zinc finger0.0757Inherited
FHA domain0.1262Inherited
Protein kinases, catalytic subunit0.4185Inherited
Phosphotyrosine-binding domain (PTB)0.4434Inherited
Intermediate filament protein, coiled coil region0.4842Inherited
ABC transporter ATPase domain-like0.4992Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000008999Direct
DNA/RNA polymerases0.00003536Direct
Bcl-2 inhibitors of programmed cell death0.0004967Direct
Restriction endonuclease-like0.0007829Direct
SPOC domain-like0.0007829Direct
DNA-glycosylase0.0007829Direct
Nucleic acid-binding proteins0.0009074Direct
4-helical cytokines0.001152Inherited
RING/U-box0.002677Inherited
DNA repair protein MutS, domain III0.00275Inherited
Notch domain0.00275Inherited
SAND domain-like0.00275Inherited
Chromo domain-like0.005298Inherited
Snake toxin-like0.00771Inherited
Putative DNA-binding domain0.01135Inherited
BRCT domain0.01862Inherited
Cysteine-rich domain0.02392Inherited
Ribonuclease H-like0.04478Inherited
CCCH zinc finger0.06322Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.08496Inherited
Leucine zipper domain0.09669Inherited
SET domain0.1106Inherited
ARM repeat0.1178Inherited
Ubiquitin-like0.327Inherited
Protein kinase-like (PK-like)0.3766Inherited
Intermediate filament protein, coiled coil region0.4313Inherited
SMAD/FHA domain0.8752Inherited
Cyclin-like0.9078Inherited
p53-like transcription factors0.9078Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0007335Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0007829Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001198Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001198Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.002505Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00275Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01826Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.02149Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.04521Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1343Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0007829Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001198Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0781Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)