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Mammalian Phenotype (MP): increased tumor incidence

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + 2:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ 1:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
0:   increased tumor incidence [MP:0002020] <3>(25|27) (30|10|3)
- 1:   increased classified tumor incidence [MP:0010273] <19>(20|19) (26|7|1)
- 1:   increased organ/body region tumor incidence [MP:0010274] <14>(21|24) (24|8|3)
- 1:   increased incidence of induced tumors [MP:0002021] <4>(1|0) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000008991Direct
DNA/RNA polymerases0.00003168Direct
Bcl-2 inhibitors of programmed cell death0.0005051Direct
Nucleic acid-binding proteins0.0006004Direct
DNA-glycosylase0.0009418Direct
Restriction endonuclease-like0.0009418Direct
SPOC domain-like0.0009418Direct
SMAD/FHA domain0.00096Direct
Cyclin-like0.002385Inherited
DNA repair protein MutS, domain III0.003135Inherited
Notch domain0.003135Inherited
SAND domain-like0.003135Inherited
Putative DNA-binding domain0.0123Inherited
BRCT domain0.01634Inherited
p53-like transcription factors0.0478Inherited
CCCH zinc finger0.0632Inherited
SET domain0.09114Inherited
ARM repeat0.1687Inherited
Protein kinase-like (PK-like)0.1703Inherited
RING/U-box0.3007Inherited
4-helical cytokines0.4161Inherited
Intermediate filament protein, coiled coil region0.738Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8397Inherited
Ubiquitin-like0.9901Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
SMAD domain0.000006685Direct
SMAD MH1 domain0.000006685Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.000006685Direct
DNA polymerase I0.0003708Direct
Bcl-2 inhibitors of programmed cell death0.0003873Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0005148Direct
XPF/Rad1/Mus81 nuclease0.0006709Direct
Pointed domain0.0009831Direct
L domain0.0009831Direct
Notch domain0.002362Inherited
DNA repair protein MutS, domain III0.002362Inherited
Forkhead DNA-binding domain0.005659Inherited
p120GAP domain-like0.006098Inherited
Single strand DNA-binding domain, SSB0.009892Inherited
DnaQ-like 3'-5' exonuclease0.01318Inherited
Short-chain cytokines0.01805Inherited
Histone lysine methyltransferases0.03166Inherited
CCCH zinc finger0.05529Inherited
FHA domain0.09007Inherited
Protein kinases, catalytic subunit0.2033Inherited
Phosphotyrosine-binding domain (PTB)0.3529Inherited
ABC transporter ATPase domain-like0.3922Inherited
Intermediate filament protein, coiled coil region0.7063Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.829Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000003919Direct
DNA/RNA polymerases0.00001455Direct
Bcl-2 inhibitors of programmed cell death0.0002669Direct
Nucleic acid-binding proteins0.0003186Direct
Restriction endonuclease-like0.0005115Direct
SPOC domain-like0.0005115Direct
DNA-glycosylase0.0005115Direct
SMAD/FHA domain0.0005226Direct
Cyclin-like0.001367Inherited
DNA repair protein MutS, domain III0.001825Inherited
Notch domain0.001825Inherited
SAND domain-like0.001825Inherited
Chromo domain-like0.002655Inherited
Putative DNA-binding domain0.007808Inherited
BRCT domain0.01058Inherited
Ribonuclease H-like0.02681Inherited
p53-like transcription factors0.03367Inherited
CCCH zinc finger0.04578Inherited
SET domain0.0682Inherited
ARM repeat0.135Inherited
Protein kinase-like (PK-like)0.1364Inherited
RING/U-box0.2574Inherited
4-helical cytokines0.369Inherited
Leucine zipper domain0.4854Inherited
Snake toxin-like0.4854Inherited
Intermediate filament protein, coiled coil region0.6993Inherited
Cysteine-rich domain0.7849Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8079Inherited
Ubiquitin-like0.9749Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0002715Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0005115Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0007204Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0007204Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001825Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0126Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.01391Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.09605Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.6993Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0005115Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0007204Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.05696Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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