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Mammalian Phenotype (MP): abnormal skin morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   integument phenotype [MP:0010771] <5>(46|64) (53|34|18)
0:   abnormal skin morphology [MP:0002060] <16>(19|26) (24|13|8)
- 1:   abnormal skin appearance [MP:0009931] <17>(7|12) (9|5|2)
- 1:   abnormal epidermal layer morphology [MP:0001216] <15>(9|11) (11|5|3)
- 1:   abnormal skin condition [MP:0001191] <14>(1|2) (1|0|0)
- 1:   abnormal dermal layer morphology [MP:0001243] <9>(1|2) (1|0|1)
- 1:   increased skin tumor incidence [MP:0010300] <9>(3|3) (6|1|0)
- 1:   abnormal skin development [MP:0003941] <4>(0|1) (1|0|0)
- 1:   skin hemorrhage [MP:0011514] <3>(2|1) (2|0|0)
- 1:   abnormal skin cell number [MP:0001213] <2>(0|0) (0|0|0)
- 1:   abnormal cutaneous elastic fiber morphology [MP:0008418] <1>(1|0) (1|1|0)
- 1:   abnormal epidermal-dermal junction morphology [MP:0011159] <1>(2|1) (2|1|0)
- 1:   abnormal skin coloration [MP:0011239] <1>(0|0) (1|1|0)
- 1:   abnormal cutaneous collagen fibril morphology [MP:0008438](1|1) (1|0|0)
- 1:   calcified skin [MP:0003196](0|0) (0|0|0)
- 1:   decreased skin tumor incidence [MP:0010285](0|0) (0|0|0)
- 1:   dyskeratosis [MP:0009563](0|0) (0|0|0)
- 1:   skin fibrosis [MP:0009932](0|0) (0|0|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Notch domain0.0003231Direct
CalX-like0.006218Inherited
DNA repair protein MutS, domain III0.006342Inherited
EGF/Laminin0.02201Inherited
PAZ domain0.03583Inherited
Intermediate filament protein, coiled coil region0.05828Inherited
Integrin beta tail domain0.07799Inherited
FnI-like domain0.1307Inherited
Integrin domains0.134Inherited
TNF receptor-like0.1912Inherited
Leucine zipper domain0.193Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2624Inherited
p53-like transcription factors0.2973Inherited
vWA-like0.3136Inherited
Growth factor receptor domain0.3168Inherited
Cadherin-like0.3915Inherited
C-type lectin-like0.7232Inherited
Nuclear receptor ligand-binding domain0.7698Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Lamin A/C globular tail domain0Direct
Notch domain0.0002086Direct
DNA repair protein MutS, domain III0.004557Inherited
CalX-beta domain0.004558Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.01789Inherited
VWC domain0.02215Inherited
PAZ domain0.02805Inherited
EGF-type module0.03265Inherited
Laminin-type module0.03634Inherited
Intermediate filament protein, coiled coil region0.04326Inherited
Integrin beta tail domain0.0595Inherited
Integrin beta EGF-like domains0.0595Inherited
Integrin domains0.1077Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1591Inherited
TNF receptor-like0.1591Inherited
Leucine zipper domain0.1608Inherited
Ankyrin repeat0.1755Inherited
Ngr ectodomain-like0.1844Inherited
Integrin A (or I) domain0.2436Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2936Inherited
Cadherin0.3518Inherited
Papain-like0.504Inherited
C-type lectin domain0.6172Inherited
Nuclear receptor ligand-binding domain0.7371Inherited
Nuclear receptor0.7371Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Notch domain0.0001675Direct
CalX-like0.003775Inherited
DNA repair protein MutS, domain III0.003855Inherited
EGF/Laminin0.01457Inherited
PAZ domain0.02467Inherited
Intermediate filament protein, coiled coil region0.04182Inherited
Integrin beta tail domain0.05747Inherited
FnI-like domain0.1018Inherited
Integrin domains0.1047Inherited
TNF receptor-like0.1554Inherited
Leucine zipper domain0.157Inherited
Ankyrin repeat0.1717Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2212Inherited
p53-like transcription factors0.2542Inherited
vWA-like0.2697Inherited
Cysteine-rich domain0.2717Inherited
Growth factor receptor domain0.2727Inherited
DNA/RNA polymerases0.3269Inherited
Cadherin-like0.3451Inherited
WD40 repeat-like0.4684Inherited
Cyclin-like0.6422Inherited
C-type lectin-like0.6836Inherited
Nuclear receptor ligand-binding domain0.7326Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.001116Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003855Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01545Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03501Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03833Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.04571Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.05747Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.09376Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.1515Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.3269Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3451Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.7378Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.000706Direct
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.001116Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.001836Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01545Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.05747Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.05747Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3451Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4055Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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