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Mammalian Phenotype (MP): abnormal glucose homeostasis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ 1:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
0:   abnormal glucose homeostasis [MP:0002078] <14>(15|22) (17|17|8)
- 1:   abnormal circulating glucose level [MP:0000188] <3>(6|11) (6|7|3)
- 1:   abnormal circulating glucagon level [MP:0002695] <2>(0|0) (0|0|0)
- 1:   abnormal circulating insulin level [MP:0001560] <2>(4|6) (5|8|3)
- 1:   abnormal glucagon secretion [MP:0003565] <2>(0|0) (0|0|0)
- 1:   abnormal glucose tolerance [MP:0005291] <2>(0|6) (2|9|8)
- 1:   abnormal glycogen homeostasis [MP:0005438] <2>(5|3) (6|3|1)
- 1:   abnormal hepatic glucose production [MP:0020101] <2>(0|0) (0|0|0)
- 1:   abnormal insulin secretion [MP:0003564] <2>(1|4) (1|1|0)
- 1:   abnormal urine glucose level [MP:0001758] <2>(0|0) (0|0|0)
- 1:   abnormal gluconeogenesis [MP:0003383](0|1) (0|1|0)
- 1:   abnormal insulin clearance [MP:0003839](0|0) (0|0|0)
- 1:   abnormal renal glucose reabsorption [MP:0011447](0|0) (0|0|0)
- 1:   increased insulin sensitivity [MP:0002891](0|0) (0|0|0)
- 1:   insulin resistance [MP:0005331](0|0) (0|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
KA1-like0.01765Inherited
Insulin-like0.02419Inherited
GAT-like domain0.0422Inherited
ClpP/crotonase0.05169Inherited
Transcription factor STAT-4 N-domain0.05169Inherited
STAT0.05169Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.06013Inherited
Galactose mutarotase-like0.105Inherited
Clathrin adaptor appendage domain0.1808Inherited
(Trans)glycosidases0.2399Inherited
Protein kinase-like (PK-like)0.2483Inherited
ENTH/VHS domain0.258Inherited
Thyroglobulin type-1 domain0.258Inherited
Glycosyl hydrolase domain0.2629Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Carboxylesterase0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
IP3 receptor type 1 binding core, domain 20Direct
GAT domain0.002362Inherited
Kinase associated domain 1, KA10.002362Inherited
Phosphotyrosine-binding domain (PTB)0.003105Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.008101Inherited
Insulin-like0.01587Inherited
Chaperone J-domain0.02417Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.02424Inherited
VHS domain0.02912Inherited
gamma-adaptin C-terminal appendage domain-like0.02924Inherited
STAT0.03598Inherited
Transcription factor STAT-4 N-domain0.03598Inherited
STAT DNA-binding domain0.03598Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.07421Inherited
L domain0.1442Inherited
Papain-like0.1655Inherited
Thyroglobulin type-1 domain0.2254Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.2457Inherited
Growth factor receptor domain0.3229Inherited
Forkhead DNA-binding domain0.3252Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
KA1-like0.01149Inherited
Insulin-like0.01613Inherited
Chaperone J-domain0.02547Inherited
GAT-like domain0.02942Inherited
ClpP/crotonase0.03658Inherited
t-snare proteins0.03658Inherited
Transcription factor STAT-4 N-domain0.03658Inherited
STAT0.03658Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.04332Inherited
Galactose mutarotase-like0.07975Inherited
Clathrin adaptor appendage domain0.1459Inherited
(Trans)glycosidases0.2004Inherited
Protein kinase-like (PK-like)0.2082Inherited
Thyroglobulin type-1 domain0.2172Inherited
ENTH/VHS domain0.2172Inherited
Glycosyl hydrolase domain0.2217Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.01553Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.02929Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.02942Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.02942Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.03658Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.03658Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03658Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03658Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.07536Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.07975Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.126Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1312Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.1459Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1459Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.2217Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03658Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03658Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.07536Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1459Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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