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Mammalian Phenotype (MP): prenatal lethality

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   mortality/aging [MP:0010768] <4>(83|115) (89|67|50)
+ 1:   preweaning lethality [MP:0010770] <4>(48|79) (55|45|38)
+ 1:   abnormal survival [MP:0010769] <10>(60|91) (67|55|39)
0:   prenatal lethality [MP:0002080] <5>(27|49) (30|23|16)
- 1:   embryonic lethality [MP:0008762] <4>(16|30) (16|11|7)
- 1:   lethality throughout fetal growth and development [MP:0006208] <2>(5|8) (6|6|7)
- 1:   prenatal lethality prior to heart atrial septation [MP:0013294](0|0) (0|0|0)
- 1:   prenatal lethality, complete penetrance [MP:0011091](0|2) (0|0|0)
- 1:   prenatal lethality, incomplete penetrance [MP:0011101](2|5) (4|1|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
ATP-dependent DNA ligase DNA-binding domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
p53 tetramerization domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Zinc beta-ribbon0Direct
GroEL-intermediate domain like0Direct
Ribonuclease PH domain 2-like0Direct
"Winged helix" DNA-binding domain0.0007803Direct
ARM repeat0.001415Inherited
Nucleic acid-binding proteins0.003415Inherited
GroEL apical domain-like0.01053Inherited
HCP-like0.01347Inherited
Protein kinase-like (PK-like)0.01609Inherited
BRCT domain0.01698Inherited
SCOP hierarchy in SUPERFAMILY0.02142Inherited
E2F-DP heterodimerization region0.05363Inherited
Flavoproteins0.06525Inherited
p53-like transcription factors0.08255Inherited
DNA clamp0.1279Inherited
SMAD MH1 domain0.1428Inherited
ADC-like0.1947Inherited
Subtilisin-like0.2014Inherited
Cullin homology domain0.2014Inherited
TB module/8-cys domain0.2797Inherited
dsRNA-binding domain-like0.3325Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Chromo barrel domain0Direct
Pointed domain0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
p53 DNA-binding domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Ribonuclease PH domain 1-like0Direct
SMAD4-binding domain of oncoprotein Ski0Direct
DNA ligase0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
ATP-dependent DNA ligase catalytic domain0Direct
Fumble-like0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Ribonuclease PH domain 2-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
SIAH, seven in absentia homolog0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.0002667Direct
RecA protein-like (ATPase-domain)0.0005902Direct
Inhibitor of apoptosis (IAP) repeat0.002491Inherited
Extracellular domain of cell surface receptors0.003997Inherited
ets domain0.004541Inherited
NADPH-cytochrome p450 reductase-like0.007336Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.007336Inherited
N-acetyl transferase, NAT0.00854Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.00854Inherited
Cell cycle transcription factor e2f-dp0.01409Inherited
Histone lysine methyltransferases0.01747Inherited
C5 cytosine-specific DNA methylase, DCM0.02073Inherited
Proprotein convertase P-domain0.02397Inherited
Prohormone convertase 1 pro-domain0.02397Inherited
DNA polymerase I0.02397Inherited
Erythroid transcription factor GATA-10.03788Inherited
Protein kinases, catalytic subunit0.03801Inherited
Adenain-like0.05773Inherited
Subtilases0.06162Inherited
E2F dimerization segment0.06162Inherited
Tandem AAA-ATPase domain0.08221Inherited
SCF ubiquitin ligase complex WHB domain0.09977Inherited
SMAD MH1 domain0.1118Inherited
SMAD domain0.1118Inherited
Extended AAA-ATPase domain0.1322Inherited
Linker histone H1/H50.1326Inherited
Cullin homology domain0.1641Inherited
T-box0.1679Inherited
TB module/8-cys domain0.2369Inherited
Armadillo repeat0.2515Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.75Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Ribonuclease PH domain 2-like0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
GroEL-intermediate domain like0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
Zinc beta-ribbon0Direct
p53 tetramerization domain0Direct
"Winged helix" DNA-binding domain0.0004204Direct
ARM repeat0.0007897Direct
Nucleic acid-binding proteins0.001993Inherited
GroEL apical domain-like0.006602Inherited
HCP-like0.008587Inherited
Inhibitor of apoptosis (IAP) repeat0.008587Inherited
Protein kinase-like (PK-like)0.01039Inherited
BRCT domain0.01103Inherited
E2F-DP heterodimerization region0.0381Inherited
Flavoproteins0.04739Inherited
Acyl-CoA N-acyltransferases (Nat)0.05347Inherited
p53-like transcription factors0.06111Inherited
DNA clamp0.09933Inherited
SMAD MH1 domain0.1123Inherited
ADC-like0.1585Inherited
Cullin homology domain0.1645Inherited
Subtilisin-like0.1645Inherited
Riboflavin synthase domain-like0.2273Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2273Inherited
TB module/8-cys domain0.2377Inherited
dsRNA-binding domain-like0.2878Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02076Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0214Inherited
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.02198Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0381Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.05385Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0844Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.09933Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.09933Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.09933Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.1585Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.1645Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3389Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.3912Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.3912Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02076Inherited
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02076Inherited
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.02198Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.05385Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.09933Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1585Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.1585Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3389Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.3912Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)