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Mammalian Phenotype (MP): abnormal eye morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   vision/eye phenotype [MP:0005391] <2>(43|53) (50|27|17)
0:   abnormal eye morphology [MP:0002092] <23>(39|49) (46|25|15)
- 1:   abnormal eye development [MP:0001286] <22>(6|5) (6|2|2)
- 1:   abnormal eyelid morphology [MP:0001340] <21>(4|8) (6|5|1)
- 1:   abnormal anterior eye segment morphology [MP:0005193] <10>(13|13) (14|4|0)
- 1:   abnormal eye pigmentation [MP:0001324] <8>(1|1) (2|0|1)
- 1:   abnormal eye distance/ position [MP:0001299] <5>(0|0) (0|0|0)
- 1:   abnormal eye muscle morphology [MP:0003686] <4>(1|1) (1|0|0)
- 1:   abnormal ocular surface morphology [MP:0013754] <4>(0|1) (2|0|0)
- 1:   abnormal posterior eye segment morphology [MP:0005195] <4>(21|24) (23|14|8)
- 1:   abnormal eye size [MP:0002697] <3>(3|5) (4|2|1)
- 1:   abnormal orbit morphology [MP:0010030] <3>(0|0) (0|0|0)
- 1:   abnormal uvea morphology [MP:0005197] <3>(10|7) (10|5|1)
- 1:   abnormal sclera morphology [MP:0002698] <2>(2|2) (2|1|0)
- 1:   increased eye tumor incidence [MP:0010295] <2>(1|1) (1|0|0)
- 1:   strabismus [MP:0005254] <2>(0|0) (0|0|0)
- 1:   calcified intraocular region [MP:0006209] <1>(0|0) (0|0|0)
- 1:   abnormal cornea limbus morphology [MP:0013477](0|0) (0|0|0)
- 1:   anophthalmia [MP:0001293](0|0) (0|0|0)
- 1:   decreased eye tumor incidence [MP:0012418](0|0) (0|0|0)
- 1:   eye lesions [MP:0013146](0|0) (0|0|0)
- 1:   eye opacity [MP:0009859](0|0) (0|0|0)
- 1:   eye swellings [MP:0013170](0|0) (0|0|0)
- 1:   ocular rupture [MP:0006225](0|0) (0|0|0)
- 1:   periorbital edema [MP:0001788](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Notch domain0Direct
Tubby C-terminal domain-like0Direct
p53 tetramerization domain0Direct
Di-copper centre-containing domain0Direct
gamma-Crystallin-like0.0000007709Direct
Plexin repeat0.0002206Direct
HLH, helix-loop-helix DNA-binding domain0.00126Inherited
Sema domain0.006134Inherited
Nuclear receptor ligand-binding domain0.01269Inherited
GroEL equatorial domain-like0.01965Inherited
TNF-like0.03803Inherited
GAF domain-like0.03911Inherited
Homeodomain-like0.04834Inherited
HMG-box0.06135Inherited
Cupredoxins0.06409Inherited
E2F-DP heterodimerization region0.06419Inherited
PGBD-like0.06602Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.06858Inherited
Clc chloride channel0.09376Inherited
Integrin domains0.1105Inherited
Cyclin-like0.1284Inherited
CBS-domain pair0.1293Inherited
Kringle-like0.1386Inherited
Tetraspanin0.1883Inherited
"Winged helix" DNA-binding domain0.2176Inherited
Metalloproteases ("zincins"), catalytic domain0.256Inherited
HD-domain/PDEase-like0.3201Inherited
Blood coagulation inhibitor (disintegrin)0.3201Inherited
Toll/Interleukin receptor TIR domain0.4575Inherited
FnI-like domain0.5465Inherited
Cystine-knot cytokines0.6717Inherited
L domain-like0.692Inherited
EGF/Laminin0.6988Inherited
DBL homology domain (DH-domain)0.7302Inherited
CalX-like0.8043Inherited
Trypsin-like serine proteases0.9942Inherited
Nicotinic receptor ligand binding domain-like1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 DNA-binding domain-like0Direct
Transcriptional factor tubby, C-terminal domain0Direct
Notch domain0Direct
p53 tetramerization domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Crystallins/Ca-binding development proteins0.0000004802Direct
Forkhead DNA-binding domain0.00003896Direct
Arylsulfatase0.00005566Direct
Plexin repeat0.000161Direct
I set domains0.0005034Direct
HLH, helix-loop-helix DNA-binding domain0.001086Inherited
YWTD domain0.003836Inherited
Noncollagenous (NC1) domain of collagen IV0.004024Inherited
Sema domain0.004741Inherited
Laminin-type module0.005578Inherited
Nuclear receptor0.00693Inherited
Nuclear receptor ligand-binding domain0.01046Inherited
Extracellular domain of cell surface receptors0.01094Inherited
E2F dimerization segment0.03018Inherited
GAF domain0.03018Inherited
TNF-like0.03155Inherited
Homeodomain0.04769Inherited
HMG-box0.05249Inherited
MMP N-terminal domain0.05465Inherited
Matrix metalloproteases, catalytic domain0.06898Inherited
Clc chloride channel0.07732Inherited
CBS-domain pair0.08625Inherited
TNF receptor-like0.08718Inherited
Integrin domains0.09614Inherited
Cell cycle transcription factor e2f-dp0.1075Inherited
Kringle modules0.1373Inherited
PDEase0.2292Inherited
POU-specific domain0.2292Inherited
Blood coagulation inhibitor (disintegrin)0.2965Inherited
cAMP-binding domain0.3554Inherited
PDZ domain0.4267Inherited
Cyclin0.4935Inherited
Transforming growth factor (TGF)-beta0.5023Inherited
EGF-type module0.5283Inherited
VWC domain0.6228Inherited
DBL homology domain (DH-domain)0.7186Inherited
CalX-beta domain0.7715Inherited
Ngr ectodomain-like0.8048Inherited
Calmodulin-like0.9508Inherited
Eukaryotic proteases0.9985Inherited
Nicotinic receptor ligand binding domain-like1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Notch domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Di-copper centre-containing domain0Direct
Tubby C-terminal domain-like0Direct
gamma-Crystallin-like0.0000003124Direct
Plexin repeat0.0001119Direct
Alkaline phosphatase-like0.0005938Direct
HLH, helix-loop-helix DNA-binding domain0.0006976Direct
Integrin beta tail domain0.0008505Direct
YWTD domain0.003145Inherited
Sema domain0.00372Inherited
Nuclear receptor ligand-binding domain0.008069Inherited
GroEL equatorial domain-like0.01287Inherited
TNF-like0.0263Inherited
GAF domain-like0.02708Inherited
Homeodomain-like0.03406Inherited
HMG-box0.0443Inherited
Cupredoxins0.0465Inherited
E2F-DP heterodimerization region0.04656Inherited
PGBD-like0.04801Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.05009Inherited
Clc chloride channel0.07034Inherited
Integrin domains0.08453Inherited
beta-sandwich domain of Sec23/240.09856Inherited
Cyclin-like0.09978Inherited
CBS-domain pair0.1005Inherited
Kringle-like0.1087Inherited
Tetraspanin0.1527Inherited
TNF receptor-like0.164Inherited
"Winged helix" DNA-binding domain0.1796Inherited
Metalloproteases ("zincins"), catalytic domain0.2153Inherited
Blood coagulation inhibitor (disintegrin)0.2761Inherited
HD-domain/PDEase-like0.2761Inherited
Toll/Interleukin receptor TIR domain0.4097Inherited
Growth factor receptor domain0.456Inherited
FnI-like domain0.4998Inherited
Cystine-knot cytokines0.6296Inherited
L domain-like0.6507Inherited
EGF/Laminin0.6578Inherited
Intermediate filament protein, coiled coil region0.6843Inherited
DBL homology domain (DH-domain)0.6912Inherited
CalX-like0.7696Inherited
Trypsin-like serine proteases0.9798Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9974Inherited
Nicotinic receptor ligand binding domain-like0.9974Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0008505Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001674Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.003003Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.00372Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.004545Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.008317Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.008317Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01597Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.02708Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.02708Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.04656Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.04801Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.07034Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.07792Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.1816Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2113Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.216Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.2761Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.309Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.649Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.9974Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    49265,48726,49265
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000005515Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0008505Direct
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.003442Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.008917Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01287Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01287Inherited
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01597Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.02708Inherited
    50156,50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.04656Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.5878Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.691Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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