SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal muscle morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   muscle phenotype [MP:0005369] <2>(49|57) (54|37|28)
0:   abnormal muscle morphology [MP:0002108] <16>(28|31) (31|22|21)
- 1:   abnormal skeletal muscle morphology [MP:0000759] <25>(15|15) (16|9|5)
- 1:   abnormal smooth muscle morphology [MP:0000767] <13>(6|6) (6|1|0)
- 1:   abnormal muscle development [MP:0000733] <7>(1|2) (1|0|0)
- 1:   abnormal muscle fiber morphology [MP:0004087] <7>(4|6) (5|7|6)
- 1:   abnormal cardiac muscle tissue morphology [MP:0010630] <5>(2|3) (2|0|3)
- 1:   abnormal eye muscle morphology [MP:0003686] <4>(1|1) (1|0|0)
- 1:   increased muscle tumor incidence [MP:0010290] <4>(0|0) (0|0|0)
- 1:   muscular atrophy [MP:0002269] <4>(0|0) (0|0|0)
- 1:   abnormal muscle weight [MP:0004233] <3>(3|2) (3|0|0)
- 1:   abnormal tendon morphology [MP:0005503] <3>(2|3) (3|0|0)
- 1:   abnormal muscle glycogen level [MP:0014068] <2>(1|0) (1|0|0)
- 1:   muscle degeneration [MP:0000749] <2>(1|1) (1|0|0)
- 1:   decreased muscle tumor incidence [MP:0012413] <1>(0|0) (0|0|0)
- 1:   muscle hypoplasia [MP:0000734] <1>(0|0) (0|0|0)
- 1:   calcified muscle [MP:0003199](0|0) (0|0|0)
- 1:   dystrophic muscle [MP:0000752](0|1) (0|2|1)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Troponin coil-coiled subunits0Direct
Lamin A/C globular tail domain0Direct
TB module/8-cys domain0.00004759Direct
HLH, helix-loop-helix DNA-binding domain0.0001431Direct
Growth factor receptor domain0.001189Inherited
SRF-like0.002197Inherited
Flavoproteins0.003611Inherited
Homeodomain-like0.006682Inherited
Cystine-knot cytokines0.01423Inherited
B-box zinc-binding domain0.06657Inherited
BPTI-like0.07364Inherited
Kazal-type serine protease inhibitors0.1132Inherited
Clavaminate synthase-like0.1483Inherited
"Winged helix" DNA-binding domain0.2425Inherited
Metalloproteases ("zincins"), catalytic domain0.2497Inherited
alpha-catenin/vinculin-like0.3064Inherited
Notch domain0.39Inherited
Thyroglobulin type-1 domain0.39Inherited
(Trans)glycosidases0.3979Inherited
RING/U-box0.4478Inherited
Spermadhesin, CUB domain0.452Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4752Inherited
Riboflavin synthase domain-like0.4752Inherited
TIMP-like0.4752Inherited
L domain-like0.4969Inherited
Actin-like ATPase domain0.6713Inherited
WW domain0.8734Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Troponin T0Direct
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
L domain0.000005892Direct
Growth factor receptor domain0.00001061Direct
TB module/8-cys domain0.00003476Direct
HLH, helix-loop-helix DNA-binding domain0.0001897Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0002672Direct
NADPH-cytochrome p450 reductase-like0.0002672Direct
Forkhead DNA-binding domain0.001077Inherited
Paired domain0.001363Inherited
SRF-like0.00161Inherited
Homeodomain0.004314Inherited
EGF-type module0.01151Inherited
Plakin repeat0.01189Inherited
ZZ domain0.03285Inherited
B-box zinc-binding domain0.06185Inherited
Small Kunitz-type inhibitors & BPTI-like toxins0.06466Inherited
Transforming growth factor (TGF)-beta0.0735Inherited
Ovomucoid domain III-like0.1183Inherited
Laminin-type module0.1631Inherited
28-residue LRR0.2041Inherited
I set domains0.251Inherited
Notch domain0.3573Inherited
EF-hand modules in multidomain proteins0.3573Inherited
Thyroglobulin type-1 domain0.3573Inherited
Spermadhesin, CUB domain0.4223Inherited
Ngr ectodomain-like0.6302Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.6449Inherited
WW domain0.8571Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
Troponin coil-coiled subunits0Direct
TB module/8-cys domain0.00002233Direct
HLH, helix-loop-helix DNA-binding domain0.00007125Direct
Growth factor receptor domain0.000654Direct
SRF-like0.001253Inherited
Flavoproteins0.002119Inherited
Homeodomain-like0.004081Inherited
Cystine-knot cytokines0.009132Inherited
Plakin repeat0.00954Inherited
B-box zinc-binding domain0.04842Inherited
BPTI-like0.05409Inherited
Kazal-type serine protease inhibitors0.08678Inherited
Clavaminate synthase-like0.1171Inherited
EGF/Laminin0.1985Inherited
"Winged helix" DNA-binding domain0.2029Inherited
Metalloproteases ("zincins"), catalytic domain0.2095Inherited
alpha-catenin/vinculin-like0.2628Inherited
Thyroglobulin type-1 domain0.3436Inherited
Notch domain0.3436Inherited
(Trans)glycosidases0.3513Inherited
RING/U-box0.4002Inherited
Spermadhesin, CUB domain0.4044Inherited
Riboflavin synthase domain-like0.4275Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4275Inherited
TIMP-like0.4275Inherited
L domain-like0.4493Inherited
Actin-like ATPase domain0.629Inherited
Intermediate filament protein, coiled coil region0.629Inherited
WW domain0.8442Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55486,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    49265,56112
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.000003549Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.000003549Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0002751Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.0008172Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0008172Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.001253Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.002387Inherited
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.004299Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.004299Inherited
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.00954Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.1539Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.2416Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.2628Inherited
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.2628Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.3436Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.3436Inherited
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0.3436Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3509Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49854,49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    48726,49265,56112
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,49854,57196
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0Direct
    55486,49854,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.000003549Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00001762Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001937Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001945Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0001945Direct
    90257,90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.0001945Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0008172Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0008172Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.001253Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.004299Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.08916Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1171Inherited
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.2628Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3436Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.4275Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4771Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)