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Mammalian Phenotype (MP): abnormal T cell differentiation

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + + 8:   mammalian phenotype [MP:0000001] <29>
+ + + + + + + 7:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + + 6:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + + + + 5:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
+ + + + + 5:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + + 5:   abnormal blood cell morphology/development [MP:0002429] <3>(26|35) (28|24|9)
+ + + + 4:   abnormal hemopoiesis [MP:0013693] <2>(25|34) (27|24|9)
+ + + + 4:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
+ + + + 4:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + 3:   abnormal mononuclear cell morphology [MP:0008247] <2>(33|57) (41|28|14)
+ + + 3:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
+ + + 3:   abnormal definitive hematopoiesis [MP:0002123] <4>(24|34) (26|24|9)
+ + 2:   abnormal leukopoiesis [MP:0005460] <3>(17|28) (21|18|8)
+ + 2:   abnormal lymphocyte morphology [MP:0002619] <5>(27|46) (33|26|14)
+ 1:   abnormal lymphopoiesis [MP:0002401] <3>(17|25) (21|15|6)
+ 1:   abnormal T cell morphology [MP:0008037] <9>(14|25) (18|19|11)
0:   abnormal T cell differentiation [MP:0002145] <9>(6|9) (10|8|3)
- 1:   abnormal T cell receptor V(D)J recombination [MP:0008754] <4>(0|0) (0|0|0)
- 1:   abnormal CD4-positive T cell differentiation [MP:0008076] <3>(0|3) (2|3|2)
- 1:   abnormal T cell selection [MP:0004917] <2>(2|2) (2|0|0)
- 1:   abnormal double-negative T cell morphology [MP:0002407] <2>(0|0) (2|3|1)
- 1:   abnormal double-positive T cell morphology [MP:0002408] <2>(1|2) (1|3|1)
- 1:   abnormal CD8-positive, alpha-beta T cell differentiation [MP:0008080](1|1) (1|0|0)
- 1:   abnormal T-helper 17 cell differentiation [MP:0010221](0|0) (0|0|0)
- 1:   abnormal gamma-delta T cell differentiation [MP:0008356](0|0) (0|0|0)
- 1:   arrested T cell differentiation [MP:0001825](0|0) (0|1|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53-like transcription factors0.00003044Direct
Bcl-2 inhibitors of programmed cell death0.00004562Direct
E2F-DP heterodimerization region0.000183Direct
Cysteine-rich domain0.1566Inherited
SH3-domain0.4027Inherited
TNF receptor-like0.5809Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Bcl-2 inhibitors of programmed cell death0.00002688Direct
E2F dimerization segment0.00003872Direct
Cell cycle transcription factor e2f-dp0.0004727Direct
STAT DNA-binding domain0.008769Inherited
STAT0.008769Inherited
Transcription factor STAT-4 N-domain0.008769Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.03076Inherited
SH3-domain0.3552Inherited
TNF receptor-like0.3615Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53-like transcription factors0.00001398Direct
Bcl-2 inhibitors of programmed cell death0.00002134Direct
E2F-DP heterodimerization region0.00009208Direct
STAT0.008512Inherited
Transcription factor STAT-4 N-domain0.008512Inherited
beta-beta-alpha zinc fingers0.01969Inherited
Acyl-CoA N-acyltransferases (Nat)0.09251Inherited
Cysteine-rich domain0.1246Inherited
SH3-domain0.3559Inherited
TNF receptor-like0.5346Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000001547Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.00009208Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.008512Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.008512Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.008512Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.04072Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.09897Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.008512Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.008512Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)