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Mammalian Phenotype (MP): abnormal reproductive system morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   reproductive system phenotype [MP:0005389] <2>(37|56) (46|17|6)
0:   abnormal reproductive system morphology [MP:0002160] <12>(27|44) (36|14|6)
- 1:   abnormal reproductive system development [MP:0003936] <10>(0|0) (0|0|0)
- 1:   abnormal gametogenesis [MP:0001929] <7>(14|17) (18|2|1)
- 1:   genital wound [MP:0013055] <6>(0|0) (0|0|0)
- 1:   abnormal sex gland morphology [MP:0000653] <5>(18|27) (23|9|2)
- 1:   increased reproductive system tumor incidence [MP:0010287] <4>(3|4) (3|0|0)
- 1:   abnormal inguinal canal morphology [MP:0003673] <3>(0|0) (0|0|0)
- 1:   abnormal perineum morphology [MP:0003315] <3>(0|0) (0|0|0)
- 1:   abnormal sex determination [MP:0002210] <3>(6|15) (12|5|3)
- 1:   abnormal female reproductive system morphology [MP:0001119] <2>(13|22) (17|8|2)
- 1:   abnormal male reproductive system morphology [MP:0001145] <2>(11|16) (15|3|0)
- 1:   decreased reproductive system tumor incidence [MP:0012417] <2>(0|0) (0|0|0)
- 1:   abnormal gubernaculum morphology [MP:0005149](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
E2F-DP heterodimerization region0.0009159Direct
Cysteine-rich DNA binding domain, (DM domain)0.0009159Direct
PAZ domain0.00245Inherited
The spindle assembly checkpoint protein mad20.00477Inherited
Tudor/PWWP/MBT0.02964Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.106Inherited
HMG-box0.1255Inherited
Nuclear receptor ligand-binding domain0.1328Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1506Inherited
SMAD MH1 domain0.1506Inherited
SMAD/FHA domain0.1735Inherited
Nucleic acid-binding proteins0.1735Inherited
Bcl-2 inhibitors of programmed cell death0.1984Inherited
Protein kinase-like (PK-like)0.2001Inherited
Fibronectin type III0.2586Inherited
Cystine-knot cytokines0.2865Inherited
Transcription factor STAT-4 N-domain0.343Inherited
STAT0.343Inherited
SAICAR synthase-like0.343Inherited
LDL receptor-like module0.3707Inherited
4-helical cytokines0.47Inherited
BAR/IMD domain-like0.6512Inherited
Homeodomain-like0.9351Inherited
L domain-like0.9438Inherited
Immunoglobulin1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 tetramerization domain0Direct
E2F dimerization segment0.0001208Direct
Cysteine-rich DNA binding domain, (DM domain)0.0005666Direct
DNA repair protein MutS, domain III0.0006343Direct
Extracellular domain of cell surface receptors0.0009438Direct
PAZ domain0.001595Inherited
The spindle assembly checkpoint protein mad20.003166Inherited
Cell cycle transcription factor e2f-dp0.003513Inherited
Single strand DNA-binding domain, SSB0.006142Inherited
Nuclear receptor coactivator interlocking domain0.01024Inherited
Transforming growth factor (TGF)-beta0.02502Inherited
Nuclear receptor ligand-binding domain0.09948Inherited
HMG-box0.1059Inherited
SMAD domain0.1188Inherited
SMAD MH1 domain0.1188Inherited
Forkhead DNA-binding domain0.1372Inherited
Nuclear receptor0.1424Inherited
Bcl-2 inhibitors of programmed cell death0.1617Inherited
Insulin-like0.1617Inherited
Protein kinases, catalytic subunit0.1717Inherited
ABC transporter ATPase domain-like0.2143Inherited
Tudor domain0.2143Inherited
L domain0.2194Inherited
Fibronectin type III0.2392Inherited
Growth factor receptor domain0.2881Inherited
Cytochrome p450 reductase N-terminal domain-like0.2978Inherited
STAT0.2978Inherited
Transcription factor STAT-4 N-domain0.2978Inherited
STAT DNA-binding domain0.2978Inherited
Gonadodropin/Follitropin0.2978Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.2978Inherited
NADPH-cytochrome p450 reductase-like0.2978Inherited
LDL receptor-like module0.3215Inherited
Short-chain cytokines0.551Inherited
Histone lysine methyltransferases0.551Inherited
PHD domain0.8032Inherited
Ngr ectodomain-like0.875Inherited
Homeodomain0.941Inherited
I set domains0.9526Inherited
Rhodopsin-like0.9975Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
E2F-DP heterodimerization region0.0004967Direct
Cysteine-rich DNA binding domain, (DM domain)0.0004967Direct
DNA repair protein MutS, domain III0.0005621Direct
PAZ domain0.001405Inherited
The spindle assembly checkpoint protein mad20.002848Inherited
Nuclear receptor coactivator interlocking domain0.009293Inherited
Tudor/PWWP/MBT0.02017Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.08063Inherited
Ribonuclease H-like0.08864Inherited
HMG-box0.09735Inherited
Nuclear receptor ligand-binding domain0.1037Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1192Inherited
SMAD MH1 domain0.1192Inherited
SMAD/FHA domain0.1393Inherited
Nucleic acid-binding proteins0.1393Inherited
Insulin-like0.162Inherited
Bcl-2 inhibitors of programmed cell death0.162Inherited
Protein kinase-like (PK-like)0.1635Inherited
Cytochrome P4500.1733Inherited
Fibronectin type III0.2178Inherited
dsRNA-binding domain-like0.22Inherited
Cystine-knot cytokines0.2441Inherited
SAICAR synthase-like0.2979Inherited
Transcription factor STAT-4 N-domain0.2979Inherited
STAT0.2979Inherited
"Winged helix" DNA-binding domain0.3063Inherited
LDL receptor-like module0.325Inherited
4-helical cytokines0.4224Inherited
Growth factor receptor domain0.4926Inherited
BAR/IMD domain-like0.608Inherited
Homeodomain-like0.9118Inherited
L domain-like0.9217Inherited
Family A G protein-coupled receptor-like0.9841Inherited
Immunoglobulin1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0004967Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0005621Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.009293Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2039Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2039Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2123Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.22Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.22Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2979Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2979Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2979Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9334Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1316Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.22Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2979Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2979Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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