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Mammalian Phenotype (MP): abnormal reproductive system morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   reproductive system phenotype [MP:0005389] <2>(37|56) (46|17|6)
0:   abnormal reproductive system morphology [MP:0002160] <12>(27|44) (36|14|6)
- 1:   abnormal reproductive system development [MP:0003936] <10>(0|0) (0|0|0)
- 1:   abnormal gametogenesis [MP:0001929] <7>(14|17) (18|2|1)
- 1:   genital wound [MP:0013055] <6>(0|0) (0|0|0)
- 1:   abnormal sex gland morphology [MP:0000653] <5>(18|27) (23|9|2)
- 1:   increased reproductive system tumor incidence [MP:0010287] <4>(3|4) (3|0|0)
- 1:   abnormal inguinal canal morphology [MP:0003673] <3>(0|0) (0|0|0)
- 1:   abnormal perineum morphology [MP:0003315] <3>(0|0) (0|0|0)
- 1:   abnormal sex determination [MP:0002210] <3>(6|15) (12|5|3)
- 1:   abnormal female reproductive system morphology [MP:0001119] <2>(13|22) (17|8|2)
- 1:   abnormal male reproductive system morphology [MP:0001145] <2>(11|16) (15|3|0)
- 1:   decreased reproductive system tumor incidence [MP:0012417] <2>(0|0) (0|0|0)
- 1:   abnormal gubernaculum morphology [MP:0005149](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
E2F-DP heterodimerization region0.0009157Direct
Cysteine-rich DNA binding domain, (DM domain)0.0009157Direct
PAZ domain0.002449Inherited
The spindle assembly checkpoint protein mad20.004769Inherited
Tudor/PWWP/MBT0.02963Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.106Inherited
HMG-box0.1255Inherited
Nuclear receptor ligand-binding domain0.1328Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1506Inherited
SMAD MH1 domain0.1506Inherited
Nucleic acid-binding proteins0.1735Inherited
SMAD/FHA domain0.1735Inherited
Bcl-2 inhibitors of programmed cell death0.1984Inherited
Protein kinase-like (PK-like)0.2001Inherited
Fibronectin type III0.2586Inherited
Cystine-knot cytokines0.2865Inherited
Transcription factor STAT-4 N-domain0.343Inherited
SAICAR synthase-like0.343Inherited
STAT0.343Inherited
LDL receptor-like module0.3708Inherited
4-helical cytokines0.47Inherited
BAR/IMD domain-like0.6512Inherited
Homeodomain-like0.9351Inherited
L domain-like0.9438Inherited
Immunoglobulin1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
p53 DNA-binding domain-like0Direct
E2F dimerization segment0.0001204Direct
Cysteine-rich DNA binding domain, (DM domain)0.0005645Direct
DNA repair protein MutS, domain III0.0006321Direct
Extracellular domain of cell surface receptors0.0009412Direct
PAZ domain0.00159Inherited
The spindle assembly checkpoint protein mad20.003159Inherited
Cell cycle transcription factor e2f-dp0.003502Inherited
Single strand DNA-binding domain, SSB0.006124Inherited
Nuclear receptor coactivator interlocking domain0.01022Inherited
Transforming growth factor (TGF)-beta0.02512Inherited
Nuclear receptor ligand-binding domain0.09986Inherited
HMG-box0.1057Inherited
SMAD domain0.1189Inherited
SMAD MH1 domain0.1189Inherited
Forkhead DNA-binding domain0.1375Inherited
Nuclear receptor0.1429Inherited
Insulin-like0.1619Inherited
Bcl-2 inhibitors of programmed cell death0.1619Inherited
Protein kinases, catalytic subunit0.1725Inherited
Tudor domain0.2145Inherited
ABC transporter ATPase domain-like0.2145Inherited
L domain0.2196Inherited
Fibronectin type III0.2381Inherited
Growth factor receptor domain0.2885Inherited
STAT0.298Inherited
NADPH-cytochrome p450 reductase-like0.298Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.298Inherited
STAT DNA-binding domain0.298Inherited
Transcription factor STAT-4 N-domain0.298Inherited
Cytochrome p450 reductase N-terminal domain-like0.298Inherited
Gonadodropin/Follitropin0.298Inherited
LDL receptor-like module0.3218Inherited
Histone lysine methyltransferases0.5514Inherited
Short-chain cytokines0.5514Inherited
PHD domain0.8037Inherited
Ngr ectodomain-like0.8755Inherited
Homeodomain0.9414Inherited
I set domains0.9522Inherited
Rhodopsin-like0.9975Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
E2F-DP heterodimerization region0.0004965Direct
Cysteine-rich DNA binding domain, (DM domain)0.0004965Direct
DNA repair protein MutS, domain III0.0005619Direct
PAZ domain0.001404Inherited
The spindle assembly checkpoint protein mad20.002847Inherited
Nuclear receptor coactivator interlocking domain0.00929Inherited
Tudor/PWWP/MBT0.02017Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.08062Inherited
Ribonuclease H-like0.08864Inherited
HMG-box0.09734Inherited
Nuclear receptor ligand-binding domain0.1036Inherited
SMAD MH1 domain0.1192Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1192Inherited
Nucleic acid-binding proteins0.1393Inherited
SMAD/FHA domain0.1393Inherited
Insulin-like0.162Inherited
Bcl-2 inhibitors of programmed cell death0.162Inherited
Protein kinase-like (PK-like)0.1635Inherited
Cytochrome P4500.1733Inherited
Fibronectin type III0.2178Inherited
dsRNA-binding domain-like0.22Inherited
Cystine-knot cytokines0.2441Inherited
Transcription factor STAT-4 N-domain0.2979Inherited
STAT0.2979Inherited
SAICAR synthase-like0.2979Inherited
"Winged helix" DNA-binding domain0.3063Inherited
LDL receptor-like module0.325Inherited
4-helical cytokines0.4224Inherited
Growth factor receptor domain0.4926Inherited
BAR/IMD domain-like0.6079Inherited
Homeodomain-like0.9118Inherited
L domain-like0.9217Inherited
Family A G protein-coupled receptor-like0.9841Inherited
Immunoglobulin1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0004965Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0005619Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.00929Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2039Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2039Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2123Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.22Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.22Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2979Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2979Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2979Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9334Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1316Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.22Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2979Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2979Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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