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Mammalian Phenotype (MP): abnormal reproductive system morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   reproductive system phenotype [MP:0005389] <2>(37|56) (46|17|6)
0:   abnormal reproductive system morphology [MP:0002160] <12>(27|44) (36|14|6)
- 1:   abnormal reproductive system development [MP:0003936] <10>(0|0) (0|0|0)
- 1:   abnormal gametogenesis [MP:0001929] <7>(14|17) (18|2|1)
- 1:   genital wound [MP:0013055] <6>(0|0) (0|0|0)
- 1:   abnormal sex gland morphology [MP:0000653] <5>(19|27) (23|9|2)
- 1:   increased reproductive system tumor incidence [MP:0010287] <4>(3|4) (3|0|0)
- 1:   abnormal inguinal canal morphology [MP:0003673] <3>(0|0) (0|0|0)
- 1:   abnormal perineum morphology [MP:0003315] <3>(0|0) (0|0|0)
- 1:   abnormal sex determination [MP:0002210] <3>(6|16) (12|5|3)
- 1:   abnormal female reproductive system morphology [MP:0001119] <2>(13|22) (17|8|2)
- 1:   abnormal male reproductive system morphology [MP:0001145] <2>(11|16) (15|3|0)
- 1:   decreased reproductive system tumor incidence [MP:0012417] <2>(0|0) (0|0|0)
- 1:   abnormal gubernaculum morphology [MP:0005149](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Cysteine-rich DNA binding domain, (DM domain)0.0009075Direct
E2F-DP heterodimerization region0.0009075Direct
PAZ domain0.00243Inherited
The spindle assembly checkpoint protein mad20.004746Inherited
Tudor/PWWP/MBT0.02932Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1049Inherited
HMG-box0.125Inherited
Nuclear receptor ligand-binding domain0.1317Inherited
SMAD MH1 domain0.15Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.15Inherited
SMAD/FHA domain0.1727Inherited
Nucleic acid-binding proteins0.1727Inherited
Protein kinase-like (PK-like)0.1969Inherited
Fibronectin type III0.2565Inherited
Bcl-2 inhibitors of programmed cell death0.2602Inherited
Cystine-knot cytokines0.2844Inherited
SAICAR synthase-like0.3423Inherited
Transcription factor STAT-4 N-domain0.3423Inherited
STAT0.3423Inherited
LDL receptor-like module0.3696Inherited
4-helical cytokines0.4685Inherited
BAR/IMD domain-like0.6712Inherited
L domain-like0.9429Inherited
Homeodomain-like0.9542Inherited
Immunoglobulin1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
E2F dimerization segment0.00012Direct
Cysteine-rich DNA binding domain, (DM domain)0.0005624Direct
DNA repair protein MutS, domain III0.0006308Direct
Extracellular domain of cell surface receptors0.0009349Direct
PAZ domain0.001581Inherited
The spindle assembly checkpoint protein mad20.00315Inherited
Cell cycle transcription factor e2f-dp0.00349Inherited
Single strand DNA-binding domain, SSB0.006109Inherited
Nuclear receptor coactivator interlocking domain0.01019Inherited
Transforming growth factor (TGF)-beta0.02469Inherited
Nuclear receptor ligand-binding domain0.09835Inherited
HMG-box0.1055Inherited
SMAD domain0.1182Inherited
SMAD MH1 domain0.1182Inherited
Forkhead DNA-binding domain0.1363Inherited
Nuclear receptor0.1411Inherited
Insulin-like0.1608Inherited
Protein kinases, catalytic subunit0.1682Inherited
Tudor domain0.2129Inherited
ABC transporter ATPase domain-like0.2129Inherited
L domain0.2186Inherited
Bcl-2 inhibitors of programmed cell death0.2186Inherited
Fibronectin type III0.2374Inherited
Growth factor receptor domain0.2863Inherited
STAT0.297Inherited
Gonadodropin/Follitropin0.297Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.297Inherited
Cytochrome p450 reductase N-terminal domain-like0.297Inherited
Transcription factor STAT-4 N-domain0.297Inherited
NADPH-cytochrome p450 reductase-like0.297Inherited
STAT DNA-binding domain0.297Inherited
LDL receptor-like module0.3198Inherited
Histone lysine methyltransferases0.5496Inherited
Short-chain cytokines0.5496Inherited
PHD domain0.8018Inherited
Ngr ectodomain-like0.8738Inherited
I set domains0.9477Inherited
Homeodomain0.9598Inherited
Rhodopsin-like0.9973Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cysteine-rich DNA binding domain, (DM domain)0.0004928Direct
E2F-DP heterodimerization region0.0004928Direct
DNA repair protein MutS, domain III0.0005591Direct
PAZ domain0.001393Inherited
The spindle assembly checkpoint protein mad20.002832Inherited
Nuclear receptor coactivator interlocking domain0.009255Inherited
Tudor/PWWP/MBT0.01991Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07963Inherited
Ribonuclease H-like0.08815Inherited
HMG-box0.09682Inherited
Nuclear receptor ligand-binding domain0.1026Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1187Inherited
SMAD MH1 domain0.1187Inherited
Nucleic acid-binding proteins0.1386Inherited
SMAD/FHA domain0.1386Inherited
Protein kinase-like (PK-like)0.1605Inherited
Insulin-like0.1614Inherited
Cytochrome P4500.1725Inherited
Fibronectin type III0.2158Inherited
Bcl-2 inhibitors of programmed cell death0.2192Inherited
dsRNA-binding domain-like0.2192Inherited
Cystine-knot cytokines0.2421Inherited
SAICAR synthase-like0.2971Inherited
Transcription factor STAT-4 N-domain0.2971Inherited
STAT0.2971Inherited
"Winged helix" DNA-binding domain0.3038Inherited
LDL receptor-like module0.3237Inherited
4-helical cytokines0.4207Inherited
Growth factor receptor domain0.4904Inherited
BAR/IMD domain-like0.629Inherited
L domain-like0.9207Inherited
Homeodomain-like0.9332Inherited
Family A G protein-coupled receptor-like0.9837Inherited
Immunoglobulin1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0004928Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0005591Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.009255Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2026Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2026Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2112Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.2192Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.2192Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2971Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2971Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2971Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9326Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1305Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.2192Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2971Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2971Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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