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Mammalian Phenotype (MP): abnormal gland morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   endocrine/exocrine gland phenotype [MP:0005379] <2>(50|79) (55|35|12)
0:   abnormal gland morphology [MP:0002163] <8>(43|69) (50|30|11)
- 1:   abnormal pancreas morphology [MP:0001944] <17>(7|12) (8|7|4)
- 1:   increased gland tumor incidence [MP:0010288] <15>(6|9) (7|2|0)
- 1:   abnormal exocrine gland morphology [MP:0013558] <13>(18|22) (19|13|8)
- 1:   abnormal bile duct morphology [MP:0002928] <10>(1|1) (1|0|0)
- 1:   abnormal endocrine gland morphology [MP:0013560] <7>(16|29) (21|19|4)
- 1:   abnormal gallbladder morphology [MP:0005084] <6>(0|0) (0|0|0)
- 1:   decreased gland tumor incidence [MP:0012416] <6>(0|0) (0|0|0)
- 1:   abnormal sex gland morphology [MP:0000653] <5>(19|27) (23|9|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog/intein (Hint) domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
p53 tetramerization domain0Direct
Hedgehog/DD-peptidase0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain-like0.0000000003772Direct
Nuclear receptor ligand-binding domain0.000000615Direct
p53-like transcription factors0.000009446Direct
Insulin-like0.00005619Direct
SH2 domain0.0001488Direct
SMAD MH1 domain0.0001958Direct
E2F-DP heterodimerization region0.0006647Direct
Transcription factor STAT-4 N-domain0.0006647Direct
STAT0.0006647Direct
HLH, helix-loop-helix DNA-binding domain0.001099Inherited
PAZ domain0.002856Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.002917Inherited
4-helical cytokines0.002945Inherited
HMG-box0.004103Inherited
Notch domain0.006676Inherited
The spindle assembly checkpoint protein mad20.01991Inherited
beta-beta-alpha zinc fingers0.1155Inherited
Band 7/SPFH domain0.1518Inherited
CCCH zinc finger0.2535Inherited
BRCT domain0.2748Inherited
Cystine-knot cytokines0.2907Inherited
E set domains0.3056Inherited
Rhodanese/Cell cycle control phosphatase0.3264Inherited
RING/U-box0.3493Inherited
WW domain0.3564Inherited
Tudor/PWWP/MBT0.3712Inherited
EGF/Laminin0.381Inherited
Cysteine-rich domain0.5216Inherited
SMAD/FHA domain0.5741Inherited
LDL receptor-like module0.6026Inherited
TNF receptor-like0.6632Inherited
Bcl-2 inhibitors of programmed cell death0.7302Inherited
Intermediate filament protein, coiled coil region0.8037Inherited
Nucleic acid-binding proteins0.8161Inherited
TNF-like0.8963Inherited
Immunoglobulin0.9931Inherited
Family A G protein-coupled receptor-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Retinoblastoma tumor suppressor domains0Direct
Pointed domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog (development protein), N-terminal signaling domain0Direct
RUNT domain0Direct
p53 DNA-binding domain-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
p53 tetramerization domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
E2F dimerization segment0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Homeodomain0.000000008373Direct
Nuclear receptor ligand-binding domain0.000000672Direct
Nuclear receptor0.000004031Direct
Insulin-like0.00003896Direct
Paired domain0.00003896Direct
SMAD domain0.0001373Direct
SMAD MH1 domain0.0001373Direct
SH2 domain0.000185Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0002329Direct
STAT0.0004728Direct
L domain0.0004728Direct
CUT domain0.0004728Direct
Transcription factor STAT-4 N-domain0.0004728Direct
STAT DNA-binding domain0.0004728Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0007644Direct
Growth factor receptor domain0.0009565Direct
HLH, helix-loop-helix DNA-binding domain0.001299Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.001766Inherited
Transforming growth factor (TGF)-beta0.001901Inherited
PAZ domain0.002157Inherited
HMG-box0.003849Inherited
Short-chain cytokines0.00439Inherited
ets domain0.004694Inherited
Tudor domain0.004964Inherited
Notch domain0.00501Inherited
Cell cycle transcription factor e2f-dp0.005993Inherited
Forkhead DNA-binding domain0.009195Inherited
Extracellular domain of cell surface receptors0.01281Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.01528Inherited
The spindle assembly checkpoint protein mad20.01545Inherited
DNA polymerase I0.01699Inherited
Single strand DNA-binding domain, SSB0.03692Inherited
Cysteine-rich DNA binding domain, (DM domain)0.03692Inherited
Transducin (alpha subunit), insertion domain0.04264Inherited
Gonadodropin/Follitropin0.04421Inherited
Long-chain cytokines0.07983Inherited
Linker histone H1/H50.1009Inherited
DnaQ-like 3'-5' exonuclease0.1064Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1201Inherited
CCCH zinc finger0.2372Inherited
WW domain0.3535Inherited
Phosphotyrosine-binding domain (PTB)0.3654Inherited
Cell cycle control phosphatase, catalytic domain0.3763Inherited
EGF-type module0.5304Inherited
LDL receptor-like module0.5596Inherited
TNF receptor-like0.6243Inherited
Cytochrome P4500.6929Inherited
Bcl-2 inhibitors of programmed cell death0.6938Inherited
Papain-like0.7723Inherited
FHA domain0.7723Inherited
Intermediate filament protein, coiled coil region0.8075Inherited
DEATH domain, DD0.8288Inherited
TNF-like0.8727Inherited
I set domains0.9975Inherited
Rhodopsin-like1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Hedgehog/intein (Hint) domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog/DD-peptidase0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Homeodomain-like0.0000000001387Direct
Nuclear receptor ligand-binding domain0.0000002478Direct
p53-like transcription factors0.000004125Direct
Insulin-like0.00002639Direct
SH2 domain0.00007417Direct
SMAD MH1 domain0.00009866Direct
E2F-DP heterodimerization region0.0003553Direct
Transcription factor STAT-4 N-domain0.0003553Direct
STAT0.0003553Direct
HLH, helix-loop-helix DNA-binding domain0.0006032Direct
PAZ domain0.001655Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.001691Inherited
4-helical cytokines0.001706Inherited
HMG-box0.002423Inherited
Ribonuclease H-like0.002741Inherited
Notch domain0.004076Inherited
The spindle assembly checkpoint protein mad20.01306Inherited
Cysteine-rich DNA binding domain, (DM domain)0.03139Inherited
Transducin (alpha subunit), insertion domain0.03456Inherited
beta-beta-alpha zinc fingers0.0888Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.09099Inherited
Band 7/SPFH domain0.1203Inherited
"Winged helix" DNA-binding domain0.1439Inherited
CCCH zinc finger0.2129Inherited
BRCT domain0.2331Inherited
Cystine-knot cytokines0.248Inherited
E set domains0.2621Inherited
Rhodanese/Cell cycle control phosphatase0.282Inherited
RING/U-box0.3041Inherited
WW domain0.3109Inherited
Tudor/PWWP/MBT0.3253Inherited
EGF/Laminin0.3349Inherited
Cysteine-rich domain0.4742Inherited
SMAD/FHA domain0.5277Inherited
LDL receptor-like module0.5571Inherited
TNF receptor-like0.6207Inherited
Cytochrome P4500.6459Inherited
Bcl-2 inhibitors of programmed cell death0.6912Inherited
Intermediate filament protein, coiled coil region0.7691Inherited
Nucleic acid-binding proteins0.7824Inherited
Protein kinase-like (PK-like)0.8208Inherited
TNF-like0.869Inherited
Immunoglobulin0.9786Inherited
Family A G protein-coupled receptor-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00006519Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0001649Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0003553Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0003553Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0003553Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0003553Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0003553Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0003553Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.001655Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.002008Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01081Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.01306Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.023Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0246Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0246Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02688Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03092Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.03842Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.07232Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.07488Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.07488Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.2331Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2389Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.5451Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.819Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9833Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0003553Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0003553Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0003553Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003277Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01236Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01416Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.04985Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.07133Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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