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Mammalian Phenotype (MP): altered tumor susceptibility

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
0:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
- 1:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
- 1:   abnormal tumor latency [MP:0010307] <2>(0|0) (0|0|0)
- 1:   preneoplasia [MP:0002009](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.00002219Direct
DNA/RNA polymerases0.00008258Direct
SMAD/FHA domain0.0008531Direct
Bcl-2 inhibitors of programmed cell death0.0009878Direct
Cyclin-like0.001435Inherited
DNA-glycosylase0.00148Inherited
Restriction endonuclease-like0.00148Inherited
SPOC domain-like0.00148Inherited
Nucleic acid-binding proteins0.001837Inherited
DNA repair protein MutS, domain III0.004853Inherited
Notch domain0.004853Inherited
SAND domain-like0.004853Inherited
Putative DNA-binding domain0.01815Inherited
BRCT domain0.02944Inherited
Protein kinase-like (PK-like)0.05625Inherited
CCCH zinc finger0.08821Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1214Inherited
SET domain0.1485Inherited
RING/U-box0.1806Inherited
ARM repeat0.2459Inherited
Ubiquitin-like0.3918Inherited
Intermediate filament protein, coiled coil region0.4912Inherited
p53-like transcription factors0.5517Inherited
4-helical cytokines0.9355Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
SMAD domain0.00001647Direct
SMAD MH1 domain0.00001647Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.00001647Direct
DNA polymerase I0.0006667Direct
Bcl-2 inhibitors of programmed cell death0.0007637Direct
XPF/Rad1/Mus81 nuclease0.001079Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001109Inherited
Pointed domain0.001739Inherited
L domain0.001739Inherited
Notch domain0.003749Inherited
DNA repair protein MutS, domain III0.003749Inherited
p120GAP domain-like0.01023Inherited
Forkhead DNA-binding domain0.01326Inherited
Pyrin domain, PYD0.01494Inherited
Single strand DNA-binding domain, SSB0.01494Inherited
DnaQ-like 3'-5' exonuclease0.02137Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.029Inherited
Histone lysine methyltransferases0.05264Inherited
Protein kinases, catalytic subunit0.0591Inherited
CCCH zinc finger0.07876Inherited
FHA domain0.1316Inherited
Phosphotyrosine-binding domain (PTB)0.4563Inherited
Intermediate filament protein, coiled coil region0.4976Inherited
ABC transporter ATPase domain-like0.5128Inherited
Short-chain cytokines0.716Inherited
Interferons/interleukin-10 (IL-10)0.7673Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.00001001Direct
DNA/RNA polymerases0.00003955Direct
SMAD/FHA domain0.0004616Direct
Bcl-2 inhibitors of programmed cell death0.0005384Direct
Cyclin-like0.0008017Direct
Restriction endonuclease-like0.0008286Direct
SPOC domain-like0.0008286Direct
DNA-glycosylase0.0008286Direct
Nucleic acid-binding proteins0.00104Inherited
DNA repair protein MutS, domain III0.002904Inherited
Notch domain0.002904Inherited
SAND domain-like0.002904Inherited
Chromo domain-like0.005804Inherited
Snake toxin-like0.008437Inherited
Putative DNA-binding domain0.01184Inherited
BRCT domain0.02001Inherited
Cysteine-rich domain0.02609Inherited
Protein kinase-like (PK-like)0.0402Inherited
Ribonuclease H-like0.04772Inherited
CCCH zinc finger0.0658Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.09372Inherited
SET domain0.1173Inherited
RING/U-box0.1457Inherited
ARM repeat0.2061Inherited
Ubiquitin-like0.3454Inherited
Intermediate filament protein, coiled coil region0.4434Inherited
p53-like transcription factors0.5049Inherited
Leucine zipper domain0.5406Inherited
4-helical cytokines0.9123Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0008286Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0008322Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001279Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001279Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.002677Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002904Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.02273Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.04754Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.14Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.7645Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0008286Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001279Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.08119Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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