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Mammalian Phenotype (MP): altered tumor susceptibility

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
0:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
- 1:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
- 1:   abnormal tumor latency [MP:0010307] <2>(0|0) (0|0|0)
- 1:   preneoplasia [MP:0002009](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.0000221Direct
DNA/RNA polymerases0.00008221Direct
SMAD/FHA domain0.0008494Direct
Bcl-2 inhibitors of programmed cell death0.0009848Direct
Cyclin-like0.001429Inherited
Restriction endonuclease-like0.001477Inherited
SPOC domain-like0.001477Inherited
DNA-glycosylase0.001477Inherited
Nucleic acid-binding proteins0.001829Inherited
SAND domain-like0.004847Inherited
DNA repair protein MutS, domain III0.004847Inherited
Notch domain0.004847Inherited
Putative DNA-binding domain0.01814Inherited
BRCT domain0.02941Inherited
Protein kinase-like (PK-like)0.05624Inherited
CCCH zinc finger0.08809Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1212Inherited
SET domain0.1482Inherited
RING/U-box0.1806Inherited
ARM repeat0.2461Inherited
Ubiquitin-like0.3914Inherited
Intermediate filament protein, coiled coil region0.4908Inherited
p53-like transcription factors0.5518Inherited
4-helical cytokines0.9355Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
SMAD MH1 domain0.00001641Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.00001641Direct
SMAD domain0.00001641Direct
DNA polymerase I0.0006617Direct
Bcl-2 inhibitors of programmed cell death0.0007581Direct
XPF/Rad1/Mus81 nuclease0.001071Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0011Inherited
Pointed domain0.001728Inherited
L domain0.001728Inherited
Notch domain0.003729Inherited
DNA repair protein MutS, domain III0.003729Inherited
p120GAP domain-like0.01018Inherited
Forkhead DNA-binding domain0.01319Inherited
Single strand DNA-binding domain, SSB0.01488Inherited
Pyrin domain, PYD0.01488Inherited
DnaQ-like 3'-5' exonuclease0.02129Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.02887Inherited
Histone lysine methyltransferases0.05248Inherited
Protein kinases, catalytic subunit0.05898Inherited
CCCH zinc finger0.07858Inherited
FHA domain0.1314Inherited
Phosphotyrosine-binding domain (PTB)0.4762Inherited
Intermediate filament protein, coiled coil region0.4969Inherited
ABC transporter ATPase domain-like0.5121Inherited
Short-chain cytokines0.716Inherited
Interferons/interleukin-10 (IL-10)0.7673Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000009985Direct
DNA/RNA polymerases0.00003943Direct
SMAD/FHA domain0.0004599Direct
Bcl-2 inhibitors of programmed cell death0.0005372Direct
Cyclin-like0.0007991Direct
SPOC domain-like0.0008267Direct
Restriction endonuclease-like0.0008267Direct
DNA-glycosylase0.0008267Direct
Nucleic acid-binding proteins0.001035Inherited
SAND domain-like0.002898Inherited
Notch domain0.002898Inherited
DNA repair protein MutS, domain III0.002898Inherited
Chromo domain-like0.00579Inherited
Snake toxin-like0.008417Inherited
Putative DNA-binding domain0.01183Inherited
BRCT domain0.01997Inherited
Cysteine-rich domain0.02603Inherited
Protein kinase-like (PK-like)0.04019Inherited
Ribonuclease H-like0.04764Inherited
CCCH zinc finger0.0657Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.09353Inherited
SET domain0.1171Inherited
RING/U-box0.1458Inherited
ARM repeat0.2061Inherited
Ubiquitin-like0.345Inherited
Intermediate filament protein, coiled coil region0.4431Inherited
p53-like transcription factors0.505Inherited
Leucine zipper domain0.5405Inherited
4-helical cytokines0.9123Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0008267Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0008297Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001276Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001276Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.002671Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002898Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.02268Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.04747Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1399Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.7645Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0008267Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001276Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0811Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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