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Mammalian Phenotype (MP): abnormal hematopoietic system morphology/development

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
0:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(59|86) (66|47|21)
- 1:   abnormal spleen morphology [MP:0000689] <16>(10|13) (11|8|8)
- 1:   abnormal thymus morphology [MP:0000703] <14>(10|16) (12|10|2)
- 1:   abnormal hematopoietic cell morphology [MP:0013656] <9>(50|77) (60|43|18)
- 1:   abnormal bone marrow cell morphology/development [MP:0002398] <8>(4|8) (6|6|0)
- 1:   abnormal blood cell morphology/development [MP:0002429] <3>(26|35) (28|24|9)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Transcription factor STAT-4 N-domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
PsbU/PolX domain-like0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
BAG domain0Direct
STAT0Direct
ARID-like0.001997Inherited
Integrin domains0.00292Inherited
Nuclear receptor ligand-binding domain0.003154Inherited
Integrin beta tail domain0.004126Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.009025Inherited
L30e-like0.01528Inherited
DNA polymerase beta, N-terminal domain-like0.02268Inherited
Notch domain0.02268Inherited
Flavoproteins0.0318Inherited
SH2 domain0.04787Inherited
Triple coiled coil domain of C-type lectins0.0512Inherited
AraD/HMP-PK domain-like0.0512Inherited
Terpenoid cyclases/Protein prenyltransferases0.06572Inherited
Integrin alpha N-terminal domain0.1123Inherited
p53-like transcription factors0.1185Inherited
E2F-DP heterodimerization region0.1214Inherited
WWE domain0.1214Inherited
CCCH zinc finger0.1512Inherited
Nucleic acid-binding proteins0.2209Inherited
TIMP-like0.2223Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2297Inherited
TNF receptor-like0.2311Inherited
4-helical cytokines0.2607Inherited
Cyclin-like0.3255Inherited
Protein kinase-like (PK-like)0.3363Inherited
BRCT domain0.3495Inherited
E set domains0.3876Inherited
SMAD/FHA domain0.3925Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4181Inherited
Riboflavin synthase domain-like0.4181Inherited
Nucleotidyltransferase0.4341Inherited
PH domain-like0.4443Inherited
Ankyrin repeat0.4781Inherited
Ran binding protein zinc finger-like0.4872Inherited
A DNA-binding domain in eukaryotic transcription factors0.4872Inherited
DBL homology domain (DH-domain)0.5142Inherited
BAR/IMD domain-like0.6658Inherited
Interleukin 8-like chemokines0.677Inherited
SET domain0.7579Inherited
Cysteine-rich domain0.7701Inherited
Calponin-homology domain, CH-domain0.8114Inherited
DNA/RNA polymerases0.8159Inherited
Bcl-2 inhibitors of programmed cell death0.8507Inherited
MHC antigen-recognition domain0.8938Inherited
DEATH domain0.9437Inherited
TNF-like0.956Inherited
Homeodomain-like0.9806Inherited
Immunoglobulin0.9894Inherited
Toll/Interleukin receptor TIR domain1Inherited
SH3-domain1Inherited
Caspase-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Clathrin adaptor appendage, alpha and beta chain-specific domain0Direct
5' to 3' exonuclease catalytic domain0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
beta-glycanases0Direct
Alpha-adaptin ear subdomain-like0Direct
STAT0Direct
Interleukin 17F, IL-17F0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Proteasome subunits0Direct
STAT DNA-binding domain0Direct
Transcription factor STAT-4 N-domain0Direct
DNA polymerase beta-like0Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
BAFF receptor-like0Direct
DNA polymerase beta-like, second domain0Direct
BAG domain0Direct
Pyrin domain, PYD0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0001552Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.000599Direct
Nuclear receptor0.001045Inherited
ARID domain0.001363Inherited
Integrin domains0.002092Inherited
Nuclear receptor ligand-binding domain0.002383Inherited
Integrin beta tail domain0.002811Inherited
Interferons/interleukin-10 (IL-10)0.005008Inherited
DNA polymerase I0.006957Inherited
Integrin beta EGF-like domains0.01119Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.01119Inherited
Notch domain0.0167Inherited
DNA polymerase beta, N-terminal domain-like0.0167Inherited
ets domain0.01945Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.02408Inherited
Pointed domain0.02408Inherited
C2 set domains0.02717Inherited
SH2 domain0.03236Inherited
SWIRM domain0.0392Inherited
AraD-like aldolase/epimerase0.0392Inherited
Tissue inhibitor of metalloproteinases, TIMP0.0392Inherited
Cytochrome p450 reductase N-terminal domain-like0.0392Inherited
Triple coiled coil domain of C-type lectins0.0392Inherited
E2F dimerization segment0.0507Inherited
Noncollagenous (NC1) domain of collagen IV0.0507Inherited
WWE domain0.0507Inherited
Erythroid transcription factor GATA-10.05345Inherited
NADPH-cytochrome p450 reductase-like0.1028Inherited
Nuclear receptor coactivator interlocking domain0.1028Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.1028Inherited
CCCH zinc finger0.1293Inherited
PLC-like (P variant)0.1593Inherited
Eps15 homology domain (EH domain)0.1821Inherited
Cyclin0.2257Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.2338Inherited
Linker histone H1/H50.2339Inherited
Cell cycle transcription factor e2f-dp0.2339Inherited
TNF receptor-like0.2526Inherited
Short-chain cytokines0.304Inherited
Pleckstrin-homology domain (PH domain)0.3295Inherited
Myb/SANT domain0.3658Inherited
C1 set domains (antibody constant domain-like)0.4083Inherited
Ran binding protein zinc finger-like0.4401Inherited
Long-chain cytokines0.4401Inherited
A DNA-binding domain in eukaryotic transcription factors0.4401Inherited
Ankyrin repeat0.4487Inherited
DBL homology domain (DH-domain)0.465Inherited
DEATH domain, DD0.4965Inherited
MATH domain0.5294Inherited
Interferon regulatory factor0.5805Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.5805Inherited
Interleukin 8-like chemokines0.6319Inherited
Interleukin-1 (IL-1)0.6371Inherited
FHA domain0.6464Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.6611Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.6892Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.6983Inherited
Tetraspanin0.6983Inherited
Calponin-homology domain, CH-domain0.7748Inherited
Bcl-2 inhibitors of programmed cell death0.82Inherited
MHC antigen-recognition domain0.867Inherited
V set domains (antibody variable domain-like)0.868Inherited
TNF-like0.9375Inherited
SH3-domain0.999Inherited
Toll/Interleukin receptor TIR domain1Inherited
Homeodomain1Inherited
Caspase recruitment domain, CARD1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
5' to 3' exonuclease, C-terminal subdomain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
BAG domain0Direct
STAT0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
ARID-like0.001135Inherited
Integrin domains0.001691Inherited
Nuclear receptor ligand-binding domain0.001834Inherited
Integrin beta tail domain0.002437Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.005599Inherited
L30e-like0.009841Inherited
DNA polymerase beta, N-terminal domain-like0.01506Inherited
Notch domain0.01506Inherited
Flavoproteins0.02176Inherited
SH2 domain0.03375Inherited
Triple coiled coil domain of C-type lectins0.03623Inherited
AraD/HMP-PK domain-like0.03623Inherited
Terpenoid cyclases/Protein prenyltransferases0.04783Inherited
NAD kinase/diacylglycerol kinase-like0.0796Inherited
beta-beta-alpha zinc fingers0.08109Inherited
Integrin alpha N-terminal domain0.08609Inherited
p53-like transcription factors0.09133Inherited
E2F-DP heterodimerization region0.09375Inherited
WWE domain0.09375Inherited
Nuclear receptor coactivator interlocking domain0.09616Inherited
(Trans)glycosidases0.0968Inherited
CCCH zinc finger0.1199Inherited
Nucleic acid-binding proteins0.1827Inherited
TIMP-like0.184Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1909Inherited
TNF receptor-like0.1923Inherited
4-helical cytokines0.2197Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2559Inherited
Cyclin-like0.2813Inherited
Protein kinase-like (PK-like)0.2913Inherited
BRCT domain0.3043Inherited
E set domains0.3412Inherited
SMAD/FHA domain0.346Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3712Inherited
Riboflavin synthase domain-like0.3712Inherited
Nucleotidyltransferase0.3871Inherited
PH domain-like0.3968Inherited
Ankyrin repeat0.4304Inherited
Ran binding protein zinc finger-like0.4397Inherited
A DNA-binding domain in eukaryotic transcription factors0.4397Inherited
DBL homology domain (DH-domain)0.4668Inherited
BAR/IMD domain-like0.6234Inherited
Interleukin 8-like chemokines0.6351Inherited
SET domain0.7201Inherited
Cysteine-rich domain0.7329Inherited
Calponin-homology domain, CH-domain0.7771Inherited
DNA/RNA polymerases0.7821Inherited
Acyl-CoA N-acyltransferases (Nat)0.7972Inherited
Bcl-2 inhibitors of programmed cell death0.8195Inherited
C-type lectin-like0.8563Inherited
MHC antigen-recognition domain0.8663Inherited
DEATH domain0.9215Inherited
TNF-like0.9353Inherited
Homeodomain-like0.9637Inherited
Immunoglobulin0.9741Inherited
SH3-domain0.9928Inherited
Caspase-like1Inherited
Toll/Interleukin receptor TIR domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
  • 0Direct
    88723,47807
  • 88723 - PIN domain-like
  • 47807 - 5' to 3' exonuclease, C-terminal subdomain
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.000003369Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000006481Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.001444Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.002437Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.002437Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.004327Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.006163Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.006163Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02151Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.02176Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.02457Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.02457Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.03446Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.03446Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.03623Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.03623Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.04665Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.04884Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.09331Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.09375Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1277Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1537Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.1722Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2218Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3174Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.3336Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.3464Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.482Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.482Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.5284Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.5291Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.697Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8674Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.9346Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00005133Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.002437Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.02176Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02458Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.03446Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.04884Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1534Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3336Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.482Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.5768Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.636Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.697Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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